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Plasma carotenoids, vitamin C, retinol and tocopherols levels and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition: A nested case-control study Plasma micronutrients and pancreatic cancer risk

Jeurnink, Suzanne M.; Ros, Martine M.; Leenders, Max; van Duijnhoven, Franzel J. B.; Siersema, Peter D.; Jansen, Eugene H. J. M.; van Gils, Carla H.; Bakker, Marije F.; Overvad, Kim and Roswall, Nina, et al. (2015) In International Journal of Cancer 136(6). p.665-676
Abstract
Evidence of a protective effect of several antioxidants and other nutrients on pancreatic cancer risk is inconsistent. The aim of this study was to investigate the association for prediagnostic plasma levels of carotenoids, vitamin C, retinol and tocopherols with risk of pancreatic cancer in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). 446 incident exocrine pancreatic cancer cases were matched to 446 controls by age at blood collection, study center, sex, date and time of blood collection, fasting status and hormone use. Plasma carotenoids (- and -carotene, lycopene, -cryptoxanthin, canthaxanthin, zeaxanthin and lutein), - and -tocopherol and retinol were measured by reverse... (More)
Evidence of a protective effect of several antioxidants and other nutrients on pancreatic cancer risk is inconsistent. The aim of this study was to investigate the association for prediagnostic plasma levels of carotenoids, vitamin C, retinol and tocopherols with risk of pancreatic cancer in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). 446 incident exocrine pancreatic cancer cases were matched to 446 controls by age at blood collection, study center, sex, date and time of blood collection, fasting status and hormone use. Plasma carotenoids (- and -carotene, lycopene, -cryptoxanthin, canthaxanthin, zeaxanthin and lutein), - and -tocopherol and retinol were measured by reverse phase high-performance liquid chromatography and plasma vitamin C by a colorimetric assay. Incidence rate ratios (IRRs) with 95% confidence intervals (95%CIs) for pancreatic cancer risk were estimated using a conditional logistic regression analysis, adjusted for smoking status, smoking duration and intensity, waist circumference, cotinine levels and diabetes status. Inverse associations with pancreatic cancer risk were found for plasma -carotene (IRR highest vs. lowest quartile 0.52, 95%CI 0.31-0.88, p for trend=0.02), zeaxanthin (IRR highest vs. lowest quartile 0.53, 95%CI 0.30-0.94, p for trend=0.06) and -tocopherol (IRR highest vs. lowest quartile 0.62, 95%CI 0.39-0.99, p for trend=0.08. For - and -carotene, lutein, sum of carotenoids and -tocopherol, heterogeneity between geographical regions was observed. In conclusion, our results show that higher plasma concentrations of -carotene, zeaxanthin and -tocopherol may be inversely associated with risk of pancreatic cancer, but further studies are warranted. What's new? Fruits and vegetables may play a role in the prevention of pancreatic cancer, but associations between the antioxidants those foods contain and disease risk remain unclear. In this study, pancreatic cancer risk was inversely associated with increased prediagnostic plasma concentrations of the antioxidants -carotene, zeaxanthin, and -tocopherol. Geographic variations were also detected. In Northern European countries, inverse associations with risk were found for blood levels of several carotenoids, whereas the association was strongest for -tocopherol in Southern European countries. The role of carotenoids and vitamins should be considered in subsequent investigations of the etiology of pancreatic cancer. (Less)
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keywords
pancreatic cancer, carotenoid, vitamin C, retinol, tocopherol
in
International Journal of Cancer
volume
136
issue
6
pages
665 - 676
publisher
John Wiley & Sons
external identifiers
  • wos:000347705200019
  • scopus:84961291892
ISSN
0020-7136
DOI
10.1002/ijc.29175
language
English
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yes
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5d1bb53a-4e29-409a-829e-9cb1266c1906 (old id 5186040)
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2015-04-01 07:34:45
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2016-07-01 04:03:44
@article{5d1bb53a-4e29-409a-829e-9cb1266c1906,
  abstract     = {Evidence of a protective effect of several antioxidants and other nutrients on pancreatic cancer risk is inconsistent. The aim of this study was to investigate the association for prediagnostic plasma levels of carotenoids, vitamin C, retinol and tocopherols with risk of pancreatic cancer in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). 446 incident exocrine pancreatic cancer cases were matched to 446 controls by age at blood collection, study center, sex, date and time of blood collection, fasting status and hormone use. Plasma carotenoids (- and -carotene, lycopene, -cryptoxanthin, canthaxanthin, zeaxanthin and lutein), - and -tocopherol and retinol were measured by reverse phase high-performance liquid chromatography and plasma vitamin C by a colorimetric assay. Incidence rate ratios (IRRs) with 95% confidence intervals (95%CIs) for pancreatic cancer risk were estimated using a conditional logistic regression analysis, adjusted for smoking status, smoking duration and intensity, waist circumference, cotinine levels and diabetes status. Inverse associations with pancreatic cancer risk were found for plasma -carotene (IRR highest vs. lowest quartile 0.52, 95%CI 0.31-0.88, p for trend=0.02), zeaxanthin (IRR highest vs. lowest quartile 0.53, 95%CI 0.30-0.94, p for trend=0.06) and -tocopherol (IRR highest vs. lowest quartile 0.62, 95%CI 0.39-0.99, p for trend=0.08. For - and -carotene, lutein, sum of carotenoids and -tocopherol, heterogeneity between geographical regions was observed. In conclusion, our results show that higher plasma concentrations of -carotene, zeaxanthin and -tocopherol may be inversely associated with risk of pancreatic cancer, but further studies are warranted. What's new? Fruits and vegetables may play a role in the prevention of pancreatic cancer, but associations between the antioxidants those foods contain and disease risk remain unclear. In this study, pancreatic cancer risk was inversely associated with increased prediagnostic plasma concentrations of the antioxidants -carotene, zeaxanthin, and -tocopherol. Geographic variations were also detected. In Northern European countries, inverse associations with risk were found for blood levels of several carotenoids, whereas the association was strongest for -tocopherol in Southern European countries. The role of carotenoids and vitamins should be considered in subsequent investigations of the etiology of pancreatic cancer.},
  author       = {Jeurnink, Suzanne M. and Ros, Martine M. and Leenders, Max and van Duijnhoven, Franzel J. B. and Siersema, Peter D. and Jansen, Eugene H. J. M. and van Gils, Carla H. and Bakker, Marije F. and Overvad, Kim and Roswall, Nina and Tjonneland, Anne and Boutron-Ruault, Marie-Christine and Racine, Antoine and Cadeau, Claire and Grote, Verena and Kaaks, Rudolf and Aleksandrova, Krasimira and Boeing, Heiner and Trichopoulou, Antonia and Benetou, Vasiliki and Valanou, Elisavet and Palli, Domenico and Krogh, Vittorio and Vineis, Paolo and Tumino, Rosario and Mattiello, Amalia and Weiderpass, Elisabete and Skeie, Guri and Huerta Castano, Jose Maria and Duell, Eric J. and Barricarte, Aurelio and Molina-Montes, Esther and Argueelles, Marcial and Dorronsoro, Mire and Johansen, Dorthe and Lindkvist, Bjorn and Sund, Malin and Crowe, Francesca L. and Khaw, Kay-Tee and Jenab, Mazda and Fedirko, Veronika and Riboli, E. and Bueno-de-Mesquita, H. B(as)},
  issn         = {0020-7136},
  keyword      = {pancreatic cancer,carotenoid,vitamin C,retinol,tocopherol},
  language     = {eng},
  number       = {6},
  pages        = {665--676},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Plasma carotenoids, vitamin C, retinol and tocopherols levels and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition: A nested case-control study Plasma micronutrients and pancreatic cancer risk},
  url          = {http://dx.doi.org/10.1002/ijc.29175},
  volume       = {136},
  year         = {2015},
}