Increased aldehyde-modification of collagen type IV in symptomatic plaques - A possible cause of endothelial dysfunction.
Dunér, Pontus LU ; Goncalves, Isabel LU
; Grufman, Helena
LU
; Edsfeldt, Andreas
LU
; To, Fong
LU
; Nitulescu, Mihaela
LU
; Nilsson, Jan
LU
and Bengtsson, Eva
LU
(2015)
In Atherosclerosis
240(1).
p.26-32
- Abstract
- Subendothelial LDL-adhesion and its subsequent oxidation are considered as key events in the development of atherosclerotic lesions. During oxidation of LDL, reactive aldehydes such as malondialdehyde (MDA) are formed, which modify apolipoprotein B100. However, the possibility that these reactive aldehydes could leak out of the LDL-particle and modify surrounding extracellular matrix proteins has been largely unexplored. We have investigated if aldehyde-modification of collagen type IV, one of the major basement membrane components, in plaques is associated with cardiovascular events.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5265128
- author
- Dunér, Pontus
LU
; Goncalves, Isabel
LU
; Grufman, Helena
LU
; Edsfeldt, Andreas
LU
; To, Fong
LU
; Nitulescu, Mihaela
LU
; Nilsson, Jan
LU
and Bengtsson, Eva
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Atherosclerosis
- volume
- 240
- issue
- 1
- pages
- 26 - 32
- publisher
- Elsevier
- external identifiers
-
- pmid:25746374
- wos:000352703400006
- scopus:84923924139
- pmid:25746374
- ISSN
- 1879-1484
- DOI
- 10.1016/j.atherosclerosis.2015.02.043
- language
- English
- LU publication?
- yes
- id
- 49827797-6a2c-4eb2-8774-7271aca7edc3 (old id 5265128)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25746374?dopt=Abstract
- date added to LUP
- 2016-04-01 10:24:26
- date last changed
- 2022-03-04 19:13:58
@article{49827797-6a2c-4eb2-8774-7271aca7edc3,
abstract = {{Subendothelial LDL-adhesion and its subsequent oxidation are considered as key events in the development of atherosclerotic lesions. During oxidation of LDL, reactive aldehydes such as malondialdehyde (MDA) are formed, which modify apolipoprotein B100. However, the possibility that these reactive aldehydes could leak out of the LDL-particle and modify surrounding extracellular matrix proteins has been largely unexplored. We have investigated if aldehyde-modification of collagen type IV, one of the major basement membrane components, in plaques is associated with cardiovascular events.}},
author = {{Dunér, Pontus and Goncalves, Isabel and Grufman, Helena and Edsfeldt, Andreas and To, Fong and Nitulescu, Mihaela and Nilsson, Jan and Bengtsson, Eva}},
issn = {{1879-1484}},
language = {{eng}},
number = {{1}},
pages = {{26--32}},
publisher = {{Elsevier}},
series = {{Atherosclerosis}},
title = {{Increased aldehyde-modification of collagen type IV in symptomatic plaques - A possible cause of endothelial dysfunction.}},
url = {{https://lup.lub.lu.se/search/files/1819080/8056711.pdf}},
doi = {{10.1016/j.atherosclerosis.2015.02.043}},
volume = {{240}},
year = {{2015}},
}