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Surface Composition and Morphology of Particles Dried Individually and by Spray Drying

Nuzzo, Marine LU ; Millqvist-Fureby, Anna; Sloth, Jakob and Bergenståhl, Björn LU (2015) In Drying Technology 33(6). p.757-767
Abstract
This study investigates how the morphology of spray-dried particles is related to the formulation and properties of the components in the formulation. Further, the scale effects in comparisons of levitation-dried single particles and spray-dried particles in a lab-scale spray dryer have been addressed. The Drying Kinetics Analyzer (TM) generates single particles from a levitated drop under simulated spray-drying conditions. A set of surface-active polymers (bovine serum albumin, hydroxypropyl methyl cellulose, and triblock co-polymer Poloxamer), in combination with lactose, were analyzed for their dynamic surface properties in solution, and their effect on particle morphology and surface composition were determined by low-vacuum SEM and... (More)
This study investigates how the morphology of spray-dried particles is related to the formulation and properties of the components in the formulation. Further, the scale effects in comparisons of levitation-dried single particles and spray-dried particles in a lab-scale spray dryer have been addressed. The Drying Kinetics Analyzer (TM) generates single particles from a levitated drop under simulated spray-drying conditions. A set of surface-active polymers (bovine serum albumin, hydroxypropyl methyl cellulose, and triblock co-polymer Poloxamer), in combination with lactose, were analyzed for their dynamic surface properties in solution, and their effect on particle morphology and surface composition were determined by low-vacuum SEM and XPS analyses. The morphology obtained in spray drying was reproduced in the single-particle drying. The surface compositions were also similar, but higher levels of surface-active materials were found at the surface of the single particles as compared to the spray-dried particles. Further, the adsorption rate of surface-active compounds at the drop surface estimated by dynamic surface tension was found to be an important parameter to estimate the surface composition at different drying scales. The particle morphology was primarily determined by the surface rheological properties of the feed solution and, to a lesser extent, by the surface composition. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Levitated single particles, Morphology, Spray drying, Surface, composition, Surface rheology
in
Drying Technology
volume
33
issue
6
pages
757 - 767
publisher
TAPPI
external identifiers
  • wos:000352000300012
  • scopus:84925715335
ISSN
1532-2300
DOI
10.1080/07373937.2014.990566
language
English
LU publication?
yes
id
e33eb898-f3e5-4250-9dbf-e3097f3fa949 (old id 5281616)
date added to LUP
2015-04-24 11:05:10
date last changed
2017-09-24 03:21:04
@article{e33eb898-f3e5-4250-9dbf-e3097f3fa949,
  abstract     = {This study investigates how the morphology of spray-dried particles is related to the formulation and properties of the components in the formulation. Further, the scale effects in comparisons of levitation-dried single particles and spray-dried particles in a lab-scale spray dryer have been addressed. The Drying Kinetics Analyzer (TM) generates single particles from a levitated drop under simulated spray-drying conditions. A set of surface-active polymers (bovine serum albumin, hydroxypropyl methyl cellulose, and triblock co-polymer Poloxamer), in combination with lactose, were analyzed for their dynamic surface properties in solution, and their effect on particle morphology and surface composition were determined by low-vacuum SEM and XPS analyses. The morphology obtained in spray drying was reproduced in the single-particle drying. The surface compositions were also similar, but higher levels of surface-active materials were found at the surface of the single particles as compared to the spray-dried particles. Further, the adsorption rate of surface-active compounds at the drop surface estimated by dynamic surface tension was found to be an important parameter to estimate the surface composition at different drying scales. The particle morphology was primarily determined by the surface rheological properties of the feed solution and, to a lesser extent, by the surface composition.},
  author       = {Nuzzo, Marine and Millqvist-Fureby, Anna and Sloth, Jakob and Bergenståhl, Björn},
  issn         = {1532-2300},
  keyword      = {Levitated single particles,Morphology,Spray drying,Surface,composition,Surface rheology},
  language     = {eng},
  number       = {6},
  pages        = {757--767},
  publisher    = {TAPPI},
  series       = {Drying Technology},
  title        = {Surface Composition and Morphology of Particles Dried Individually and by Spray Drying},
  url          = {http://dx.doi.org/10.1080/07373937.2014.990566},
  volume       = {33},
  year         = {2015},
}