Is the fatty raised lesion a pre-atheromatous lesion? - A preliminary study
(1998) In Nihon University Journal of Medicine 40(4). p.225-233- Abstract
Traditionally, atherosclerosis has been evaluated macroscopically from the presence of fatty streaks (FS), fibrous plaques (FBP), and complicated lesions (CL). In this preliminary study, employing aortas from autopsied middle-aged or older persons we investigated the fatty raised lesion (FRL) to elucidate its significance and histological features. The FRL is determined macroscopically from its distinctive intimal elevation with a yellowish surface, so displaying mixed characteristics of the FS and the FBP. The FRL was identified macroscopically in 50% of 10 cases in the thoracic part of the aorta, and in 30% of the cases, in the abdominal part. When present, it occupied 6.4% and 5% of the intimal area in the thoracic and abdominal... (More)
Traditionally, atherosclerosis has been evaluated macroscopically from the presence of fatty streaks (FS), fibrous plaques (FBP), and complicated lesions (CL). In this preliminary study, employing aortas from autopsied middle-aged or older persons we investigated the fatty raised lesion (FRL) to elucidate its significance and histological features. The FRL is determined macroscopically from its distinctive intimal elevation with a yellowish surface, so displaying mixed characteristics of the FS and the FBP. The FRL was identified macroscopically in 50% of 10 cases in the thoracic part of the aorta, and in 30% of the cases, in the abdominal part. When present, it occupied 6.4% and 5% of the intimal area in the thoracic and abdominal parts, respectively. These data were comparable to those of other lesions. Microscopically, the FRL exhibited different histological types, depending on the presence of a necrotic core and the degree of fibrous tissue development in the cap region. One predominant type had a clearly recognizable necrotic core, similar to the FBP, and an active fatty cap region, resembling that of fatty plaque. The presence of FRLs may be an important characteristic to be examined during the progress of atherosclerosis.
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- author
- Frigyesi, Attila LU ; Kusumi, Yoshiaki ; Niihashi, Mari and Sakurai, Isamu
- organization
- publishing date
- 1998-08-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Atherosclerosis, Fatty plaque, Fibrous plaque, Intermediate plaque
- in
- Nihon University Journal of Medicine
- volume
- 40
- issue
- 4
- pages
- 9 pages
- publisher
- Nihon University
- external identifiers
-
- scopus:0348201509
- ISSN
- 0546-0352
- language
- English
- LU publication?
- yes
- id
- 52812993-16c0-46a4-b146-b3944b7f0980
- date added to LUP
- 2019-06-14 22:38:57
- date last changed
- 2022-03-25 20:26:47
@article{52812993-16c0-46a4-b146-b3944b7f0980,
abstract = {{<p>Traditionally, atherosclerosis has been evaluated macroscopically from the presence of fatty streaks (FS), fibrous plaques (FBP), and complicated lesions (CL). In this preliminary study, employing aortas from autopsied middle-aged or older persons we investigated the fatty raised lesion (FRL) to elucidate its significance and histological features. The FRL is determined macroscopically from its distinctive intimal elevation with a yellowish surface, so displaying mixed characteristics of the FS and the FBP. The FRL was identified macroscopically in 50% of 10 cases in the thoracic part of the aorta, and in 30% of the cases, in the abdominal part. When present, it occupied 6.4% and 5% of the intimal area in the thoracic and abdominal parts, respectively. These data were comparable to those of other lesions. Microscopically, the FRL exhibited different histological types, depending on the presence of a necrotic core and the degree of fibrous tissue development in the cap region. One predominant type had a clearly recognizable necrotic core, similar to the FBP, and an active fatty cap region, resembling that of fatty plaque. The presence of FRLs may be an important characteristic to be examined during the progress of atherosclerosis.</p>}},
author = {{Frigyesi, Attila and Kusumi, Yoshiaki and Niihashi, Mari and Sakurai, Isamu}},
issn = {{0546-0352}},
keywords = {{Atherosclerosis; Fatty plaque; Fibrous plaque; Intermediate plaque}},
language = {{eng}},
month = {{08}},
number = {{4}},
pages = {{225--233}},
publisher = {{Nihon University}},
series = {{Nihon University Journal of Medicine}},
title = {{Is the fatty raised lesion a pre-atheromatous lesion? - A preliminary study}},
volume = {{40}},
year = {{1998}},
}