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Development of a 3-dimensional tissue lung phantom of a preterm infant for optical measurements of oxygen—Laser-detector position considerations

Larsson, Jim LU ; Liao, Peilang; Lundin, Patrik LU ; Krite Svanberg, Emilie LU ; Swartling, Johannes LU ; Lewander Xu, Märta; Bood, Joakim LU and Andersson-Engels, Stefan LU (2018) In Journal of Biophotonics 11(3).
Abstract

There is a need to further improve the clinical care of our most vulnerable patients—preterm infants. Novel diagnostic and treatment tools facilitate such advances. Here, we evaluate a potential percutaneous optical monitoring tool to assess the oxygen and water vapor content in the lungs of preterm babies. The aim is to prepare for further clinical studies by gaining a detailed understanding of how the measured light intensity and gas absorption signal behave for different possible geometries of light delivery and receiver. Such an experimental evaluation is conducted for the first time utilizing a specially developed 3-dimensional-printed optical phantom based on a geometry model obtained from computer tomography images of the thorax... (More)

There is a need to further improve the clinical care of our most vulnerable patients—preterm infants. Novel diagnostic and treatment tools facilitate such advances. Here, we evaluate a potential percutaneous optical monitoring tool to assess the oxygen and water vapor content in the lungs of preterm babies. The aim is to prepare for further clinical studies by gaining a detailed understanding of how the measured light intensity and gas absorption signal behave for different possible geometries of light delivery and receiver. Such an experimental evaluation is conducted for the first time utilizing a specially developed 3-dimensional-printed optical phantom based on a geometry model obtained from computer tomography images of the thorax (chest) of a 1700-g premature infant. The measurements yield reliable signals for source–detector distances up to about 50 mm, with stronger gas absorption signals at long separations and positions related to the lower part of the lung, consistent with a larger relative volume of this. The limitations of this study include the omission of scattering tissue within the lungs and that similar optical properties are used for the wavelengths employed for the 2 gases, yielding no indication on the optimal wavelength pair to use.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
premature infants, respiratory distress syndrome, tissue phantom, tunable diode laser absorption spectroscopy
in
Journal of Biophotonics
volume
11
issue
3
publisher
John Wiley & Sons
external identifiers
  • scopus:85040343860
ISSN
1864-063X
DOI
10.1002/jbio.201700097
language
English
LU publication?
yes
id
515a92da-4117-43f4-9bf6-9ce5b0f53c1c
date added to LUP
2018-03-28 10:54:18
date last changed
2019-02-20 11:12:20
@article{515a92da-4117-43f4-9bf6-9ce5b0f53c1c,
  abstract     = {<p>There is a need to further improve the clinical care of our most vulnerable patients—preterm infants. Novel diagnostic and treatment tools facilitate such advances. Here, we evaluate a potential percutaneous optical monitoring tool to assess the oxygen and water vapor content in the lungs of preterm babies. The aim is to prepare for further clinical studies by gaining a detailed understanding of how the measured light intensity and gas absorption signal behave for different possible geometries of light delivery and receiver. Such an experimental evaluation is conducted for the first time utilizing a specially developed 3-dimensional-printed optical phantom based on a geometry model obtained from computer tomography images of the thorax (chest) of a 1700-g premature infant. The measurements yield reliable signals for source–detector distances up to about 50 mm, with stronger gas absorption signals at long separations and positions related to the lower part of the lung, consistent with a larger relative volume of this. The limitations of this study include the omission of scattering tissue within the lungs and that similar optical properties are used for the wavelengths employed for the 2 gases, yielding no indication on the optimal wavelength pair to use.</p>},
  articleno    = {e201700097},
  author       = {Larsson, Jim and Liao, Peilang and Lundin, Patrik and Krite Svanberg, Emilie and Swartling, Johannes and Lewander Xu, Märta and Bood, Joakim and Andersson-Engels, Stefan},
  issn         = {1864-063X},
  keyword      = {premature infants,respiratory distress syndrome,tissue phantom,tunable diode laser absorption spectroscopy},
  language     = {eng},
  month        = {03},
  number       = {3},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Biophotonics},
  title        = {Development of a 3-dimensional tissue lung phantom of a preterm infant for optical measurements of oxygen—Laser-detector position considerations},
  url          = {http://dx.doi.org/10.1002/jbio.201700097},
  volume       = {11},
  year         = {2018},
}