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PATIENT DOSIMETRY IN NUCLEAR MEDICINE.

Mattsson, Sören LU (2015) In Radiation Protection Dosimetry 165(1-4). p.416-423
Abstract
In diagnostic nuclear medicine, the biokinetics of the radiopharmaceutical (actually of the radionuclide) is determined for a number of representative patients. At therapy, it is essential to determine the patient's individual biokinetics of the radiopharmaceutical in order to calculate the absorbed doses to critical normal organs/tissues and to the target volume(s) with high accuracy. For the diagnostic situations, there is still a lack of quantitative determinations of the organ/tissue contents of radiopharmaceuticals and their variation with time. Planar gamma camera imaging using the conjugate view technique combined with a limited number of SPECT/CT images is the main method for such studies. In a similar way, PET/CT is used for 3D... (More)
In diagnostic nuclear medicine, the biokinetics of the radiopharmaceutical (actually of the radionuclide) is determined for a number of representative patients. At therapy, it is essential to determine the patient's individual biokinetics of the radiopharmaceutical in order to calculate the absorbed doses to critical normal organs/tissues and to the target volume(s) with high accuracy. For the diagnostic situations, there is still a lack of quantitative determinations of the organ/tissue contents of radiopharmaceuticals and their variation with time. Planar gamma camera imaging using the conjugate view technique combined with a limited number of SPECT/CT images is the main method for such studies. In a similar way, PET/CT is used for 3D image-based internal dosimetry for PET substances. The transition from stylised reference phantoms to voxel phantoms will lead to improved dose estimates for diagnostic procedures. Examples of dose coefficients and effective doses for diagnostic substances are given. For the therapeutic situation, a pre-therapeutic low activity administration is used for quantitative measurements of organ/tissue distribution data by a gamma camera or a SPECT- or PET-unit. Together with CT and/or MR images this will be the base for individual dose calculations using Monte Carlo technique. Treatments based on administered activity should only be used if biological variations between patients are small or if a pre-therapeutic activity administration is impossible. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Radiation Protection Dosimetry
volume
165
issue
1-4
pages
416 - 423
publisher
Nuclear Technology Publishing
external identifiers
  • pmid:25821210
  • wos:000358449300091
  • scopus:84939483269
ISSN
1742-3406
DOI
10.1093/rpd/ncv061
language
English
LU publication?
yes
id
ba04ffb0-8705-4cf8-ba9d-5001f7350c29 (old id 5257318)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25821210?dopt=Abstract
date added to LUP
2015-04-04 16:28:11
date last changed
2017-01-01 03:36:45
@article{ba04ffb0-8705-4cf8-ba9d-5001f7350c29,
  abstract     = {In diagnostic nuclear medicine, the biokinetics of the radiopharmaceutical (actually of the radionuclide) is determined for a number of representative patients. At therapy, it is essential to determine the patient's individual biokinetics of the radiopharmaceutical in order to calculate the absorbed doses to critical normal organs/tissues and to the target volume(s) with high accuracy. For the diagnostic situations, there is still a lack of quantitative determinations of the organ/tissue contents of radiopharmaceuticals and their variation with time. Planar gamma camera imaging using the conjugate view technique combined with a limited number of SPECT/CT images is the main method for such studies. In a similar way, PET/CT is used for 3D image-based internal dosimetry for PET substances. The transition from stylised reference phantoms to voxel phantoms will lead to improved dose estimates for diagnostic procedures. Examples of dose coefficients and effective doses for diagnostic substances are given. For the therapeutic situation, a pre-therapeutic low activity administration is used for quantitative measurements of organ/tissue distribution data by a gamma camera or a SPECT- or PET-unit. Together with CT and/or MR images this will be the base for individual dose calculations using Monte Carlo technique. Treatments based on administered activity should only be used if biological variations between patients are small or if a pre-therapeutic activity administration is impossible.},
  author       = {Mattsson, Sören},
  issn         = {1742-3406},
  language     = {eng},
  number       = {1-4},
  pages        = {416--423},
  publisher    = {Nuclear Technology Publishing},
  series       = {Radiation Protection Dosimetry},
  title        = {PATIENT DOSIMETRY IN NUCLEAR MEDICINE.},
  url          = {http://dx.doi.org/10.1093/rpd/ncv061},
  volume       = {165},
  year         = {2015},
}