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Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease

Donahue, Manus J; Achten, Eric; Cogswell, Petrice M; De Leeuw, Frank-Erik; Derdeyn, Colin P; Dijkhuizen, Rick M; Fan, Audrey P; Ghaznawi, Rashid; Heit, Jeremy J and Ikram, M Arfan, et al. (2017) In Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Abstract

Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recovery mechanisms. Underlying pathophysiology as it relates to large vessel steno-occlusive disease and the impact of this macrovascular disease on tissue-level viability, hemodynamics (cerebral blood flow, cerebral blood volume, and mean transit time), and metabolism (cerebral metabolic rate of oxygen consumption and pH) are also discussed in the... (More)

Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recovery mechanisms. Underlying pathophysiology as it relates to large vessel steno-occlusive disease and the impact of this macrovascular disease on tissue-level viability, hemodynamics (cerebral blood flow, cerebral blood volume, and mean transit time), and metabolism (cerebral metabolic rate of oxygen consumption and pH) are also discussed in the context of emerging neuroimaging protocols with sensitivity to these factors. The overall purpose is to highlight advancements in stroke care and diagnostics and to provide a general overview of emerging research topics that have potential for reducing morbidity in multiple areas of CVD.

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Journal Article
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Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
publisher
Nature Publishing Group
external identifiers
  • scopus:85046007845
ISSN
1559-7016
DOI
10.1177/0271678X17721830
language
English
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yes
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516e4a20-8089-412c-b324-4a5e59a7bc6e
date added to LUP
2017-11-23 13:18:10
date last changed
2018-05-20 04:38:56
@article{516e4a20-8089-412c-b324-4a5e59a7bc6e,
  abstract     = {<p>Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization of post-stroke recovery mechanisms. Underlying pathophysiology as it relates to large vessel steno-occlusive disease and the impact of this macrovascular disease on tissue-level viability, hemodynamics (cerebral blood flow, cerebral blood volume, and mean transit time), and metabolism (cerebral metabolic rate of oxygen consumption and pH) are also discussed in the context of emerging neuroimaging protocols with sensitivity to these factors. The overall purpose is to highlight advancements in stroke care and diagnostics and to provide a general overview of emerging research topics that have potential for reducing morbidity in multiple areas of CVD.</p>},
  author       = {Donahue, Manus J and Achten, Eric and Cogswell, Petrice M and De Leeuw, Frank-Erik and Derdeyn, Colin P and Dijkhuizen, Rick M and Fan, Audrey P and Ghaznawi, Rashid and Heit, Jeremy J and Ikram, M Arfan and Jezzard, Peter and Jordan, Lori C and Jouvent, Eric and Knutsson, Linda and Leigh, Richard and Liebeskind, David S and Lin, Weili and Okell, Thomas W and Qureshi, Adnan I and Stagg, Charlotte J and van Osch, Matthias Jp and van Zijl, Peter Cm and Watchmaker, Jennifer M and Wintermark, Max and Wu, Ona and Zaharchuk, Greg and Zhou, Jinyuan and Hendrikse, Jeroen},
  issn         = {1559-7016},
  keyword      = {Journal Article},
  language     = {eng},
  month        = {01},
  publisher    = {Nature Publishing Group},
  series       = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  title        = {Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease},
  url          = {http://dx.doi.org/10.1177/0271678X17721830},
  year         = {2017},
}