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Nemo-like kinase in development and diseases : Insights from mouse studies

Daams, Renée LU and Massoumi, Ramin LU (2020) In International Journal of Molecular Sciences 21(23). p.1-8
Abstract

The Wnt signalling pathway is a central communication cascade between cells to orchestrate polarity and fate during development and adult tissue homeostasis in various organisms. This pathway can be regulated by different signalling molecules in several steps. One of the coordinators in this pathway is Nemo-like kinase (NLK), which is an atypical proline-directed serine/threonine mitogen-activated protein (MAP) kinase. Very recently, NLK was established as an essential regulator in different cellular processes and abnormal NLK expression was highlighted to affect the development and progression of various diseases. In this review, we focused on the recent discoveries by using NLK-deficient mice, which show a phenotype in the development... (More)

The Wnt signalling pathway is a central communication cascade between cells to orchestrate polarity and fate during development and adult tissue homeostasis in various organisms. This pathway can be regulated by different signalling molecules in several steps. One of the coordinators in this pathway is Nemo-like kinase (NLK), which is an atypical proline-directed serine/threonine mitogen-activated protein (MAP) kinase. Very recently, NLK was established as an essential regulator in different cellular processes and abnormal NLK expression was highlighted to affect the development and progression of various diseases. In this review, we focused on the recent discoveries by using NLK-deficient mice, which show a phenotype in the development and function of organs such as the lung, heart and skeleton. Furthermore, NLK could conduct the function and differentiation of cells from the immune system, in addition to regulating neurodegenerative diseases, such as Huntington’s disease and spinocerebellar ataxias. Overall, generations of NLK-deficient mice have taught us valuable lessons about the role of this kinase in certain diseases and development.

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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animal models, Development, Immune system neuronal disorders, Mice, Nemo-like kinase (NLK)
in
International Journal of Molecular Sciences
volume
21
issue
23
article number
9203
pages
8 pages
publisher
MDPI AG
external identifiers
  • scopus:85097109391
  • pmid:33276680
ISSN
1661-6596
DOI
10.3390/ijms21239203
language
English
LU publication?
yes
id
52dc1c70-6322-4496-8b01-f8a4afb356e1
date added to LUP
2021-01-15 10:48:58
date last changed
2024-06-27 07:06:01
@article{52dc1c70-6322-4496-8b01-f8a4afb356e1,
  abstract     = {{<p>The Wnt signalling pathway is a central communication cascade between cells to orchestrate polarity and fate during development and adult tissue homeostasis in various organisms. This pathway can be regulated by different signalling molecules in several steps. One of the coordinators in this pathway is Nemo-like kinase (NLK), which is an atypical proline-directed serine/threonine mitogen-activated protein (MAP) kinase. Very recently, NLK was established as an essential regulator in different cellular processes and abnormal NLK expression was highlighted to affect the development and progression of various diseases. In this review, we focused on the recent discoveries by using NLK-deficient mice, which show a phenotype in the development and function of organs such as the lung, heart and skeleton. Furthermore, NLK could conduct the function and differentiation of cells from the immune system, in addition to regulating neurodegenerative diseases, such as Huntington’s disease and spinocerebellar ataxias. Overall, generations of NLK-deficient mice have taught us valuable lessons about the role of this kinase in certain diseases and development.</p>}},
  author       = {{Daams, Renée and Massoumi, Ramin}},
  issn         = {{1661-6596}},
  keywords     = {{Animal models; Development; Immune system neuronal disorders; Mice; Nemo-like kinase (NLK)}},
  language     = {{eng}},
  number       = {{23}},
  pages        = {{1--8}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Molecular Sciences}},
  title        = {{Nemo-like kinase in development and diseases : Insights from mouse studies}},
  url          = {{http://dx.doi.org/10.3390/ijms21239203}},
  doi          = {{10.3390/ijms21239203}},
  volume       = {{21}},
  year         = {{2020}},
}