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Profound Increase in Longitudinal Displacements of the Porcine Carotid Artery Wall Can Take Place Independently of Wall Shear Stress: A Continuation Report.

Rydén Ahlgren, Åsa LU ; Steen, Stig LU ; Segstedt, Simon; Erlöv, Tobias; Lindström, Kjell; Sjöberg, Trygve LU ; Persson, Hans W; Ricci, Stefano; Tortoli, Piero and Cinthio, Magnus (2015) In Ultrasound in Medicine and Biology 41(5). p.1342-1353
Abstract
The mechanisms underlying longitudinal displacements of the arterial wall, that is, displacements of the wall layers along the artery, and the resulting intramural shear strain remain largely unknown. We have already found that these displacements undergo profound changes in response to catecholamines. Wall shear stress, closely related to wall shear rate, represents the viscous drag exerted on the vessel wall by flowing blood. The aim of the work described here was to study possible relations between the wall shear rate and the longitudinal displacements. We investigated the carotid arteries of five anesthetized pigs in different hemodynamic situations using in-house developed non-invasive ultrasound techniques. The study protocol... (More)
The mechanisms underlying longitudinal displacements of the arterial wall, that is, displacements of the wall layers along the artery, and the resulting intramural shear strain remain largely unknown. We have already found that these displacements undergo profound changes in response to catecholamines. Wall shear stress, closely related to wall shear rate, represents the viscous drag exerted on the vessel wall by flowing blood. The aim of the work described here was to study possible relations between the wall shear rate and the longitudinal displacements. We investigated the carotid arteries of five anesthetized pigs in different hemodynamic situations using in-house developed non-invasive ultrasound techniques. The study protocol included administration of epinephrine, norepinephrine and β-blockade (metoprolol). No significant correlation between longitudinal displacement of the intima-media complex and wall shear rate was found. This result suggests that one or multiple pulsatile forces other than wall shear stress are also working along arteries, strongly influencing arterial wall behavior. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Ultrasound in Medicine and Biology
volume
41
issue
5
pages
1342 - 1353
publisher
Elsevier
external identifiers
  • pmid:25726134
  • wos:000352803100021
  • scopus:84927571157
ISSN
0301-5629
DOI
10.1016/j.ultrasmedbio.2015.01.005
language
English
LU publication?
yes
id
c4bb9f5a-b135-4892-8a35-40158c356bed (old id 5265697)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25726134?dopt=Abstract
date added to LUP
2015-04-01 17:22:23
date last changed
2017-07-30 03:21:37
@article{c4bb9f5a-b135-4892-8a35-40158c356bed,
  abstract     = {The mechanisms underlying longitudinal displacements of the arterial wall, that is, displacements of the wall layers along the artery, and the resulting intramural shear strain remain largely unknown. We have already found that these displacements undergo profound changes in response to catecholamines. Wall shear stress, closely related to wall shear rate, represents the viscous drag exerted on the vessel wall by flowing blood. The aim of the work described here was to study possible relations between the wall shear rate and the longitudinal displacements. We investigated the carotid arteries of five anesthetized pigs in different hemodynamic situations using in-house developed non-invasive ultrasound techniques. The study protocol included administration of epinephrine, norepinephrine and β-blockade (metoprolol). No significant correlation between longitudinal displacement of the intima-media complex and wall shear rate was found. This result suggests that one or multiple pulsatile forces other than wall shear stress are also working along arteries, strongly influencing arterial wall behavior.},
  author       = {Rydén Ahlgren, Åsa and Steen, Stig and Segstedt, Simon and Erlöv, Tobias and Lindström, Kjell and Sjöberg, Trygve and Persson, Hans W and Ricci, Stefano and Tortoli, Piero and Cinthio, Magnus},
  issn         = {0301-5629},
  language     = {eng},
  number       = {5},
  pages        = {1342--1353},
  publisher    = {Elsevier},
  series       = {Ultrasound in Medicine and Biology},
  title        = {Profound Increase in Longitudinal Displacements of the Porcine Carotid Artery Wall Can Take Place Independently of Wall Shear Stress: A Continuation Report.},
  url          = {http://dx.doi.org/10.1016/j.ultrasmedbio.2015.01.005},
  volume       = {41},
  year         = {2015},
}