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Resilience and Risk for Alcohol Use Disorders : A Swedish Twin Study

Long, Elizabeth C.; Larsson Lönn, Sara LU ; Ji, Jianguang LU ; Lichtenstein, Paul; Sundquist, Jan LU ; Sundquist, Kristina LU and Kendler, Kenneth S. (2017) In Alcoholism: Clinical and Experimental Research 41(1). p.149-155
Abstract

Background: Resilience has been shown to be protective against alcohol use disorders (AUDs), but the magnitude and nature of the relationship between these 2 phenotypes are not clear. The aim of this study was to examine the strength of this relationship and the degree to which it results from common genetic or common environmental influences. Methods: Resilience was assessed on a 9-point scale during a personal interview in 1,653,721 Swedish men aged 17 to 25 years. AUD was identified based on Swedish medical, legal, and pharmacy registries. The magnitude of the relationship between resilience and AUD was examined using logistic regression. The extent to which the relationship arises from common genetic or common environmental factors... (More)

Background: Resilience has been shown to be protective against alcohol use disorders (AUDs), but the magnitude and nature of the relationship between these 2 phenotypes are not clear. The aim of this study was to examine the strength of this relationship and the degree to which it results from common genetic or common environmental influences. Methods: Resilience was assessed on a 9-point scale during a personal interview in 1,653,721 Swedish men aged 17 to 25 years. AUD was identified based on Swedish medical, legal, and pharmacy registries. The magnitude of the relationship between resilience and AUD was examined using logistic regression. The extent to which the relationship arises from common genetic or common environmental factors was examined using a bivariate Cholesky decomposition model. Results: The 5 single items that comprised the resilience assessment (social maturity, interest, psychological energy, home environment, and emotional control) all reduced risk for subsequent AUD, with social maturity showing the strongest effect. The linear effect by logistic regression showed that a 1-point increase on the resilience scale was associated with a 29% decrease in odds of AUD. The Cholesky decomposition model demonstrated that the resilience–AUD relationship was largely attributable to overlapping genetic and shared environmental factors (57 and 36%, respectively). Conclusions: Resilience is strongly associated with a reduction in risk for AUD. This relationship appears to be the result of overlapping genetic and shared environmental influences that impact resilience and risk of AUD, rather than a directly causal relationship.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alcohol Use Disorder, Resilience, Twins
in
Alcoholism: Clinical and Experimental Research
volume
41
issue
1
pages
7 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85006893208
  • wos:000393890700016
ISSN
0145-6008
DOI
10.1111/acer.13274
language
English
LU publication?
yes
id
51727340-1104-4f75-81e6-82ea978609d8
date added to LUP
2017-01-13 15:29:28
date last changed
2018-01-07 11:45:05
@article{51727340-1104-4f75-81e6-82ea978609d8,
  abstract     = {<p>Background: Resilience has been shown to be protective against alcohol use disorders (AUDs), but the magnitude and nature of the relationship between these 2 phenotypes are not clear. The aim of this study was to examine the strength of this relationship and the degree to which it results from common genetic or common environmental influences. Methods: Resilience was assessed on a 9-point scale during a personal interview in 1,653,721 Swedish men aged 17 to 25 years. AUD was identified based on Swedish medical, legal, and pharmacy registries. The magnitude of the relationship between resilience and AUD was examined using logistic regression. The extent to which the relationship arises from common genetic or common environmental factors was examined using a bivariate Cholesky decomposition model. Results: The 5 single items that comprised the resilience assessment (social maturity, interest, psychological energy, home environment, and emotional control) all reduced risk for subsequent AUD, with social maturity showing the strongest effect. The linear effect by logistic regression showed that a 1-point increase on the resilience scale was associated with a 29% decrease in odds of AUD. The Cholesky decomposition model demonstrated that the resilience–AUD relationship was largely attributable to overlapping genetic and shared environmental factors (57 and 36%, respectively). Conclusions: Resilience is strongly associated with a reduction in risk for AUD. This relationship appears to be the result of overlapping genetic and shared environmental influences that impact resilience and risk of AUD, rather than a directly causal relationship.</p>},
  author       = {Long, Elizabeth C. and Larsson Lönn, Sara and Ji, Jianguang and Lichtenstein, Paul and Sundquist, Jan and Sundquist, Kristina and Kendler, Kenneth S.},
  issn         = {0145-6008},
  keyword      = {Alcohol Use Disorder,Resilience,Twins},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {149--155},
  publisher    = {Wiley-Blackwell},
  series       = {Alcoholism: Clinical and Experimental Research},
  title        = {Resilience and Risk for Alcohol Use Disorders : A Swedish Twin Study},
  url          = {http://dx.doi.org/10.1111/acer.13274},
  volume       = {41},
  year         = {2017},
}