Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Circulating mitochondrial long non-coding 7S RNA in primary health care patients with depression/anxiety

Wang, Xiao LU ; Memon, Ashfaque A LU orcid ; Hedelius, Anna LU ; Grundberg, Anton LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2024) In Journal of Affective Disorders 349. p.101-106
Abstract

BACKGROUND: The significant role of long non-coding 7S RNA in controlling mitochondrial transcription highlights its importance in mitochondrial function. Considering the suggested connection between mitochondrial dysfunction and the onset of mental disorders, this study aimed to explore the potential involvement of 7S RNA in the context of depression/anxiety.

RESULTS: A total of 181 patients in primary health care (age 20-64 years) with depression/anxiety and 59 healthy controls were included in the study. 7S RNA was measured using quantitative real-time PCR in plasma samples collected before (baseline) and after 8 weeks of treatment (mindfulness or cognitive-based behavioral therapy). Upon adjustment for age and sex, the... (More)

BACKGROUND: The significant role of long non-coding 7S RNA in controlling mitochondrial transcription highlights its importance in mitochondrial function. Considering the suggested connection between mitochondrial dysfunction and the onset of mental disorders, this study aimed to explore the potential involvement of 7S RNA in the context of depression/anxiety.

RESULTS: A total of 181 patients in primary health care (age 20-64 years) with depression/anxiety and 59 healthy controls were included in the study. 7S RNA was measured using quantitative real-time PCR in plasma samples collected before (baseline) and after 8 weeks of treatment (mindfulness or cognitive-based behavioral therapy). Upon adjustment for age and sex, the baseline plasma levels of 7S RNA were significantly higher in patients than in healthy controls (p < 0.001). Notably, post-treatment, there was a significant reduction in 7S RNA levels (p = 0.03). These changes in 7S RNA were related to the treatment response, as indicated by HADS-D (Hospital Anxiety and Depression Scale) scores (ß = -0.04, p = 0.04), even after accounting for baseline scores and other cofounders.

CONCLUSION: The findings of this study indicate an association between plasma 7S RNA levels and depression/anxiety, as well as treatment response. While further confirmatory analyses are necessary, plasma 7S RNA holds promise as a potential predictive biomarker for both depression/anxiety and the treatment response within these disorders.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Affective Disorders
volume
349
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:85182004934
  • pmid:38163568
ISSN
0165-0327
DOI
10.1016/j.jad.2023.12.053
language
English
LU publication?
yes
additional info
Copyright © 2023. Published by Elsevier B.V.
id
50d44d41-8faa-4e05-ad17-8c28e618a195
date added to LUP
2024-01-09 14:57:56
date last changed
2024-04-17 08:18:07
@article{50d44d41-8faa-4e05-ad17-8c28e618a195,
  abstract     = {{<p>BACKGROUND: The significant role of long non-coding 7S RNA in controlling mitochondrial transcription highlights its importance in mitochondrial function. Considering the suggested connection between mitochondrial dysfunction and the onset of mental disorders, this study aimed to explore the potential involvement of 7S RNA in the context of depression/anxiety.</p><p>RESULTS: A total of 181 patients in primary health care (age 20-64 years) with depression/anxiety and 59 healthy controls were included in the study. 7S RNA was measured using quantitative real-time PCR in plasma samples collected before (baseline) and after 8 weeks of treatment (mindfulness or cognitive-based behavioral therapy). Upon adjustment for age and sex, the baseline plasma levels of 7S RNA were significantly higher in patients than in healthy controls (p &lt; 0.001). Notably, post-treatment, there was a significant reduction in 7S RNA levels (p = 0.03). These changes in 7S RNA were related to the treatment response, as indicated by HADS-D (Hospital Anxiety and Depression Scale) scores (ß = -0.04, p = 0.04), even after accounting for baseline scores and other cofounders.</p><p>CONCLUSION: The findings of this study indicate an association between plasma 7S RNA levels and depression/anxiety, as well as treatment response. While further confirmatory analyses are necessary, plasma 7S RNA holds promise as a potential predictive biomarker for both depression/anxiety and the treatment response within these disorders.</p>}},
  author       = {{Wang, Xiao and Memon, Ashfaque A and Hedelius, Anna and Grundberg, Anton and Sundquist, Jan and Sundquist, Kristina}},
  issn         = {{0165-0327}},
  language     = {{eng}},
  month        = {{03}},
  pages        = {{101--106}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Affective Disorders}},
  title        = {{Circulating mitochondrial long non-coding 7S RNA in primary health care patients with depression/anxiety}},
  url          = {{http://dx.doi.org/10.1016/j.jad.2023.12.053}},
  doi          = {{10.1016/j.jad.2023.12.053}},
  volume       = {{349}},
  year         = {{2024}},
}