Trichomoniasis
(2024) p.149-179- Abstract
Trichomoniasis is a sexually transmitted infection (STI) caused by the microphilic parasitic protist Trichomonas vaginalis. The common sign and symptoms of the infection are vaginitis, cervicitis, dysuria, urethritis, vaginal discharge with foul smell, pelvic inflammatory disease (PID), dyspareunia, preterm delivery, and low birth weight. It plays a vital role in the transmission and acquisition of HIV. The diagnosis of trophozoites through wet mount microscopy is relatively less sensitive. Culture is the gold standard technique; DNA amplification techniques have higher sensitivity. Metronidazole or tinidazole is the standard therapy with a 95% success rate. Other countries than United States, tinidazole, ornidazole, secnidazole, and... (More)
Trichomoniasis is a sexually transmitted infection (STI) caused by the microphilic parasitic protist Trichomonas vaginalis. The common sign and symptoms of the infection are vaginitis, cervicitis, dysuria, urethritis, vaginal discharge with foul smell, pelvic inflammatory disease (PID), dyspareunia, preterm delivery, and low birth weight. It plays a vital role in the transmission and acquisition of HIV. The diagnosis of trophozoites through wet mount microscopy is relatively less sensitive. Culture is the gold standard technique; DNA amplification techniques have higher sensitivity. Metronidazole or tinidazole is the standard therapy with a 95% success rate. Other countries than United States, tinidazole, ornidazole, secnidazole, and nimorazole, carnidazole with similar effectivity as metronidazole are in use. Metronidazole resistance is an emerging problem. Developing a Trichomonas vaccine is a better option as it would be easily administered, low costing prophylactic means to control Trichomonas globally. Setting new therapeutic targets and molecules to treat Trichomonas infection is urgently demanded worldwide.
(Less)
- author
- Yadav, Sonal ; Kaur, Harpreet ; Dhanda, Rakesh Singh and Yadav, Manisha LU
- organization
- publishing date
- 2024-01-01
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Metronidazole, Trichomonas vaginalis, Trichomoniasis
- host publication
- The Diagnosis and Treatment of Protozoan Diseases
- pages
- 31 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85203316875
- ISBN
- 9780443191619
- 9780443152450
- DOI
- 10.1016/B978-0-443-19161-9.00005-X
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2024 by Elsevier Inc. All rights reserved.
- id
- 50c10464-a7b6-4735-bbc8-193c93727f4d
- date added to LUP
- 2024-12-10 09:36:54
- date last changed
- 2025-07-09 02:36:36
@inbook{50c10464-a7b6-4735-bbc8-193c93727f4d,
abstract = {{<p>Trichomoniasis is a sexually transmitted infection (STI) caused by the microphilic parasitic protist Trichomonas vaginalis. The common sign and symptoms of the infection are vaginitis, cervicitis, dysuria, urethritis, vaginal discharge with foul smell, pelvic inflammatory disease (PID), dyspareunia, preterm delivery, and low birth weight. It plays a vital role in the transmission and acquisition of HIV. The diagnosis of trophozoites through wet mount microscopy is relatively less sensitive. Culture is the gold standard technique; DNA amplification techniques have higher sensitivity. Metronidazole or tinidazole is the standard therapy with a 95% success rate. Other countries than United States, tinidazole, ornidazole, secnidazole, and nimorazole, carnidazole with similar effectivity as metronidazole are in use. Metronidazole resistance is an emerging problem. Developing a Trichomonas vaccine is a better option as it would be easily administered, low costing prophylactic means to control Trichomonas globally. Setting new therapeutic targets and molecules to treat Trichomonas infection is urgently demanded worldwide.</p>}},
author = {{Yadav, Sonal and Kaur, Harpreet and Dhanda, Rakesh Singh and Yadav, Manisha}},
booktitle = {{The Diagnosis and Treatment of Protozoan Diseases}},
isbn = {{9780443191619}},
keywords = {{Metronidazole; Trichomonas vaginalis; Trichomoniasis}},
language = {{eng}},
month = {{01}},
pages = {{149--179}},
publisher = {{Elsevier}},
title = {{Trichomoniasis}},
url = {{http://dx.doi.org/10.1016/B978-0-443-19161-9.00005-X}},
doi = {{10.1016/B978-0-443-19161-9.00005-X}},
year = {{2024}},
}