Advanced

Xylose fermentation as a challenge for commercialization of lignocellulosic fuels and chemicals

Sanchez Nogue, Violeta LU and Karhumaa, Kaisa LU (2015) In Biotechnology Letters 37(4). p.761-772
Abstract
Fuel ethanol production from lignocellulosic materials is at a level where commercial biofuel production is becoming a reality. The solubilization of the hemicellulose fraction in lignocellulosic-based feedstocks results in a large variety of sugar mixtures including xylose. However, allowing xylose fermentation in yeast that normally is used for fuel ethanol production requires genetic engineering. Moreover, the efficiency of lignocellulosic pretreatment, together with the release and generation of inhibitory compounds in this step, are some of the new challenges faced during second generation ethanol production. Successful advances in all these aspects will improve ethanol yield, productivity and titer, which will reduce the impact on... (More)
Fuel ethanol production from lignocellulosic materials is at a level where commercial biofuel production is becoming a reality. The solubilization of the hemicellulose fraction in lignocellulosic-based feedstocks results in a large variety of sugar mixtures including xylose. However, allowing xylose fermentation in yeast that normally is used for fuel ethanol production requires genetic engineering. Moreover, the efficiency of lignocellulosic pretreatment, together with the release and generation of inhibitory compounds in this step, are some of the new challenges faced during second generation ethanol production. Successful advances in all these aspects will improve ethanol yield, productivity and titer, which will reduce the impact on capital and operating costs, leading to the consolidation of the fermentation of lignocellulosic biomass as an economically feasible option for the production of renewable fuels. Therefore the development of yeast strains capable of fermenting a wide variety of sugars in a highly inhibitory environment, while maintaining a high ethanol yield and production rate, is required. This review provides an overview of the current status in the use of xylose-engineered yeast strains and describes the remaining challenges to achieve an efficient deployment of lignocellulosic-based ethanol production. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biofuel, Ethanol, Lignocellulosic ethanol, Metabolic engineering, Saccharomyces cerevisiae, Xylose fermentation, Yeast
in
Biotechnology Letters
volume
37
issue
4
pages
761 - 772
publisher
Springer
external identifiers
  • wos:000351535300003
  • scopus:84925489058
ISSN
1573-6776
DOI
10.1007/s10529-014-1756-2
language
English
LU publication?
yes
id
85a7f76e-46f4-4418-843f-45a7ddc7a6a5 (old id 5281867)
date added to LUP
2015-04-24 12:42:11
date last changed
2017-11-19 03:45:08
@article{85a7f76e-46f4-4418-843f-45a7ddc7a6a5,
  abstract     = {Fuel ethanol production from lignocellulosic materials is at a level where commercial biofuel production is becoming a reality. The solubilization of the hemicellulose fraction in lignocellulosic-based feedstocks results in a large variety of sugar mixtures including xylose. However, allowing xylose fermentation in yeast that normally is used for fuel ethanol production requires genetic engineering. Moreover, the efficiency of lignocellulosic pretreatment, together with the release and generation of inhibitory compounds in this step, are some of the new challenges faced during second generation ethanol production. Successful advances in all these aspects will improve ethanol yield, productivity and titer, which will reduce the impact on capital and operating costs, leading to the consolidation of the fermentation of lignocellulosic biomass as an economically feasible option for the production of renewable fuels. Therefore the development of yeast strains capable of fermenting a wide variety of sugars in a highly inhibitory environment, while maintaining a high ethanol yield and production rate, is required. This review provides an overview of the current status in the use of xylose-engineered yeast strains and describes the remaining challenges to achieve an efficient deployment of lignocellulosic-based ethanol production.},
  author       = {Sanchez Nogue, Violeta and Karhumaa, Kaisa},
  issn         = {1573-6776},
  keyword      = {Biofuel,Ethanol,Lignocellulosic ethanol,Metabolic engineering,Saccharomyces cerevisiae,Xylose fermentation,Yeast},
  language     = {eng},
  number       = {4},
  pages        = {761--772},
  publisher    = {Springer},
  series       = {Biotechnology Letters},
  title        = {Xylose fermentation as a challenge for commercialization of lignocellulosic fuels and chemicals},
  url          = {http://dx.doi.org/10.1007/s10529-014-1756-2},
  volume       = {37},
  year         = {2015},
}