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Plasma phosphorylated tau217 discordance with amyloid status in an ethnically diverse mixed memory clinic cohort

Kjaergaard, Daniel ; Nielsen, T. Rune ; Stomrud, Erik LU orcid ; Bali, Divya LU ; Clemmensen, Frederikke Kragh ; Frederiksen, Kristian Steen ; Gleerup, Helena Sophia ; Hasselbalch, Steen Gregers ; Janelidze, Shorena LU and Hansson, Oskar LU orcid , et al. (2026) In Journal of the Neurological Sciences 488.
Abstract

We characterized patients with discordant plasma p-tau217 results and amyloid status determined by the Aβ42/p-tau181 CSF ratio or Aβ-PET biomarkers in an ethnically diverse mixed memory clinic cohort. Among 539 patients, 83.9% had concordant biomarker profiles, while 13.4% were amyloid negative and plasma p-tau217 positive discordant, and 2.8% were amyloid positive and plasma p-tau217 negative discordant. Discordant groups differed in cognitive syndrome severity and etiological diagnosis, but no other variables reached significance. However, analyses indicated small effects of BMI, kidney function, and certain neurological conditions. Amyloid negativity and plasma p-tau217 positivity discordance may reflect plasma p-tau217 detecting... (More)

We characterized patients with discordant plasma p-tau217 results and amyloid status determined by the Aβ42/p-tau181 CSF ratio or Aβ-PET biomarkers in an ethnically diverse mixed memory clinic cohort. Among 539 patients, 83.9% had concordant biomarker profiles, while 13.4% were amyloid negative and plasma p-tau217 positive discordant, and 2.8% were amyloid positive and plasma p-tau217 negative discordant. Discordant groups differed in cognitive syndrome severity and etiological diagnosis, but no other variables reached significance. However, analyses indicated small effects of BMI, kidney function, and certain neurological conditions. Amyloid negativity and plasma p-tau217 positivity discordance may reflect plasma p-tau217 detecting early amyloid pathology not detected by CSF or Aβ-PET. Further research is needed to clarify mechanisms underlying discordant biomarker profiles.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, Biomarker, Confounders, Discordance, Diversity, Phosphorylated tau, Plasma
in
Journal of the Neurological Sciences
volume
488
article number
126057
publisher
Elsevier
external identifiers
  • pmid:42287769
  • scopus:105041538785
ISSN
0022-510X
DOI
10.1016/j.jns.2026.126057
language
English
LU publication?
yes
id
517dd8c1-4f3a-4990-a993-51165c0107e3
date added to LUP
2026-06-30 14:03:19
date last changed
2026-07-01 15:10:58
@article{517dd8c1-4f3a-4990-a993-51165c0107e3,
  abstract     = {{<p>We characterized patients with discordant plasma p-tau217 results and amyloid status determined by the Aβ42/p-tau181 CSF ratio or Aβ-PET biomarkers in an ethnically diverse mixed memory clinic cohort. Among 539 patients, 83.9% had concordant biomarker profiles, while 13.4% were amyloid negative and plasma p-tau217 positive discordant, and 2.8% were amyloid positive and plasma p-tau217 negative discordant. Discordant groups differed in cognitive syndrome severity and etiological diagnosis, but no other variables reached significance. However, analyses indicated small effects of BMI, kidney function, and certain neurological conditions. Amyloid negativity and plasma p-tau217 positivity discordance may reflect plasma p-tau217 detecting early amyloid pathology not detected by CSF or Aβ-PET. Further research is needed to clarify mechanisms underlying discordant biomarker profiles.</p>}},
  author       = {{Kjaergaard, Daniel and Nielsen, T. Rune and Stomrud, Erik and Bali, Divya and Clemmensen, Frederikke Kragh and Frederiksen, Kristian Steen and Gleerup, Helena Sophia and Hasselbalch, Steen Gregers and Janelidze, Shorena and Hansson, Oskar and Waldemar, Gunhild and Simonsen, Anja Hviid}},
  issn         = {{0022-510X}},
  keywords     = {{Alzheimer's disease; Biomarker; Confounders; Discordance; Diversity; Phosphorylated tau; Plasma}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Journal of the Neurological Sciences}},
  title        = {{Plasma phosphorylated tau217 discordance with amyloid status in an ethnically diverse mixed memory clinic cohort}},
  url          = {{http://dx.doi.org/10.1016/j.jns.2026.126057}},
  doi          = {{10.1016/j.jns.2026.126057}},
  volume       = {{488}},
  year         = {{2026}},
}