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Computationally effective solution of the inverse problem in time-of-flight spectroscopy

Kamran, Faisal; Abildgaard, Otto H. A.; Subash, Arman LU ; Andersen, Peter E.; Andersson-Engels, Stefan LU and Khoptyar, Dmitry (2015) In Optics Express 23(5). p.6937-6945
Abstract
Photon time-of-flight (PTOF) spectroscopy enables the estimation of absorption and reduced scattering coefficients of turbid media by measuring the propagation time of short light pulses through turbid medium. The present investigation provides a comparison of the assessed absorption and reduced scattering coefficients from PTOF measurements of intralipid 20% and India ink-based optical phantoms covering a wide range of optical properties relevant for biological tissues and dairy products. Three different models are used to obtain the optical properties by fitting to measured temporal profiles: the Liemert-Kienle model (LKM), the diffusion model (DM) and a white Monte-Carlo (WMC) simulation-based algorithm. For the infinite space geometry,... (More)
Photon time-of-flight (PTOF) spectroscopy enables the estimation of absorption and reduced scattering coefficients of turbid media by measuring the propagation time of short light pulses through turbid medium. The present investigation provides a comparison of the assessed absorption and reduced scattering coefficients from PTOF measurements of intralipid 20% and India ink-based optical phantoms covering a wide range of optical properties relevant for biological tissues and dairy products. Three different models are used to obtain the optical properties by fitting to measured temporal profiles: the Liemert-Kienle model (LKM), the diffusion model (DM) and a white Monte-Carlo (WMC) simulation-based algorithm. For the infinite space geometry, a very good agreement is found between the LKM and WMC, while the results obtained by the DM differ, indicating that the LKM can provide accurate estimation of the optical parameters beyond the limits of the diffusion approximation in a computational effective and accurate manner. This result increases the potential range of applications for PTOF spectroscopy within industrial and biomedical applications. (C) 2015 Optical Society of America (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Optics Express
volume
23
issue
5
pages
6937 - 6945
publisher
OSA
external identifiers
  • wos:000350878500140
  • scopus:84981313428
ISSN
1094-4087
DOI
10.1364/OE.23.006937
language
English
LU publication?
yes
id
c7aaec41-bbc2-408e-9721-9fab0c013ea5 (old id 5294074)
date added to LUP
2015-04-27 08:45:01
date last changed
2017-01-01 06:06:10
@article{c7aaec41-bbc2-408e-9721-9fab0c013ea5,
  abstract     = {Photon time-of-flight (PTOF) spectroscopy enables the estimation of absorption and reduced scattering coefficients of turbid media by measuring the propagation time of short light pulses through turbid medium. The present investigation provides a comparison of the assessed absorption and reduced scattering coefficients from PTOF measurements of intralipid 20% and India ink-based optical phantoms covering a wide range of optical properties relevant for biological tissues and dairy products. Three different models are used to obtain the optical properties by fitting to measured temporal profiles: the Liemert-Kienle model (LKM), the diffusion model (DM) and a white Monte-Carlo (WMC) simulation-based algorithm. For the infinite space geometry, a very good agreement is found between the LKM and WMC, while the results obtained by the DM differ, indicating that the LKM can provide accurate estimation of the optical parameters beyond the limits of the diffusion approximation in a computational effective and accurate manner. This result increases the potential range of applications for PTOF spectroscopy within industrial and biomedical applications. (C) 2015 Optical Society of America},
  author       = {Kamran, Faisal and Abildgaard, Otto H. A. and Subash, Arman and Andersen, Peter E. and Andersson-Engels, Stefan and Khoptyar, Dmitry},
  issn         = {1094-4087},
  language     = {eng},
  number       = {5},
  pages        = {6937--6945},
  publisher    = {OSA},
  series       = {Optics Express},
  title        = {Computationally effective solution of the inverse problem in time-of-flight spectroscopy},
  url          = {http://dx.doi.org/10.1364/OE.23.006937},
  volume       = {23},
  year         = {2015},
}