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The role of pallidal serotonergic function in Parkinson's disease dyskinesias: a positron emission tomography study.

Smith, Ruben LU ; Wu, Kit; Hart, Thomas; Loane, Clare; Brooks, David J; Björklund, Anders LU ; Odin, Per LU ; Piccini, Paola and Politis, Marios (2015) In Neurobiology of Aging 36(4). p.1736-1742
Abstract
We have investigated the role of globus pallidus (GP) serotonergic terminals in the development of levodopa-induced dyskinesias (LIDs) in Parkinson's disease (PD). We studied 12 PD patients without LIDs, 12 PD patients with LIDs, and 12 healthy control subjects. We used (11)C-DASB positron emission tomography (PET), a marker of serotonin transporter availability, and (11)C-raclopride PET to measure changes in synaptic dopamine levels following levodopa administration. PD patients without LIDs showed a significant reduction of GP serotonin transporter binding compared with healthy controls although this was within the normal range in PD patients with LIDs. Levels of GP serotonin transporter binding correlated positively with severity of... (More)
We have investigated the role of globus pallidus (GP) serotonergic terminals in the development of levodopa-induced dyskinesias (LIDs) in Parkinson's disease (PD). We studied 12 PD patients without LIDs, 12 PD patients with LIDs, and 12 healthy control subjects. We used (11)C-DASB positron emission tomography (PET), a marker of serotonin transporter availability, and (11)C-raclopride PET to measure changes in synaptic dopamine levels following levodopa administration. PD patients without LIDs showed a significant reduction of GP serotonin transporter binding compared with healthy controls although this was within the normal range in PD patients with LIDs. Levels of GP serotonin transporter binding correlated positively with severity of dyskinesias. (11)C-raclopride PET detected a significant rise in GP synaptic dopamine levels of patients with LIDs after a levodopa challenge but not in patients with a stable response. Our findings indicate that LIDs in PD are associated with higher GP serotonergic function. This increased serotonin function may result in further dysregulation of thalamocortical signals and so promote the expression of dyskinesias. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Neurobiology of Aging
volume
36
issue
4
pages
1736 - 1742
publisher
Elsevier
external identifiers
  • pmid:25649022
  • wos:000355095300014
  • scopus:84925237392
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2014.12.037
language
English
LU publication?
yes
id
b40281d0-37a1-4f86-b444-1768959e0862 (old id 5145518)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25649022?dopt=Abstract
date added to LUP
2015-03-04 14:52:54
date last changed
2017-11-05 03:01:16
@article{b40281d0-37a1-4f86-b444-1768959e0862,
  abstract     = {We have investigated the role of globus pallidus (GP) serotonergic terminals in the development of levodopa-induced dyskinesias (LIDs) in Parkinson's disease (PD). We studied 12 PD patients without LIDs, 12 PD patients with LIDs, and 12 healthy control subjects. We used (11)C-DASB positron emission tomography (PET), a marker of serotonin transporter availability, and (11)C-raclopride PET to measure changes in synaptic dopamine levels following levodopa administration. PD patients without LIDs showed a significant reduction of GP serotonin transporter binding compared with healthy controls although this was within the normal range in PD patients with LIDs. Levels of GP serotonin transporter binding correlated positively with severity of dyskinesias. (11)C-raclopride PET detected a significant rise in GP synaptic dopamine levels of patients with LIDs after a levodopa challenge but not in patients with a stable response. Our findings indicate that LIDs in PD are associated with higher GP serotonergic function. This increased serotonin function may result in further dysregulation of thalamocortical signals and so promote the expression of dyskinesias.},
  author       = {Smith, Ruben and Wu, Kit and Hart, Thomas and Loane, Clare and Brooks, David J and Björklund, Anders and Odin, Per and Piccini, Paola and Politis, Marios},
  issn         = {1558-1497},
  language     = {eng},
  number       = {4},
  pages        = {1736--1742},
  publisher    = {Elsevier},
  series       = {Neurobiology of Aging},
  title        = {The role of pallidal serotonergic function in Parkinson's disease dyskinesias: a positron emission tomography study.},
  url          = {http://dx.doi.org/10.1016/j.neurobiolaging.2014.12.037},
  volume       = {36},
  year         = {2015},
}