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Cyclin A1 regulates the interactions between mouse hematopoietic stem and progenitor cells and their niches.

Miftakhova, Regina LU ; Hedblom, Andreas LU ; Batkiewicz, Leah; Anagnosaki, Lola; Zhang, Yuan LU ; Sjölander, Anita LU ; Gjörloff Wingren, Anette LU ; Wolgemuth, Debra J and Persson, Jenny L LU (2015) In Cell Cycle 14(12). p.1948-1960
Abstract
It remains poorly understood how the hematopoietic stem/progenitor cells (HSPC) are attracted to their niches and the functional consequences of such interaction. In the present study, we show that the cell cycle regulator cyclin A1 in association with vascular endothelial growth factor receptor 1 (VEGFR1), is required for HSPC and their niches to maintain their function and proper interaction. In the absence of cyclin A1, the HSPC in the BM are increased in their frequency and display an increased migratory and homing ability. Concomitantly, the ability of the endosteal and central BM niche zones to attract and home the wild-type HSPC is significantly reduced in cyclin A1-null mice as compared to the wild-type controls. The impaired... (More)
It remains poorly understood how the hematopoietic stem/progenitor cells (HSPC) are attracted to their niches and the functional consequences of such interaction. In the present study, we show that the cell cycle regulator cyclin A1 in association with vascular endothelial growth factor receptor 1 (VEGFR1), is required for HSPC and their niches to maintain their function and proper interaction. In the absence of cyclin A1, the HSPC in the BM are increased in their frequency and display an increased migratory and homing ability. Concomitantly, the ability of the endosteal and central BM niche zones to attract and home the wild-type HSPC is significantly reduced in cyclin A1-null mice as compared to the wild-type controls. The impaired proliferation and homing of HSPC in the BM of cyclin A1-null mice are attributed to the increased density of microvessels in the endosteal and central BM niche zones, which is associated with the increased VEGFR1 expression. Thus, modulation of cyclin A1 and VEGFR1 in HSPC and their niches may provide new insights into therapeutic approaches. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cell Cycle
volume
14
issue
12
pages
1948 - 1960
publisher
Landes Bioscience
external identifiers
  • pmid:25785996
  • wos:000356374600023
  • scopus:84943742032
ISSN
1551-4005
DOI
10.1080/15384101.2015.1026513
language
English
LU publication?
yes
id
d80c7a35-c706-4a5b-82d1-c78566410ebe (old id 5258220)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25785996?dopt=Abstract
date added to LUP
2015-04-05 18:49:25
date last changed
2017-01-01 04:01:29
@article{d80c7a35-c706-4a5b-82d1-c78566410ebe,
  abstract     = {It remains poorly understood how the hematopoietic stem/progenitor cells (HSPC) are attracted to their niches and the functional consequences of such interaction. In the present study, we show that the cell cycle regulator cyclin A1 in association with vascular endothelial growth factor receptor 1 (VEGFR1), is required for HSPC and their niches to maintain their function and proper interaction. In the absence of cyclin A1, the HSPC in the BM are increased in their frequency and display an increased migratory and homing ability. Concomitantly, the ability of the endosteal and central BM niche zones to attract and home the wild-type HSPC is significantly reduced in cyclin A1-null mice as compared to the wild-type controls. The impaired proliferation and homing of HSPC in the BM of cyclin A1-null mice are attributed to the increased density of microvessels in the endosteal and central BM niche zones, which is associated with the increased VEGFR1 expression. Thus, modulation of cyclin A1 and VEGFR1 in HSPC and their niches may provide new insights into therapeutic approaches.},
  author       = {Miftakhova, Regina and Hedblom, Andreas and Batkiewicz, Leah and Anagnosaki, Lola and Zhang, Yuan and Sjölander, Anita and Gjörloff Wingren, Anette and Wolgemuth, Debra J and Persson, Jenny L},
  issn         = {1551-4005},
  language     = {eng},
  number       = {12},
  pages        = {1948--1960},
  publisher    = {Landes Bioscience},
  series       = {Cell Cycle},
  title        = {Cyclin A1 regulates the interactions between mouse hematopoietic stem and progenitor cells and their niches.},
  url          = {http://dx.doi.org/10.1080/15384101.2015.1026513},
  volume       = {14},
  year         = {2015},
}