Proteoglycans : a common portal for SARS-CoV-2 and extracellular vesicle uptake
(2023) In American journal of physiology. Cell physiology 324(1). p.76-84- Abstract
As structural components of the glycocalyx, heparan sulfate proteoglycans (HSPGs) are involved in multiple pathophysiological processes at the apex of cell signaling cascades, and as endocytosis receptors for particle structures, such as lipoproteins, extracellular vesicles, and enveloped viruses, including SARS-CoV-2. Given their diversity and complex biogenesis regulation, HSPGs remain understudied. Here we compile some of the latest studies focusing on HSPGs as internalizing receptors of extracellular vesicles ("endogenous virus") and SARS-CoV-2 lipid-enclosed particles and highlight similarities in their biophysical and structural characteristics. Specifically, the similarities in their biogenesis, size, and lipid composition may... (More)
As structural components of the glycocalyx, heparan sulfate proteoglycans (HSPGs) are involved in multiple pathophysiological processes at the apex of cell signaling cascades, and as endocytosis receptors for particle structures, such as lipoproteins, extracellular vesicles, and enveloped viruses, including SARS-CoV-2. Given their diversity and complex biogenesis regulation, HSPGs remain understudied. Here we compile some of the latest studies focusing on HSPGs as internalizing receptors of extracellular vesicles ("endogenous virus") and SARS-CoV-2 lipid-enclosed particles and highlight similarities in their biophysical and structural characteristics. Specifically, the similarities in their biogenesis, size, and lipid composition may explain a common dependence on HSPGs for efficient cell-surface attachment and uptake. We further discuss the relative complexity of extracellular vesicle composition and the viral mechanisms that evolve towards increased infectivity that complicate therapeutic strategies addressing blockade of their uptake.
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- author
- Cerezo-Magaña, Myriam LU ; Bång-Rudenstam, Anna LU and Belting, Mattias LU
- organization
- publishing date
- 2023-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cancer, COVID-19, extracellular vesicles, proteoglycans, SARS-CoV-2
- in
- American journal of physiology. Cell physiology
- volume
- 324
- issue
- 1
- pages
- 76 - 84
- publisher
- American Physiological Society
- external identifiers
-
- pmid:36458979
- scopus:85144593895
- ISSN
- 1522-1563
- DOI
- 10.1152/ajpcell.00453.2022
- language
- English
- LU publication?
- yes
- id
- 5185486f-8727-4463-81ee-41ecaa686e08
- date added to LUP
- 2023-02-03 13:57:38
- date last changed
- 2024-04-18 09:09:23
@article{5185486f-8727-4463-81ee-41ecaa686e08, abstract = {{<p>As structural components of the glycocalyx, heparan sulfate proteoglycans (HSPGs) are involved in multiple pathophysiological processes at the apex of cell signaling cascades, and as endocytosis receptors for particle structures, such as lipoproteins, extracellular vesicles, and enveloped viruses, including SARS-CoV-2. Given their diversity and complex biogenesis regulation, HSPGs remain understudied. Here we compile some of the latest studies focusing on HSPGs as internalizing receptors of extracellular vesicles ("endogenous virus") and SARS-CoV-2 lipid-enclosed particles and highlight similarities in their biophysical and structural characteristics. Specifically, the similarities in their biogenesis, size, and lipid composition may explain a common dependence on HSPGs for efficient cell-surface attachment and uptake. We further discuss the relative complexity of extracellular vesicle composition and the viral mechanisms that evolve towards increased infectivity that complicate therapeutic strategies addressing blockade of their uptake.</p>}}, author = {{Cerezo-Magaña, Myriam and Bång-Rudenstam, Anna and Belting, Mattias}}, issn = {{1522-1563}}, keywords = {{cancer; COVID-19; extracellular vesicles; proteoglycans; SARS-CoV-2}}, language = {{eng}}, month = {{01}}, number = {{1}}, pages = {{76--84}}, publisher = {{American Physiological Society}}, series = {{American journal of physiology. Cell physiology}}, title = {{Proteoglycans : a common portal for SARS-CoV-2 and extracellular vesicle uptake}}, url = {{http://dx.doi.org/10.1152/ajpcell.00453.2022}}, doi = {{10.1152/ajpcell.00453.2022}}, volume = {{324}}, year = {{2023}}, }