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Generation of an integration-free induced pluripotent stem cell line (CSC-43J) from a patient with sporadic Parkinson's disease

Marote, Ana LU ; Pomeshchik, Yuriy LU ; Goldwurm, Stefano; Collin, Anna LU ; Lamas, Nuno J. LU ; Pinto, Luísa; Salgado, António J. and Roybon, Laurent LU (2018) In Stem Cell Research 27. p.82-85
Abstract

An induced pluripotent stem cell (iPSC) line was generated from a 36-year-old patient with sporadic Parkinson's disease (PD). Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated cell line (CSC-43) exhibits expression of common pluripotency markers, in vitro differentiation into three germ layers and normal karyotype. This iPSC line can be used to study the mechanisms underlying the development of PD.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Stem Cell Research
volume
27
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:85040374677
ISSN
1873-5061
DOI
10.1016/j.scr.2018.01.007
language
English
LU publication?
yes
id
5171f550-724d-4b35-b329-cbb973824f73
date added to LUP
2018-01-22 08:51:06
date last changed
2018-01-23 03:00:14
@article{5171f550-724d-4b35-b329-cbb973824f73,
  abstract     = {<p>An induced pluripotent stem cell (iPSC) line was generated from a 36-year-old patient with sporadic Parkinson's disease (PD). Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated cell line (CSC-43) exhibits expression of common pluripotency markers, in vitro differentiation into three germ layers and normal karyotype. This iPSC line can be used to study the mechanisms underlying the development of PD.</p>},
  author       = {Marote, Ana and Pomeshchik, Yuriy and Goldwurm, Stefano and Collin, Anna and Lamas, Nuno J. and Pinto, Luísa and Salgado, António J. and Roybon, Laurent},
  issn         = {1873-5061},
  language     = {eng},
  month        = {03},
  pages        = {82--85},
  publisher    = {Elsevier},
  series       = {Stem Cell Research},
  title        = {Generation of an integration-free induced pluripotent stem cell line (CSC-43J) from a patient with sporadic Parkinson's disease},
  url          = {http://dx.doi.org/10.1016/j.scr.2018.01.007},
  volume       = {27},
  year         = {2018},
}