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Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland

Hoyer, Birgit Bjerre; Ramlau-Hansen, Cecilia Host; Pedersen, Henning Sloth; Goralczyk, Katarzyna; Chumak, Lyubov; Jönsson, Bo A LU ; Bonde, Jens Peter and Toft, Gunnar (2015) In BMC Public Health 15(146). p.1-11
Abstract
Background: Prior studies on the association between prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) and child motor development have found contradicting results. Using data collected in the INUENDO cohort in Kharkiv (Ukraine), Warsaw (Poland) and Greenland (N = 1,103) between the years 2002 and 2012, we examined relations of prenatal exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p, p'-DDE) and 2,2', 4,4', 5,5'-hexachlorobiphenyl (CB-153) on motor development and developmental milestones; crawling, standing-up and walking. Methods: CB-153 and p, p'-DDE were measured in maternal blood in second or third trimester of pregnancy. Motor development was measured in terms of the... (More)
Background: Prior studies on the association between prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) and child motor development have found contradicting results. Using data collected in the INUENDO cohort in Kharkiv (Ukraine), Warsaw (Poland) and Greenland (N = 1,103) between the years 2002 and 2012, we examined relations of prenatal exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p, p'-DDE) and 2,2', 4,4', 5,5'-hexachlorobiphenyl (CB-153) on motor development and developmental milestones; crawling, standing-up and walking. Methods: CB-153 and p, p'-DDE were measured in maternal blood in second or third trimester of pregnancy. Motor development was measured in terms of the parentally assessed screening tool Developmental Coordination Disorder Questionnaire 2007 and developmental milestones were assessed via retrospective parental reports of child age at the first time of crawling, standing-up and walking. Results: We saw no associations between tertiles of CB-153 and p, p'-DDE or log-transformed exposures and retrospective reports of the developmental milestones crawling, standing-up and walking in infancy or the motor skills measured as developmental coordination disorder at young school age. Conclusions: In utero exposure to CB-153 and p, p'-DDE was not associated with parentally retrospectively assessed developmental milestones in infancy or parentally assessed motor skills at young school age. The use of a more sensitive outcome measure may be warranted if subtle effects should be identified. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Child motor development, Developmental milestones, Dichlorodiphenyldichloroethylene (DDE), Organochlorines, Polychlorinated, biphenyls (PCBs), Prenatal exposure
in
BMC Public Health
volume
15
issue
146
pages
1 - 11
publisher
BioMed Central
external identifiers
  • wos:000349751800001
  • scopus:84924259349
  • pmid:25885170
ISSN
1471-2458
DOI
10.1186/s12889-015-1465-3
language
English
LU publication?
yes
id
5df68966-042a-4899-b49e-263c867d2eea (old id 5160154)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25885170?dopt=Abstract
date added to LUP
2015-05-05 14:43:46
date last changed
2017-01-01 06:19:55
@article{5df68966-042a-4899-b49e-263c867d2eea,
  abstract     = {Background: Prior studies on the association between prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) and child motor development have found contradicting results. Using data collected in the INUENDO cohort in Kharkiv (Ukraine), Warsaw (Poland) and Greenland (N = 1,103) between the years 2002 and 2012, we examined relations of prenatal exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p, p'-DDE) and 2,2', 4,4', 5,5'-hexachlorobiphenyl (CB-153) on motor development and developmental milestones; crawling, standing-up and walking. Methods: CB-153 and p, p'-DDE were measured in maternal blood in second or third trimester of pregnancy. Motor development was measured in terms of the parentally assessed screening tool Developmental Coordination Disorder Questionnaire 2007 and developmental milestones were assessed via retrospective parental reports of child age at the first time of crawling, standing-up and walking. Results: We saw no associations between tertiles of CB-153 and p, p'-DDE or log-transformed exposures and retrospective reports of the developmental milestones crawling, standing-up and walking in infancy or the motor skills measured as developmental coordination disorder at young school age. Conclusions: In utero exposure to CB-153 and p, p'-DDE was not associated with parentally retrospectively assessed developmental milestones in infancy or parentally assessed motor skills at young school age. The use of a more sensitive outcome measure may be warranted if subtle effects should be identified.},
  articleno    = {146},
  author       = {Hoyer, Birgit Bjerre and Ramlau-Hansen, Cecilia Host and Pedersen, Henning Sloth and Goralczyk, Katarzyna and Chumak, Lyubov and Jönsson, Bo A and Bonde, Jens Peter and Toft, Gunnar},
  issn         = {1471-2458},
  keyword      = {Child motor development,Developmental milestones,Dichlorodiphenyldichloroethylene (DDE),Organochlorines,Polychlorinated,biphenyls (PCBs),Prenatal exposure},
  language     = {eng},
  number       = {146},
  pages        = {1--11},
  publisher    = {BioMed Central},
  series       = {BMC Public Health},
  title        = {Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5-9 years in Greenland, Ukraine and Poland},
  url          = {http://dx.doi.org/10.1186/s12889-015-1465-3},
  volume       = {15},
  year         = {2015},
}