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PXL01 alters macrophage response with no effect on axonal outgrowth or Schwann cell response after nerve repair in rats

Hazer Rosberg, Derya Burcu LU orcid ; Stenberg, Lena LU orcid ; Mahlapuu, Margit and Dahlin, Lars B LU orcid (2024) In Regenerative Medicine 19(6). p.327-343
Abstract

Background: Adjunctive pharmacological treatment may improve nerve regeneration. We investigated nerve regeneration processes of PXL01 - a lactoferrin-derived peptide - after repair of the sciatic nerve in healthy Wistar rats. Materials & methods: PXL01, sodium hyaluronate (carrier) or sodium chloride was administered around the repair. After 6 days axonal outgrowth, Schwann cell response, pan- (CD68) and pro-healing (CD206) macrophages in sciatic nerve, sensory neuronal response in dorsal root ganglia (DRG) and expression of heat shock protein 27 (HSP27) in sciatic nerves and DRGs were analyzed. Results: Despite a lower number of pan-macrophages, other investigated variables in sciatic nerves or DRGs did not differ between the... (More)

Background: Adjunctive pharmacological treatment may improve nerve regeneration. We investigated nerve regeneration processes of PXL01 - a lactoferrin-derived peptide - after repair of the sciatic nerve in healthy Wistar rats. Materials & methods: PXL01, sodium hyaluronate (carrier) or sodium chloride was administered around the repair. After 6 days axonal outgrowth, Schwann cell response, pan- (CD68) and pro-healing (CD206) macrophages in sciatic nerve, sensory neuronal response in dorsal root ganglia (DRG) and expression of heat shock protein 27 (HSP27) in sciatic nerves and DRGs were analyzed. Results: Despite a lower number of pan-macrophages, other investigated variables in sciatic nerves or DRGs did not differ between the treatment groups. Conclusion: PLX01 applied locally inhibits inflammation through pan-macrophages in repaired sciatic nerves without any impact on nerve regeneration or pro-healing macrophages.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Schwann Cells/metabolism, Macrophages/metabolism, Nerve Regeneration/drug effects, Rats, Wistar, Sciatic Nerve/drug effects, Axons/drug effects, Rats, Ganglia, Spinal/drug effects, Male
in
Regenerative Medicine
volume
19
issue
6
pages
327 - 343
publisher
Taylor & Francis
external identifiers
  • scopus:85197420900
  • pmid:38957920
ISSN
1746-0751
DOI
10.1080/17460751.2024.2361515
language
English
LU publication?
yes
id
518188d6-6280-4af8-8d1a-adc5aa1e3b9e
date added to LUP
2024-11-12 09:00:57
date last changed
2025-07-09 23:55:11
@article{518188d6-6280-4af8-8d1a-adc5aa1e3b9e,
  abstract     = {{<p> Background: Adjunctive pharmacological treatment may improve nerve regeneration. We investigated nerve regeneration processes of PXL01 - a lactoferrin-derived peptide - after repair of the sciatic nerve in healthy Wistar rats. Materials &amp; methods: PXL01, sodium hyaluronate (carrier) or sodium chloride was administered around the repair. After 6 days axonal outgrowth, Schwann cell response, pan- (CD68) and pro-healing (CD206) macrophages in sciatic nerve, sensory neuronal response in dorsal root ganglia (DRG) and expression of heat shock protein 27 (HSP27) in sciatic nerves and DRGs were analyzed. Results: Despite a lower number of pan-macrophages, other investigated variables in sciatic nerves or DRGs did not differ between the treatment groups. Conclusion: PLX01 applied locally inhibits inflammation through pan-macrophages in repaired sciatic nerves without any impact on nerve regeneration or pro-healing macrophages. </p>}},
  author       = {{Hazer Rosberg, Derya Burcu and Stenberg, Lena and Mahlapuu, Margit and Dahlin, Lars B}},
  issn         = {{1746-0751}},
  keywords     = {{Animals; Schwann Cells/metabolism; Macrophages/metabolism; Nerve Regeneration/drug effects; Rats, Wistar; Sciatic Nerve/drug effects; Axons/drug effects; Rats; Ganglia, Spinal/drug effects; Male}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{6}},
  pages        = {{327--343}},
  publisher    = {{Taylor & Francis}},
  series       = {{Regenerative Medicine}},
  title        = {{PXL01 alters macrophage response with no effect on axonal outgrowth or Schwann cell response after nerve repair in rats}},
  url          = {{http://dx.doi.org/10.1080/17460751.2024.2361515}},
  doi          = {{10.1080/17460751.2024.2361515}},
  volume       = {{19}},
  year         = {{2024}},
}