Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Modernizing diagnosis of Alzheimer's disease : A review of global trends and Asia-specific perspectives

Iwatsubo, Takeshi ; Sperling, Reisa A. ; Algeciras-Schimnich, Alicia ; Arai, Hidenori ; Barron, Anna M. ; Benzinger, Tammie L.S. ; Carrillo, Maria C. ; Chen, Christopher ; Choi, Seong Hye and Fontana, Igor C. , et al. (2025) In Alzheimer's and Dementia 21(8).
Abstract

The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease-modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment-induced changes in disease biology. These frameworks enable opportunities for personalized interventions—encompassing pharmacological and non-pharmacological strategies—and for enhanced clinical trial design. However, implementing these advancements globally is influenced by diverse cultural, infrastructural, and regulatory factors. The 2024 Alzheimer's Association International Conference Advancements: Modernizing... (More)

The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease-modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment-induced changes in disease biology. These frameworks enable opportunities for personalized interventions—encompassing pharmacological and non-pharmacological strategies—and for enhanced clinical trial design. However, implementing these advancements globally is influenced by diverse cultural, infrastructural, and regulatory factors. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis, held in Japan, provided a unique platform to explore these global dynamics, particularly from an Asian perspective. This article highlights key discussions from the conference, exploring the role of biomarker-based diagnostic frameworks in shaping the future of AD/ADRD research, diagnosis, and treatment. We highlight regional challenges and successes and emphasize ethical considerations and practical strategies needed to ensure equitable access to diagnostic and therapeutic innovations. Highlights: Advances in biomarkers are reshaping Alzheimer's disease diagnosis and treatment. Modern diagnostic frameworks highlight biological precision, early detection, and dynamic frameworks. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis explored challenges and opportunities in global biomarker implementation. The conference explored geographic-specific impacts, focusing on Asia.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, Asia, biomarker, dementia, diagnosis
in
Alzheimer's and Dementia
volume
21
issue
8
article number
e70536
publisher
Wiley
external identifiers
  • pmid:40760693
  • scopus:105012409918
ISSN
1552-5260
DOI
10.1002/alz.70536
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
id
5100329e-ae32-4c99-bb58-b9d8ed046152
date added to LUP
2025-12-04 16:02:27
date last changed
2025-12-05 15:52:21
@article{5100329e-ae32-4c99-bb58-b9d8ed046152,
  abstract     = {{<p>The landscape of Alzheimer's disease (AD) and related dementias (ADRD) diagnosis is evolving rapidly, driven by advances in disease understanding, biomarker tools, and disease-modifying therapies. Modern diagnostic approaches emphasize biological precision, early detection, and dynamic frameworks that adapt to treatment-induced changes in disease biology. These frameworks enable opportunities for personalized interventions—encompassing pharmacological and non-pharmacological strategies—and for enhanced clinical trial design. However, implementing these advancements globally is influenced by diverse cultural, infrastructural, and regulatory factors. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis, held in Japan, provided a unique platform to explore these global dynamics, particularly from an Asian perspective. This article highlights key discussions from the conference, exploring the role of biomarker-based diagnostic frameworks in shaping the future of AD/ADRD research, diagnosis, and treatment. We highlight regional challenges and successes and emphasize ethical considerations and practical strategies needed to ensure equitable access to diagnostic and therapeutic innovations. Highlights: Advances in biomarkers are reshaping Alzheimer's disease diagnosis and treatment. Modern diagnostic frameworks highlight biological precision, early detection, and dynamic frameworks. The 2024 Alzheimer's Association International Conference Advancements: Modernizing Diagnosis explored challenges and opportunities in global biomarker implementation. The conference explored geographic-specific impacts, focusing on Asia.</p>}},
  author       = {{Iwatsubo, Takeshi and Sperling, Reisa A. and Algeciras-Schimnich, Alicia and Arai, Hidenori and Barron, Anna M. and Benzinger, Tammie L.S. and Carrillo, Maria C. and Chen, Christopher and Choi, Seong Hye and Fontana, Igor C. and Graff-Radford, Jonathan and Grill, Joshua D. and Heidebrink, Judith and Hu, Chaur Jong and Ihara, Ryoko and Ikeuchi, Takeshi and Iwata, Atsushi and Ip, Fanny C.F. and Fitri, Fasihah Irfani and Jack, Clifford R. and Jeong, Jee Hyang and Jia, Jianping and Kandiah, Nagaendran and Kim, Sang Yun and Kowa, Hisatomo and La Joie, Renaud and Niimi, Yoshiki and Noritake, Ryoji and Okonkwo, Ozioma C. and Palmqvist, Sebastian and Rafii, Michael S. and Raman, Rema and Shen, Yong and Simuni, Tanya and Snyder, Heather M. and Sriwannopas, Orapitchaya and Stoeckel, Luke E. and van der Flier, Wiesje M. and Wang, Huali and Wilcock, Donna M. and Zetterberg, Henrik and Zhou, Jin and Mahinrad, Simin and Sexton, Claire E.}},
  issn         = {{1552-5260}},
  keywords     = {{Alzheimer's disease; Asia; biomarker; dementia; diagnosis}},
  language     = {{eng}},
  number       = {{8}},
  publisher    = {{Wiley}},
  series       = {{Alzheimer's and Dementia}},
  title        = {{Modernizing diagnosis of Alzheimer's disease : A review of global trends and Asia-specific perspectives}},
  url          = {{http://dx.doi.org/10.1002/alz.70536}},
  doi          = {{10.1002/alz.70536}},
  volume       = {{21}},
  year         = {{2025}},
}