Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase 4 activity in obese patients with type 2 diabetes.
(2011) In Diabetes, Obesity and Metabolism 13(4). p.378-381- Abstract
- The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass surgery (GBP) is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10 kg equivalent weight loss by GBP (n=16) or by caloric restriction (CR, n=14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p=0.01), but not after CR. The increased peak GLP-1 and GIP response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a... (More)
- The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass surgery (GBP) is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10 kg equivalent weight loss by GBP (n=16) or by caloric restriction (CR, n=14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p=0.01), but not after CR. The increased peak GLP-1 and GIP response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretins concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1777738
- author
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- dipeptidyl peptidase inhibitor, gastric bypass, weight loss, GLP-1
- in
- Diabetes, Obesity and Metabolism
- volume
- 13
- issue
- 4
- pages
- 378 - 381
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000287663500010
- pmid:21210936
- scopus:79951868952
- ISSN
- 1462-8902
- DOI
- 10.1111/j.1463-1326.2011.01358.x
- language
- English
- LU publication?
- yes
- id
- 524c4190-f041-4ecc-ae88-a1eb9fedd4f5 (old id 1777738)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21210936?dopt=Abstract
- date added to LUP
- 2016-04-01 09:54:17
- date last changed
- 2024-01-06 02:39:57
@article{524c4190-f041-4ecc-ae88-a1eb9fedd4f5, abstract = {{The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass surgery (GBP) is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10 kg equivalent weight loss by GBP (n=16) or by caloric restriction (CR, n=14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p=0.01), but not after CR. The increased peak GLP-1 and GIP response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretins concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined.}}, author = {{Alam, M and Van der Schueren, B J and Ahrén, Bo and Wang, G C and Swerdlow, N J and Arias, S and Bose, M and Gorroochurn, P and Teixeira, J and McGinty, J and Laferrère, B}}, issn = {{1462-8902}}, keywords = {{dipeptidyl peptidase inhibitor; gastric bypass; weight loss; GLP-1}}, language = {{eng}}, number = {{4}}, pages = {{378--381}}, publisher = {{Wiley-Blackwell}}, series = {{Diabetes, Obesity and Metabolism}}, title = {{Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase 4 activity in obese patients with type 2 diabetes.}}, url = {{http://dx.doi.org/10.1111/j.1463-1326.2011.01358.x}}, doi = {{10.1111/j.1463-1326.2011.01358.x}}, volume = {{13}}, year = {{2011}}, }