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Respiratory tract deposition of inhaled wood smoke particles in healthy volunteers

Muala, Ala; Nicklasson, Hanna LU ; Boman, Christoffer; Swietlicki, Erik LU ; Nyström, Robin; Pettersson, Esbjörn; Bosson, Jenny A; Rissler, Jenny LU ; Blomberg, Anders and Sandström, Thomas, et al. (2015) In Journal of Aerosol Medicine and Pulmonary Drug Delivery 28(4). p.237-246
Abstract
Background: Respiratory tract deposition of air pollution particles is a key to their adverse health effects. This study was aimed to determine the size-resolved deposition fraction (DF) of sooty wood smoke particles in the lungs of healthy subjects. The type of wood smoke investigated is typical for household air pollution from solid fuels, which is among the largest environmental health problems globally.



Methods: Twelve healthy volunteers inhaled diluted wood smoke from incomplete soot-rich combustion in a common wood stove. The DF of smoke particles (10–500 nm) was measured during three 15-min exposures in each subject during spontaneous breathing. Lung function was measured using standard spirometry.

... (More)
Background: Respiratory tract deposition of air pollution particles is a key to their adverse health effects. This study was aimed to determine the size-resolved deposition fraction (DF) of sooty wood smoke particles in the lungs of healthy subjects. The type of wood smoke investigated is typical for household air pollution from solid fuels, which is among the largest environmental health problems globally.



Methods: Twelve healthy volunteers inhaled diluted wood smoke from incomplete soot-rich combustion in a common wood stove. The DF of smoke particles (10–500 nm) was measured during three 15-min exposures in each subject during spontaneous breathing. Lung function was measured using standard spirometry.



Results: The total DFs by particle number concentration were 0.34±0.08. This can be compared with DFs of 0.21–0.23 in healthy subjects during previous experiments with wood pellet combustion. For particle mass, the total DFs found in this study were 0.22±0.06. DF and breathing frequency were negatively correlated as expected from model calculations (p<0.01).



Conclusions: The DF of the investigated sooty wood smoke particles was higher than for previously investigated particles generated during more efficient combustion of biomass. Together with toxicological studies, which have indicated that incomplete biomass combustion particles rich in soot and polycyclic aromatic hydrocarbons (PAHs) are especially harmful, these data highlight the health risks of inadequate wood combustion. (Less)
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type
Contribution to journal
publication status
published
subject
in
Journal of Aerosol Medicine and Pulmonary Drug Delivery
volume
28
issue
4
pages
237 - 246
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000359795000001
  • scopus:84938294704
ISSN
1941-2703
DOI
10.1089/jamp.2014.1122
language
English
LU publication?
yes
id
c763899a-6b77-4067-bd0b-fd1833fb7b2a (old id 5141809)
date added to LUP
2015-02-27 14:17:14
date last changed
2017-06-25 03:23:48
@article{c763899a-6b77-4067-bd0b-fd1833fb7b2a,
  abstract     = {Background: Respiratory tract deposition of air pollution particles is a key to their adverse health effects. This study was aimed to determine the size-resolved deposition fraction (DF) of sooty wood smoke particles in the lungs of healthy subjects. The type of wood smoke investigated is typical for household air pollution from solid fuels, which is among the largest environmental health problems globally.<br/><br>
<br/><br>
Methods: Twelve healthy volunteers inhaled diluted wood smoke from incomplete soot-rich combustion in a common wood stove. The DF of smoke particles (10–500 nm) was measured during three 15-min exposures in each subject during spontaneous breathing. Lung function was measured using standard spirometry.<br/><br>
<br/><br>
Results: The total DFs by particle number concentration were 0.34±0.08. This can be compared with DFs of 0.21–0.23 in healthy subjects during previous experiments with wood pellet combustion. For particle mass, the total DFs found in this study were 0.22±0.06. DF and breathing frequency were negatively correlated as expected from model calculations (p&lt;0.01).<br/><br>
<br/><br>
Conclusions: The DF of the investigated sooty wood smoke particles was higher than for previously investigated particles generated during more efficient combustion of biomass. Together with toxicological studies, which have indicated that incomplete biomass combustion particles rich in soot and polycyclic aromatic hydrocarbons (PAHs) are especially harmful, these data highlight the health risks of inadequate wood combustion.},
  author       = {Muala, Ala and Nicklasson, Hanna and Boman, Christoffer and Swietlicki, Erik and Nyström, Robin and Pettersson, Esbjörn and Bosson, Jenny A and Rissler, Jenny and Blomberg, Anders and Sandström, Thomas and Löndahl, Jakob},
  issn         = {1941-2703},
  language     = {eng},
  number       = {4},
  pages        = {237--246},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Journal of Aerosol Medicine and Pulmonary Drug Delivery},
  title        = {Respiratory tract deposition of inhaled wood smoke particles in healthy volunteers},
  url          = {http://dx.doi.org/10.1089/jamp.2014.1122},
  volume       = {28},
  year         = {2015},
}