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Reduced content of chloroatranol and atranol in oak moss absolute significantly reduces the elicitation potential of this fragrance material

Andersen, Flemming; Andersen, Kirsten H.; Bernois, Armand; Brault, Christophe; Bruze, Magnus LU ; Eudes, Herve; Gadras, Catherine; Signoret, Anne-Cecile J.; Mose, Kristian F. and Mueller, Boris P., et al. (2015) In Contact Dermatitis 72(2). p.75-83
Abstract
BackgroundOak moss absolute, an extract from the lichen Evernia prunastri, is a valued perfume ingredient but contains extreme allergens. ObjectivesTo compare the elicitation properties of two preparations of oak moss absolute: classic oak moss', the historically used preparation, and new oak moss', with reduced contents of the major allergens atranol and chloroatranol. Patients/materials/methodsThe two preparations were compared in randomized double-blinded repeated open application tests and serial dilution patch tests in 30 oak moss-sensitive volunteers and 30 non-allergic control subjects. ResultsIn both test models, new oak moss elicited significantly less allergic contact dermatitis in oak moss-sensitive subjects than classic oak... (More)
BackgroundOak moss absolute, an extract from the lichen Evernia prunastri, is a valued perfume ingredient but contains extreme allergens. ObjectivesTo compare the elicitation properties of two preparations of oak moss absolute: classic oak moss', the historically used preparation, and new oak moss', with reduced contents of the major allergens atranol and chloroatranol. Patients/materials/methodsThe two preparations were compared in randomized double-blinded repeated open application tests and serial dilution patch tests in 30 oak moss-sensitive volunteers and 30 non-allergic control subjects. ResultsIn both test models, new oak moss elicited significantly less allergic contact dermatitis in oak moss-sensitive subjects than classic oak moss. The control subjects did not react to either of the preparations. ConclusionsNew oak moss is still a fragrance allergen, but elicits less allergic contact dermatitis in previously oak moss-sensitized individuals, suggesting that new oak moss is less allergenic to non-sensitized individuals. (Less)
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publication status
published
subject
keywords
allergic contact dermatitis, fragrances, patch test, risk assessment
in
Contact Dermatitis
volume
72
issue
2
pages
75 - 83
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000348742500002
  • scopus:84921405663
ISSN
0105-1873
DOI
10.1111/cod.12312
language
English
LU publication?
yes
id
41084ca5-1f37-43a6-8e18-f3916b01c6af (old id 5187083)
date added to LUP
2015-04-01 07:34:16
date last changed
2017-11-05 03:20:19
@article{41084ca5-1f37-43a6-8e18-f3916b01c6af,
  abstract     = {BackgroundOak moss absolute, an extract from the lichen Evernia prunastri, is a valued perfume ingredient but contains extreme allergens. ObjectivesTo compare the elicitation properties of two preparations of oak moss absolute: classic oak moss', the historically used preparation, and new oak moss', with reduced contents of the major allergens atranol and chloroatranol. Patients/materials/methodsThe two preparations were compared in randomized double-blinded repeated open application tests and serial dilution patch tests in 30 oak moss-sensitive volunteers and 30 non-allergic control subjects. ResultsIn both test models, new oak moss elicited significantly less allergic contact dermatitis in oak moss-sensitive subjects than classic oak moss. The control subjects did not react to either of the preparations. ConclusionsNew oak moss is still a fragrance allergen, but elicits less allergic contact dermatitis in previously oak moss-sensitized individuals, suggesting that new oak moss is less allergenic to non-sensitized individuals.},
  author       = {Andersen, Flemming and Andersen, Kirsten H. and Bernois, Armand and Brault, Christophe and Bruze, Magnus and Eudes, Herve and Gadras, Catherine and Signoret, Anne-Cecile J. and Mose, Kristian F. and Mueller, Boris P. and Toulemonde, Bernard and Andersen, Klaus Ejner},
  issn         = {0105-1873},
  keyword      = {allergic contact dermatitis,fragrances,patch test,risk assessment},
  language     = {eng},
  number       = {2},
  pages        = {75--83},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Reduced content of chloroatranol and atranol in oak moss absolute significantly reduces the elicitation potential of this fragrance material},
  url          = {http://dx.doi.org/10.1111/cod.12312},
  volume       = {72},
  year         = {2015},
}