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Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort

Ose, J.; Fortner, R. T.; Schock, H.; Peeters, P. H.; Onland-Moret, N. C.; Bueno-de-Mesquita, H. B.; Weiderpass, E.; Gram, I. T.; Overvad, K. and Tjonneland, A., et al. (2015) In British Journal of Cancer 112(1). p.162-166
Abstract
Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n = 565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not... (More)
Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n = 565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk. (Less)
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published
subject
keywords
IGF-I, ovarian cancer, histological subtypes, carcinogenesis, type, I/type II, dualistic pathway
in
British Journal of Cancer
volume
112
issue
1
pages
162 - 166
publisher
Nature Publishing Group
external identifiers
  • wos:000348280900024
  • scopus:84920661769
ISSN
1532-1827
DOI
10.1038/bjc.2014.566
language
English
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yes
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18e5ccfe-8839-4eb2-9f1a-c70dc2f09f1f (old id 5194526)
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2015-04-01 07:34:56
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2017-05-21 03:19:53
@article{18e5ccfe-8839-4eb2-9f1a-c70dc2f09f1f,
  abstract     = {Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n = 565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.},
  author       = {Ose, J. and Fortner, R. T. and Schock, H. and Peeters, P. H. and Onland-Moret, N. C. and Bueno-de-Mesquita, H. B. and Weiderpass, E. and Gram, I. T. and Overvad, K. and Tjonneland, A. and Dossus, L. and Fournier, A. and Baglietto, L. and Trichopoulou, A. and Benetou, V. and Trichopoulos, D. and Boeing, H. and Masala, G. and Krogh, V. and Matiello, A. and Tumino, R. and Popovic, M. and Obon-Santacana, M. and Larranaga, N. and Ardanaz, E. and Sanchez, M-J and Menendez, V. and Chirlaque, M-D and Travis, R. C. and Khaw, K-T and Brändstedt, Jenny and Idahl, A. and Lundin, E. and Rinaldi, S. and Kuhn, E. and Romieu, I. and Gunter, M. J. and Merritt, M. A. and Riboli, E. and Kaaks, R.},
  issn         = {1532-1827},
  keyword      = {IGF-I,ovarian cancer,histological subtypes,carcinogenesis,type,I/type II,dualistic pathway},
  language     = {eng},
  number       = {1},
  pages        = {162--166},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort},
  url          = {http://dx.doi.org/10.1038/bjc.2014.566},
  volume       = {112},
  year         = {2015},
}