Advanced

Transmission Near-Infrared (NIR) and Photon Time-of-Flight (PTOF) Spectroscopy in a Comparative Analysis of Pharmaceuticals

Kamran, Faisal; Abildgaard, Otto H. A.; Sparen, Anders; Svensson, Olof; Johansson, Jonas; Andersson-Engels, Stefan LU ; Andersen, Peter E. and Khoptyar, Dmitry LU (2015) In Applied Spectroscopy 69(3). p.389-397
Abstract
We present a comprehensive study of the application of photon time-of-flight spectroscopy (PTOFS) in the wavelength range 1050 1350 nm as a spectroscopic technique for the evaluation of the chemical composition and structural properties of pharmaceutical tablets. PTOFS is compared to transmission near-infrared spectroscopy (NIRS). In contrast to transmission NIRS, PTOFS is capable of directly and independently determining the absorption and reduced scattering coefficients of the medium. Chemometric models were built on the evaluated absorption spectra for predicting tablet drug concentration. Results are compared to corresponding predictions built on transmission NIRS measurements. The predictive ability of PTOFS and transmission NIRS is... (More)
We present a comprehensive study of the application of photon time-of-flight spectroscopy (PTOFS) in the wavelength range 1050 1350 nm as a spectroscopic technique for the evaluation of the chemical composition and structural properties of pharmaceutical tablets. PTOFS is compared to transmission near-infrared spectroscopy (NIRS). In contrast to transmission NIRS, PTOFS is capable of directly and independently determining the absorption and reduced scattering coefficients of the medium. Chemometric models were built on the evaluated absorption spectra for predicting tablet drug concentration. Results are compared to corresponding predictions built on transmission NIRS measurements. The predictive ability of PTOFS and transmission NIRS is comparable when models are based on uniformly distributed tablet sets. For non-uniform distribution of tablets based on particle sizes, the prediction ability of PTOFS is better than that of transmission NIRS. Analysis of reduced scattering spectra shows that PTOFS is able to characterize tablet microstructure and manufacturing process parameters. In contrast to the chemometric pseudovariables provided by transmission NIRS, PTOFS provides physically meaningful quantities such as scattering strength and slope of particle size. The ability of PTOFS to quantify the reduced scattering spectra, together with its robustness in predicting drug content, makes it suitable for such evaluations in the pharmaceutical industry. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
scattering, Multiple, Turbid media, Spectroscopy, Scattering measurements, condensed matter
in
Applied Spectroscopy
volume
69
issue
3
pages
389 - 397
publisher
Society for Applied Spectroscopy
external identifiers
  • wos:000351982200010
  • scopus:84928799131
ISSN
1943-3530
DOI
10.1366/14-07530
language
English
LU publication?
yes
id
01b5d65e-90ca-425a-8693-80e5bf949e4f (old id 5281436)
date added to LUP
2015-04-24 10:39:31
date last changed
2017-02-12 03:01:24
@article{01b5d65e-90ca-425a-8693-80e5bf949e4f,
  abstract     = {We present a comprehensive study of the application of photon time-of-flight spectroscopy (PTOFS) in the wavelength range 1050 1350 nm as a spectroscopic technique for the evaluation of the chemical composition and structural properties of pharmaceutical tablets. PTOFS is compared to transmission near-infrared spectroscopy (NIRS). In contrast to transmission NIRS, PTOFS is capable of directly and independently determining the absorption and reduced scattering coefficients of the medium. Chemometric models were built on the evaluated absorption spectra for predicting tablet drug concentration. Results are compared to corresponding predictions built on transmission NIRS measurements. The predictive ability of PTOFS and transmission NIRS is comparable when models are based on uniformly distributed tablet sets. For non-uniform distribution of tablets based on particle sizes, the prediction ability of PTOFS is better than that of transmission NIRS. Analysis of reduced scattering spectra shows that PTOFS is able to characterize tablet microstructure and manufacturing process parameters. In contrast to the chemometric pseudovariables provided by transmission NIRS, PTOFS provides physically meaningful quantities such as scattering strength and slope of particle size. The ability of PTOFS to quantify the reduced scattering spectra, together with its robustness in predicting drug content, makes it suitable for such evaluations in the pharmaceutical industry.},
  author       = {Kamran, Faisal and Abildgaard, Otto H. A. and Sparen, Anders and Svensson, Olof and Johansson, Jonas and Andersson-Engels, Stefan and Andersen, Peter E. and Khoptyar, Dmitry},
  issn         = {1943-3530},
  keyword      = {scattering,Multiple,Turbid media,Spectroscopy,Scattering measurements,condensed matter},
  language     = {eng},
  number       = {3},
  pages        = {389--397},
  publisher    = {Society for Applied Spectroscopy},
  series       = {Applied Spectroscopy},
  title        = {Transmission Near-Infrared (NIR) and Photon Time-of-Flight (PTOF) Spectroscopy in a Comparative Analysis of Pharmaceuticals},
  url          = {http://dx.doi.org/10.1366/14-07530},
  volume       = {69},
  year         = {2015},
}