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The role of the laboratory in diagnosis and management of inhibitory antibodies in haemophilia

Strandberg, K. LU and Astermark, J. LU (2018) In Haemophilia 24. p.9-14
Abstract

The treatment of patients with haemophilia A has remarkably improved over the years and the journey to a potential cure continues. Replacement therapy has been the cornerstone of treatment, and, despite major advances, the development of neutralizing antibodies, eg inhibitors, has thus far not been possible to avoid. How, and to what extent, the new non-factor-based options will modify treatment strategy and inhibitor risk is unclear and it is essential that every haemophilia treatment centre is linked to an educated and skilled laboratory performing the relevant inhibitor assays. The current review will focus on when to consider and how to perform inhibitor assay(s) in the management of patients with haemophilia A.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
haemophilia, inhibitors, laboratory, methods
in
Haemophilia
volume
24
pages
6 pages
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:85047993021
ISSN
1351-8216
DOI
language
English
LU publication?
yes
id
52b01cfb-ccc9-46c2-8153-6a21a348b16b
date added to LUP
2018-06-13 15:52:41
date last changed
2018-06-14 03:00:07
@article{52b01cfb-ccc9-46c2-8153-6a21a348b16b,
  abstract     = {<p>The treatment of patients with haemophilia A has remarkably improved over the years and the journey to a potential cure continues. Replacement therapy has been the cornerstone of treatment, and, despite major advances, the development of neutralizing antibodies, eg inhibitors, has thus far not been possible to avoid. How, and to what extent, the new non-factor-based options will modify treatment strategy and inhibitor risk is unclear and it is essential that every haemophilia treatment centre is linked to an educated and skilled laboratory performing the relevant inhibitor assays. The current review will focus on when to consider and how to perform inhibitor assay(s) in the management of patients with haemophilia A.</p>},
  author       = {Strandberg, K. and Astermark, J.},
  issn         = {1351-8216},
  keyword      = {haemophilia,inhibitors,laboratory,methods},
  language     = {eng},
  month        = {05},
  pages        = {9--14},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Haemophilia},
  title        = {The role of the laboratory in diagnosis and management of inhibitory antibodies in haemophilia},
  url          = {http://dx.doi.org/},
  volume       = {24},
  year         = {2018},
}