Effects of autism spectrum disorders on outcome in teenage-onset anorexia nervosa evaluated by the Morgan-Russell outcome assessment schedule: a controlled community-based study
Nielsen, Sara ; Anckarsäter, Henrik LU ; Gillberg, Carina ; Gillberg, Christopher ; Råstam, Maria LU
and Wentz, Elisabet
(2015)
In Molecular Autism
6(14).
- Abstract
- Background: The purpose of the study was to evaluate time trends and effects of co-existing autism spectrum
disorders (ASD) on outcome in an ongoing long-term follow-up study of anorexia nervosa (AN).
Methods: The Morgan-Russell Outcome Assessment Schedule (MROAS) was used at 6-, 10- and 18-year follow-up
of a representative sample of 51 individuals with teenage-onset AN and a matched group of 51 healthy comparison
cases. The full multinomial distribution of responses for the full scale and each of the subscales was evaluated using
exact nonparametric statistical methods. The impact of diagnostic stability of ASD on outcome in AN was evaluated
in a dose–response model.
Results:... (More) - Background: The purpose of the study was to evaluate time trends and effects of co-existing autism spectrum
disorders (ASD) on outcome in an ongoing long-term follow-up study of anorexia nervosa (AN).
Methods: The Morgan-Russell Outcome Assessment Schedule (MROAS) was used at 6-, 10- and 18-year follow-up
of a representative sample of 51 individuals with teenage-onset AN and a matched group of 51 healthy comparison
cases. The full multinomial distribution of responses for the full scale and each of the subscales was evaluated using
exact nonparametric statistical methods. The impact of diagnostic stability of ASD on outcome in AN was evaluated
in a dose–response model.
Results: There were no deaths in either group. Food intake and menstrual pattern were initially poor in the AN
group but normalised over time. MROAS ‘mental state’ was much poorer in the AN group and did not improve
over time. The psychosexual MROAS domains ‘attitudes’ and ‘aims’ showed persistent problems in the AN group. In
the MROAS socioeconomic domain, the subscales ‘personal contacts’, ‘social activities’ and ‘employment record’ all
showed highly significant between-group differences at all three follow-ups. A statistically significant negative
dose–response relationship was found between a stable diagnosis of ASD over time and the results on the subscales
‘mental state’, ‘psychosexual state’ and ‘socio-economic state’.
Conclusions: Outcome of teenage-onset AN is favourable with respect to mortality and persisting eating disorder,
but serious problems remain in the domains ‘mental state’, ‘psychosexual function’ and ‘socioeconomic state’.
Outcome is considerably worse if ASD is present. Treatment programmes for AN need to be modified so as to
accommodate co-existing ASD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5156652
- author
- Nielsen, Sara
; Anckarsäter, Henrik
LU
; Gillberg, Carina
; Gillberg, Christopher
; Råstam, Maria
LU
and Wentz, Elisabet
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Anorexia nervosa, Autism spectrum disorders, Long-term outcome, Psychosexual, Community-based, Prospective, Controlled
- in
- Molecular Autism
- volume
- 6
- issue
- 14
- article number
- 14
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000351037300001
- pmid:25774282
- scopus:84924986016
- pmid:25774282
- ISSN
- 2040-2392
- DOI
- 10.1186/s13229-015-0013-4
- language
- English
- LU publication?
- yes
- id
- dd0168dc-5b1a-4711-af5e-7490d5ccafc5 (old id 5156652)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25774282?dopt=Abstract
- date added to LUP
- 2016-04-01 13:24:58
- date last changed
- 2022-04-21 21:36:10
@article{dd0168dc-5b1a-4711-af5e-7490d5ccafc5,
abstract = {{Background: The purpose of the study was to evaluate time trends and effects of co-existing autism spectrum<br/><br>
disorders (ASD) on outcome in an ongoing long-term follow-up study of anorexia nervosa (AN).<br/><br>
Methods: The Morgan-Russell Outcome Assessment Schedule (MROAS) was used at 6-, 10- and 18-year follow-up<br/><br>
of a representative sample of 51 individuals with teenage-onset AN and a matched group of 51 healthy comparison<br/><br>
cases. The full multinomial distribution of responses for the full scale and each of the subscales was evaluated using<br/><br>
exact nonparametric statistical methods. The impact of diagnostic stability of ASD on outcome in AN was evaluated<br/><br>
in a dose–response model.<br/><br>
Results: There were no deaths in either group. Food intake and menstrual pattern were initially poor in the AN<br/><br>
group but normalised over time. MROAS ‘mental state’ was much poorer in the AN group and did not improve<br/><br>
over time. The psychosexual MROAS domains ‘attitudes’ and ‘aims’ showed persistent problems in the AN group. In<br/><br>
the MROAS socioeconomic domain, the subscales ‘personal contacts’, ‘social activities’ and ‘employment record’ all<br/><br>
showed highly significant between-group differences at all three follow-ups. A statistically significant negative<br/><br>
dose–response relationship was found between a stable diagnosis of ASD over time and the results on the subscales<br/><br>
‘mental state’, ‘psychosexual state’ and ‘socio-economic state’.<br/><br>
Conclusions: Outcome of teenage-onset AN is favourable with respect to mortality and persisting eating disorder,<br/><br>
but serious problems remain in the domains ‘mental state’, ‘psychosexual function’ and ‘socioeconomic state’.<br/><br>
Outcome is considerably worse if ASD is present. Treatment programmes for AN need to be modified so as to<br/><br>
accommodate co-existing ASD.}},
author = {{Nielsen, Sara and Anckarsäter, Henrik and Gillberg, Carina and Gillberg, Christopher and Råstam, Maria and Wentz, Elisabet}},
issn = {{2040-2392}},
keywords = {{Anorexia nervosa; Autism spectrum disorders; Long-term outcome; Psychosexual; Community-based; Prospective; Controlled}},
language = {{eng}},
number = {{14}},
publisher = {{BioMed Central (BMC)}},
series = {{Molecular Autism}},
title = {{Effects of autism spectrum disorders on outcome in teenage-onset anorexia nervosa evaluated by the Morgan-Russell outcome assessment schedule: a controlled community-based study}},
url = {{https://lup.lub.lu.se/search/files/3355770/5275187.pdf}},
doi = {{10.1186/s13229-015-0013-4}},
volume = {{6}},
year = {{2015}},
}