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Increased aldehyde-modification of collagen type IV in symptomatic plaques - A possible cause of endothelial dysfunction.

Dunér, Pontus LU ; Goncalves, Isabel LU ; Grufman, Helena LU ; Edsfeldt, Andreas LU ; To, Fong LU ; Nitulescu, Mihaela LU ; Nilsson, Jan LU and Bengtsson, Eva LU (2015) In Atherosclerosis 240(1). p.26-32
Abstract
Subendothelial LDL-adhesion and its subsequent oxidation are considered as key events in the development of atherosclerotic lesions. During oxidation of LDL, reactive aldehydes such as malondialdehyde (MDA) are formed, which modify apolipoprotein B100. However, the possibility that these reactive aldehydes could leak out of the LDL-particle and modify surrounding extracellular matrix proteins has been largely unexplored. We have investigated if aldehyde-modification of collagen type IV, one of the major basement membrane components, in plaques is associated with cardiovascular events.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Atherosclerosis
volume
240
issue
1
pages
26 - 32
publisher
Elsevier
external identifiers
  • pmid:25746374
  • wos:000352703400006
  • scopus:84923924139
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2015.02.043
language
English
LU publication?
yes
id
49827797-6a2c-4eb2-8774-7271aca7edc3 (old id 5265128)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25746374?dopt=Abstract
date added to LUP
2015-04-02 15:03:35
date last changed
2017-03-26 03:10:50
@article{49827797-6a2c-4eb2-8774-7271aca7edc3,
  abstract     = {Subendothelial LDL-adhesion and its subsequent oxidation are considered as key events in the development of atherosclerotic lesions. During oxidation of LDL, reactive aldehydes such as malondialdehyde (MDA) are formed, which modify apolipoprotein B100. However, the possibility that these reactive aldehydes could leak out of the LDL-particle and modify surrounding extracellular matrix proteins has been largely unexplored. We have investigated if aldehyde-modification of collagen type IV, one of the major basement membrane components, in plaques is associated with cardiovascular events.},
  author       = {Dunér, Pontus and Goncalves, Isabel and Grufman, Helena and Edsfeldt, Andreas and To, Fong and Nitulescu, Mihaela and Nilsson, Jan and Bengtsson, Eva},
  issn         = {1879-1484},
  language     = {eng},
  number       = {1},
  pages        = {26--32},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {Increased aldehyde-modification of collagen type IV in symptomatic plaques - A possible cause of endothelial dysfunction.},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2015.02.043},
  volume       = {240},
  year         = {2015},
}