Patterns and dietary determinants of essential and toxic elements in blood measured in mid-pregnancy : The Norwegian Environmental Biobank
(2019) In Science of the Total Environment 671. p.299-308- Abstract
Background: Inadequate stores or intakes of essential minerals in pregnancy, or too high exposure to both toxic and essential elements, can have adverse effects on mother and child. The main aims of this study were to 1) describe the concentrations and patterns of essential and toxic elements measured in maternal whole blood during pregnancy; 2) identify dietary, lifestyle and sociodemographic determinants of element status; and 3) explore the impact of iron deficiency on blood element concentrations. Methods: This study is based on blood samples collected from 2982 women in gestational week 18 in The Norwegian Mother and Child Cohort study (MoBa) which were analyzed as part of the Norwegian Environmental Biobank. We derived blood... (More)
Background: Inadequate stores or intakes of essential minerals in pregnancy, or too high exposure to both toxic and essential elements, can have adverse effects on mother and child. The main aims of this study were to 1) describe the concentrations and patterns of essential and toxic elements measured in maternal whole blood during pregnancy; 2) identify dietary, lifestyle and sociodemographic determinants of element status; and 3) explore the impact of iron deficiency on blood element concentrations. Methods: This study is based on blood samples collected from 2982 women in gestational week 18 in The Norwegian Mother and Child Cohort study (MoBa) which were analyzed as part of the Norwegian Environmental Biobank. We derived blood element patterns by exploratory factor analysis, and associations between blood element patterns and diet were explored using sparse partial least squares (sPLS) regression. Results: Blood concentrations were determined for the essential elements (in the order of most abundant) Zn > Cu > Se > Mn > Mo > Co, and the toxic metals Pb > As > Hg > Cd > Tl. The concentrations were in ranges that were similar to or sometimes more favorable than in other pregnant and non-pregnant European women. We identified two blood element patterns; one including Zn, Se and Mn and another including Hg and As. For the Zn-Se-Mn pattern, use of multimineral supplements was the most important dietary determinant, while a high score in the Hg-As pattern was mainly determined by seafood consumption. Concentrations of Mn, Cd and Co were significantly higher in women with iron deficiency (plasma ferritin < 12 μg/L) than in women with plasma ferritin ≥ 12 μg/L. Conclusion: Our study illustrates complex relationships and coexistence of essential and toxic elements. Their potential interplay adds to the challenges of studies investigating health effects related to either diet or toxicants.
(Less)
- author
- Caspersen, Ida Henriette ; Thomsen, Cathrine ; Haug, Line Småstuen ; Knutsen, Helle K. ; Brantsæter, Anne Lise ; Papadopoulou, Eleni ; Erlund, Iris ; Lundh, Thomas LU ; Alexander, Jan and Meltzer, Helle Margrete
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Dietary exposure, Essential nutrients, Heavy metals, Iron deficiency, MoBa, The Norwegian Mother and Child Cohort Study
- in
- Science of the Total Environment
- volume
- 671
- pages
- 10 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85063453434
- pmid:30928759
- ISSN
- 0048-9697
- DOI
- 10.1016/j.scitotenv.2019.03.291
- language
- English
- LU publication?
- yes
- id
- 5119a4c1-1ce4-4af9-bc01-e784f7b44b8d
- date added to LUP
- 2019-04-05 12:07:18
- date last changed
- 2024-05-15 03:57:55
@article{5119a4c1-1ce4-4af9-bc01-e784f7b44b8d,
abstract = {{<p>Background: Inadequate stores or intakes of essential minerals in pregnancy, or too high exposure to both toxic and essential elements, can have adverse effects on mother and child. The main aims of this study were to 1) describe the concentrations and patterns of essential and toxic elements measured in maternal whole blood during pregnancy; 2) identify dietary, lifestyle and sociodemographic determinants of element status; and 3) explore the impact of iron deficiency on blood element concentrations. Methods: This study is based on blood samples collected from 2982 women in gestational week 18 in The Norwegian Mother and Child Cohort study (MoBa) which were analyzed as part of the Norwegian Environmental Biobank. We derived blood element patterns by exploratory factor analysis, and associations between blood element patterns and diet were explored using sparse partial least squares (sPLS) regression. Results: Blood concentrations were determined for the essential elements (in the order of most abundant) Zn > Cu > Se > Mn > Mo > Co, and the toxic metals Pb > As > Hg > Cd > Tl. The concentrations were in ranges that were similar to or sometimes more favorable than in other pregnant and non-pregnant European women. We identified two blood element patterns; one including Zn, Se and Mn and another including Hg and As. For the Zn-Se-Mn pattern, use of multimineral supplements was the most important dietary determinant, while a high score in the Hg-As pattern was mainly determined by seafood consumption. Concentrations of Mn, Cd and Co were significantly higher in women with iron deficiency (plasma ferritin < 12 μg/L) than in women with plasma ferritin ≥ 12 μg/L. Conclusion: Our study illustrates complex relationships and coexistence of essential and toxic elements. Their potential interplay adds to the challenges of studies investigating health effects related to either diet or toxicants.</p>}},
author = {{Caspersen, Ida Henriette and Thomsen, Cathrine and Haug, Line Småstuen and Knutsen, Helle K. and Brantsæter, Anne Lise and Papadopoulou, Eleni and Erlund, Iris and Lundh, Thomas and Alexander, Jan and Meltzer, Helle Margrete}},
issn = {{0048-9697}},
keywords = {{Dietary exposure; Essential nutrients; Heavy metals; Iron deficiency; MoBa; The Norwegian Mother and Child Cohort Study}},
language = {{eng}},
pages = {{299--308}},
publisher = {{Elsevier}},
series = {{Science of the Total Environment}},
title = {{Patterns and dietary determinants of essential and toxic elements in blood measured in mid-pregnancy : The Norwegian Environmental Biobank}},
url = {{http://dx.doi.org/10.1016/j.scitotenv.2019.03.291}},
doi = {{10.1016/j.scitotenv.2019.03.291}},
volume = {{671}},
year = {{2019}},
}