Advanced

Treatment patterns with topicals, traditional systemics and biologics in psoriasis - a Swedish database analysis

Svedbom, A.; Dalen, J.; Mamolo, C.; Cappelleri, J. C.; Petersson, Ingemar LU and Stahle, M. (2015) In Journal of the European Academy of Dermatology and Venereology 29(2). p.215-223
Abstract
BackgroundLittle data exist on real-world treatment patterns in psoriasis, especially from European settings. ObjectiveTo estimate, for topicals, systemics and biologics, the time to non-persistency, switching, augmentation and insufficient treatment result (only for biologics), as well as to estimate the time to restart, in patients treated with each treatment class in Sweden based on registry data. MethodsThis database analysis utilized data from patients with psoriasis from several Swedish administrative registers. Patients were identified through combinations of diagnoses from two regional registers and filled prescriptions for relevant treatments from the Swedish Prescribed Drug Register. Kaplan-Meier time-to-event (survival')... (More)
BackgroundLittle data exist on real-world treatment patterns in psoriasis, especially from European settings. ObjectiveTo estimate, for topicals, systemics and biologics, the time to non-persistency, switching, augmentation and insufficient treatment result (only for biologics), as well as to estimate the time to restart, in patients treated with each treatment class in Sweden based on registry data. MethodsThis database analysis utilized data from patients with psoriasis from several Swedish administrative registers. Patients were identified through combinations of diagnoses from two regional registers and filled prescriptions for relevant treatments from the Swedish Prescribed Drug Register. Kaplan-Meier time-to-event (survival') functions were estimated with relevant treatment events as failure and the proportions of patients having experienced an event at specific time-points were derived from the failure rates. ResultsFor topicals, systemics and biologics the number of indexed treatment episodes were 25396, 2963, and 628 respectively. One year after treatment initiation, the proportion of patients who were classed as non-persistent with topicals, systemics and biologics were estimated at 88.3%, 47.9% and 43.2% respectively. Among patients who remained persistent, within 1year of treatment start the proportions of treatment episodes in which patients were augmented were estimated at 56.0% for topicals, 45.3% for systemics and 58.9% for biologics. In addition, within 1year of non-persistence, 49.0% of topicals, 60.8% of systemics and 80.2% of biologics treatment episodes were re-initiated, with 35.4-52.5% re-initiated on the non-persistent treatment depending on treatment class. In addition, among patients on biologics, 29.2% of treatment episodes had an insufficient treatment result within 1year of treatment start. ConclusionPersistency to psoriasis treatments may be sub-optimal and patients who remain persistent relatively frequently receive augmentation therapy or switch to another therapy. Therefore, current treatment options in psoriasis may be insufficient. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the European Academy of Dermatology and Venereology
volume
29
issue
2
pages
215 - 223
publisher
Elsevier
external identifiers
  • wos:000348717700004
  • scopus:84921507225
ISSN
1468-3083
DOI
10.1111/jdv.12494
language
English
LU publication?
yes
id
fa3f32d1-cc0d-49de-8af6-289f8e7daa08 (old id 5187265)
date added to LUP
2015-04-01 07:31:24
date last changed
2017-08-06 03:10:36
@article{fa3f32d1-cc0d-49de-8af6-289f8e7daa08,
  abstract     = {BackgroundLittle data exist on real-world treatment patterns in psoriasis, especially from European settings. ObjectiveTo estimate, for topicals, systemics and biologics, the time to non-persistency, switching, augmentation and insufficient treatment result (only for biologics), as well as to estimate the time to restart, in patients treated with each treatment class in Sweden based on registry data. MethodsThis database analysis utilized data from patients with psoriasis from several Swedish administrative registers. Patients were identified through combinations of diagnoses from two regional registers and filled prescriptions for relevant treatments from the Swedish Prescribed Drug Register. Kaplan-Meier time-to-event (survival') functions were estimated with relevant treatment events as failure and the proportions of patients having experienced an event at specific time-points were derived from the failure rates. ResultsFor topicals, systemics and biologics the number of indexed treatment episodes were 25396, 2963, and 628 respectively. One year after treatment initiation, the proportion of patients who were classed as non-persistent with topicals, systemics and biologics were estimated at 88.3%, 47.9% and 43.2% respectively. Among patients who remained persistent, within 1year of treatment start the proportions of treatment episodes in which patients were augmented were estimated at 56.0% for topicals, 45.3% for systemics and 58.9% for biologics. In addition, within 1year of non-persistence, 49.0% of topicals, 60.8% of systemics and 80.2% of biologics treatment episodes were re-initiated, with 35.4-52.5% re-initiated on the non-persistent treatment depending on treatment class. In addition, among patients on biologics, 29.2% of treatment episodes had an insufficient treatment result within 1year of treatment start. ConclusionPersistency to psoriasis treatments may be sub-optimal and patients who remain persistent relatively frequently receive augmentation therapy or switch to another therapy. Therefore, current treatment options in psoriasis may be insufficient.},
  author       = {Svedbom, A. and Dalen, J. and Mamolo, C. and Cappelleri, J. C. and Petersson, Ingemar and Stahle, M.},
  issn         = {1468-3083},
  language     = {eng},
  number       = {2},
  pages        = {215--223},
  publisher    = {Elsevier},
  series       = {Journal of the European Academy of Dermatology and Venereology},
  title        = {Treatment patterns with topicals, traditional systemics and biologics in psoriasis - a Swedish database analysis},
  url          = {http://dx.doi.org/10.1111/jdv.12494},
  volume       = {29},
  year         = {2015},
}