Nemo-like kinase in development and diseases : Insights from mouse studies
(2020) In International Journal of Molecular Sciences 21(23). p.1-8- Abstract
The Wnt signalling pathway is a central communication cascade between cells to orchestrate polarity and fate during development and adult tissue homeostasis in various organisms. This pathway can be regulated by different signalling molecules in several steps. One of the coordinators in this pathway is Nemo-like kinase (NLK), which is an atypical proline-directed serine/threonine mitogen-activated protein (MAP) kinase. Very recently, NLK was established as an essential regulator in different cellular processes and abnormal NLK expression was highlighted to affect the development and progression of various diseases. In this review, we focused on the recent discoveries by using NLK-deficient mice, which show a phenotype in the development... (More)
The Wnt signalling pathway is a central communication cascade between cells to orchestrate polarity and fate during development and adult tissue homeostasis in various organisms. This pathway can be regulated by different signalling molecules in several steps. One of the coordinators in this pathway is Nemo-like kinase (NLK), which is an atypical proline-directed serine/threonine mitogen-activated protein (MAP) kinase. Very recently, NLK was established as an essential regulator in different cellular processes and abnormal NLK expression was highlighted to affect the development and progression of various diseases. In this review, we focused on the recent discoveries by using NLK-deficient mice, which show a phenotype in the development and function of organs such as the lung, heart and skeleton. Furthermore, NLK could conduct the function and differentiation of cells from the immune system, in addition to regulating neurodegenerative diseases, such as Huntington’s disease and spinocerebellar ataxias. Overall, generations of NLK-deficient mice have taught us valuable lessons about the role of this kinase in certain diseases and development.
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- author
- Daams, Renée LU and Massoumi, Ramin LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animal models, Development, Immune system neuronal disorders, Mice, Nemo-like kinase (NLK)
- in
- International Journal of Molecular Sciences
- volume
- 21
- issue
- 23
- article number
- 9203
- pages
- 8 pages
- publisher
- MDPI AG
- external identifiers
-
- scopus:85097109391
- pmid:33276680
- ISSN
- 1661-6596
- DOI
- 10.3390/ijms21239203
- language
- English
- LU publication?
- yes
- id
- 52dc1c70-6322-4496-8b01-f8a4afb356e1
- date added to LUP
- 2021-01-15 10:48:58
- date last changed
- 2024-05-31 07:31:49
@article{52dc1c70-6322-4496-8b01-f8a4afb356e1, abstract = {{<p>The Wnt signalling pathway is a central communication cascade between cells to orchestrate polarity and fate during development and adult tissue homeostasis in various organisms. This pathway can be regulated by different signalling molecules in several steps. One of the coordinators in this pathway is Nemo-like kinase (NLK), which is an atypical proline-directed serine/threonine mitogen-activated protein (MAP) kinase. Very recently, NLK was established as an essential regulator in different cellular processes and abnormal NLK expression was highlighted to affect the development and progression of various diseases. In this review, we focused on the recent discoveries by using NLK-deficient mice, which show a phenotype in the development and function of organs such as the lung, heart and skeleton. Furthermore, NLK could conduct the function and differentiation of cells from the immune system, in addition to regulating neurodegenerative diseases, such as Huntington’s disease and spinocerebellar ataxias. Overall, generations of NLK-deficient mice have taught us valuable lessons about the role of this kinase in certain diseases and development.</p>}}, author = {{Daams, Renée and Massoumi, Ramin}}, issn = {{1661-6596}}, keywords = {{Animal models; Development; Immune system neuronal disorders; Mice; Nemo-like kinase (NLK)}}, language = {{eng}}, number = {{23}}, pages = {{1--8}}, publisher = {{MDPI AG}}, series = {{International Journal of Molecular Sciences}}, title = {{Nemo-like kinase in development and diseases : Insights from mouse studies}}, url = {{http://dx.doi.org/10.3390/ijms21239203}}, doi = {{10.3390/ijms21239203}}, volume = {{21}}, year = {{2020}}, }