Advanced

Pankreascancer kan metastasera tidigt : Tumörbiologi tycks viktigare än tumörstorlek

Andersson, Roland LU (2017) In Lakartidningen 114(14).
Abstract

Pancreatic cancers are associated with poor survival and only some 10 per cent are resectable, but even in this subgroup recurrence is very frequent. The traditional view of sequential development of pancreatic cancer has been challenged by novel molecular biological findings, where the tumor quite rapidly might turn metastatic. In about 60 000 patients with diagnosed pancreatic cancer the association between tumor size, metastatic spread and survival was analyzed. Even the smallest tumors (<0.5 cm) had remote metastases in more than 30 per cent. Tumor biology seems more important than size per se as regards disease course and outcome and thus also sets new demands on how to define an early pancreatic cancer. The data require novel... (More)

Pancreatic cancers are associated with poor survival and only some 10 per cent are resectable, but even in this subgroup recurrence is very frequent. The traditional view of sequential development of pancreatic cancer has been challenged by novel molecular biological findings, where the tumor quite rapidly might turn metastatic. In about 60 000 patients with diagnosed pancreatic cancer the association between tumor size, metastatic spread and survival was analyzed. Even the smallest tumors (<0.5 cm) had remote metastases in more than 30 per cent. Tumor biology seems more important than size per se as regards disease course and outcome and thus also sets new demands on how to define an early pancreatic cancer. The data require novel types of biomarkers/panels in serum and cancer tissue in order to take tumor biology into consideration to achieve improved personalized and more effective management of pancreatic cancer patients.

(Less)
Please use this url to cite or link to this publication:
author
organization
alternative title
Metastatic ability occurs already early on in pancreatic cancer
publishing date
type
Contribution to journal
publication status
published
subject
in
Lakartidningen
volume
114
issue
14
external identifiers
  • scopus:85017205809
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
50e5ec35-7789-4dc4-aa24-1cb308b4181e
date added to LUP
2017-05-23 11:50:39
date last changed
2017-05-24 12:34:50
@article{50e5ec35-7789-4dc4-aa24-1cb308b4181e,
  abstract     = {<p>Pancreatic cancers are associated with poor survival and only some 10 per cent are resectable, but even in this subgroup recurrence is very frequent. The traditional view of sequential development of pancreatic cancer has been challenged by novel molecular biological findings, where the tumor quite rapidly might turn metastatic. In about 60 000 patients with diagnosed pancreatic cancer the association between tumor size, metastatic spread and survival was analyzed. Even the smallest tumors (&lt;0.5 cm) had remote metastases in more than 30 per cent. Tumor biology seems more important than size per se as regards disease course and outcome and thus also sets new demands on how to define an early pancreatic cancer. The data require novel types of biomarkers/panels in serum and cancer tissue in order to take tumor biology into consideration to achieve improved personalized and more effective management of pancreatic cancer patients.</p>},
  author       = {Andersson, Roland},
  issn         = {0023-7205},
  language     = {swe},
  number       = {14},
  series       = {Lakartidningen},
  title        = {Pankreascancer kan metastasera tidigt : Tumörbiologi tycks viktigare än tumörstorlek},
  volume       = {114},
  year         = {2017},
}