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Salvage cryotherapy for local recurrence after radiotherapy for prostate cancer

Ternov, Klara Kvorning; Krag Jakobsen, Ane LU ; Bratt, Ola LU and Ahlgren, Göran LU (2015) In Scandinavian Journal of Urology2013-01-01+01:00 49(2). p.115-119
Abstract
Objective. The aim of this study was to present the outcome of patients treated with salvage cryotherapy after radiotherapy for prostate cancer at one institution. Materials and methods. Consecutive patients treated between 2007 and 2013 with transperineal cryotherapy for biopsy-verified local recurrence after radiotherapy were investigated. An external reviewer retrieved outcome data retrospectively from medical records. Complications were graded according to the Clavien classification. One patient with less than 1 year of follow-up was excluded from the analysis of side-effects. Results. Thirty patients were included, 29 of whom had a follow-up of at least 1 year. The median follow-up was 2.7 years (range 1-6.5 years). Eleven of the 23... (More)
Objective. The aim of this study was to present the outcome of patients treated with salvage cryotherapy after radiotherapy for prostate cancer at one institution. Materials and methods. Consecutive patients treated between 2007 and 2013 with transperineal cryotherapy for biopsy-verified local recurrence after radiotherapy were investigated. An external reviewer retrieved outcome data retrospectively from medical records. Complications were graded according to the Clavien classification. One patient with less than 1 year of follow-up was excluded from the analysis of side-effects. Results. Thirty patients were included, 29 of whom had a follow-up of at least 1 year. The median follow-up was 2.7 years (range 1-6.5 years). Eleven of the 23 patients without hormonal treatment at the time of cryotherapy reached a prostate-specific antigen (PSA) nadir of less than 0.5 ng/ml. At the end of follow-up five of these 23 patients still had a PSA below 0.5 ng/ml and 10 were free from recurrence according to the Phoenix definition. Clinical recurrence (verified with imaging or biopsies) was detected in 13 patients, six of which were local. One patient died from prostate cancer. Eleven patients had urinary incontinence grade 1-2 and three had grade 3-4, seven had pelvic pain, three had severe but transitory tissue sloughing, three developed a urethral stricture or had prolonged urinary retention, and one developed a urinary fistula 4.5 years after cryotherapy. Conclusions. Salvage cryotherapy should be considered as an alternative to hormonal treatment and surgery for local recurrence after radiotherapy for prostate cancer. The results compare well to those reported from centres with longer experience. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cryotherapy, prostate cancer, salvage
in
Scandinavian Journal of Urology2013-01-01+01:00
volume
49
issue
2
pages
115 - 119
publisher
Taylor & Francis
external identifiers
  • wos:000351395600006
  • scopus:84924980600
ISSN
2168-1813
DOI
10.3109/21681805.2014.968869
language
English
LU publication?
yes
id
a5e5a422-baaf-4307-a67a-0acee63c5b03 (old id 5281983)
date added to LUP
2015-05-04 08:53:08
date last changed
2017-09-24 03:13:46
@article{a5e5a422-baaf-4307-a67a-0acee63c5b03,
  abstract     = {Objective. The aim of this study was to present the outcome of patients treated with salvage cryotherapy after radiotherapy for prostate cancer at one institution. Materials and methods. Consecutive patients treated between 2007 and 2013 with transperineal cryotherapy for biopsy-verified local recurrence after radiotherapy were investigated. An external reviewer retrieved outcome data retrospectively from medical records. Complications were graded according to the Clavien classification. One patient with less than 1 year of follow-up was excluded from the analysis of side-effects. Results. Thirty patients were included, 29 of whom had a follow-up of at least 1 year. The median follow-up was 2.7 years (range 1-6.5 years). Eleven of the 23 patients without hormonal treatment at the time of cryotherapy reached a prostate-specific antigen (PSA) nadir of less than 0.5 ng/ml. At the end of follow-up five of these 23 patients still had a PSA below 0.5 ng/ml and 10 were free from recurrence according to the Phoenix definition. Clinical recurrence (verified with imaging or biopsies) was detected in 13 patients, six of which were local. One patient died from prostate cancer. Eleven patients had urinary incontinence grade 1-2 and three had grade 3-4, seven had pelvic pain, three had severe but transitory tissue sloughing, three developed a urethral stricture or had prolonged urinary retention, and one developed a urinary fistula 4.5 years after cryotherapy. Conclusions. Salvage cryotherapy should be considered as an alternative to hormonal treatment and surgery for local recurrence after radiotherapy for prostate cancer. The results compare well to those reported from centres with longer experience.},
  author       = {Ternov, Klara Kvorning and Krag Jakobsen, Ane and Bratt, Ola and Ahlgren, Göran},
  issn         = {2168-1813},
  keyword      = {Cryotherapy,prostate cancer,salvage},
  language     = {eng},
  number       = {2},
  pages        = {115--119},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Urology2013-01-01+01:00},
  title        = {Salvage cryotherapy for local recurrence after radiotherapy for prostate cancer},
  url          = {http://dx.doi.org/10.3109/21681805.2014.968869},
  volume       = {49},
  year         = {2015},
}