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RIFINs are adhesins implicated in severe Plasmodium falciparum malaria.

Goel, Suchi; Palmkvist, Mia; Moll, Kirsten; Joannin, Nicolas; Lara, Patricia; R Akhouri, Reetesh; Moradi, Nasim; Öjemalm, Karin; Westman, Mattias and Angeletti, Davide, et al. (2015) In Nature Medicine 21(4). p.314-317
Abstract
Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), where they bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.
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Contribution to journal
publication status
published
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Nature Medicine
volume
21
issue
4
pages
314 - 317
publisher
Nature Publishing Group
external identifiers
  • pmid:25751816
  • wos:000352493600012
  • scopus:84926684537
ISSN
1546-170X
DOI
10.1038/nm.3812
language
English
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yes
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63ededd1-b81d-44d4-8675-d9e2109c1370 (old id 5265001)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25751816?dopt=Abstract
date added to LUP
2015-04-02 15:46:56
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2017-10-09 09:37:02
@article{63ededd1-b81d-44d4-8675-d9e2109c1370,
  abstract     = {Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), where they bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.},
  author       = {Goel, Suchi and Palmkvist, Mia and Moll, Kirsten and Joannin, Nicolas and Lara, Patricia and R Akhouri, Reetesh and Moradi, Nasim and Öjemalm, Karin and Westman, Mattias and Angeletti, Davide and Kjellin, Hanna and Lehtiö, Janne and Blixt, Ola and Ideström, Lars and Gahmberg, Carl G and Storry, Jill and Hult, Annika and Olsson, Martin L and von Heijne, Gunnar and Nilsson, IngMarie and Wahlgren, Mats},
  issn         = {1546-170X},
  language     = {eng},
  number       = {4},
  pages        = {314--317},
  publisher    = {Nature Publishing Group},
  series       = {Nature Medicine},
  title        = {RIFINs are adhesins implicated in severe Plasmodium falciparum malaria.},
  url          = {http://dx.doi.org/10.1038/nm.3812},
  volume       = {21},
  year         = {2015},
}