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Clinically Relevant Depressive Symptoms in Young Stroke Patients - Results of the sifap1 Study

Tanislav, Christian; Kropp, Peter; Grittner, Ulrike; Holzhausen, Martin; Fazekas, Franz; Jungehuelsing, Gerhard Jan; Tatlisumak, Turgut; von Sarnowski, Bettina; Putaala, Jukka and Huber, Roman, et al. (2015) In Neuroepidemiology 44(1). p.30-38
Abstract
Background: Although post-stroke depression is widely recognized, less is known about depressive symptoms in the acute stage of stroke and especially in young stroke patients. We thus investigated depressive symptoms and their determinants in such a cohort. Methods:The Stroke in Young Fabry Patients study (sifap1) prospectively recruited a large multinational European cohort (n = 5,023) of patients with a cerebrovascular event aged 18-55. For assessing clinically relevant depressive symptoms (CRDS, defined by a BDI-score >= 18) the self-reporting Beck Depression Inventory (BDI) was obtained on inclusion in the study. Associations with baseline parameters, stroke severity (National Institutes of Health Stroke Scale, NIHSS), and brain MRI... (More)
Background: Although post-stroke depression is widely recognized, less is known about depressive symptoms in the acute stage of stroke and especially in young stroke patients. We thus investigated depressive symptoms and their determinants in such a cohort. Methods:The Stroke in Young Fabry Patients study (sifap1) prospectively recruited a large multinational European cohort (n = 5,023) of patients with a cerebrovascular event aged 18-55. For assessing clinically relevant depressive symptoms (CRDS, defined by a BDI-score >= 18) the self-reporting Beck Depression Inventory (BDI) was obtained on inclusion in the study. Associations with baseline parameters, stroke severity (National Institutes of Health Stroke Scale, NIHSS), and brain MRI findings were analyzed. Results: From the 2007 patients with BDI documentation, 202 (10.1%) had CRDS. CRDS were observed more frequently in women (12.6 vs. 8.2% in men, p < 0.001). Patients with CRDS more often had arterial hypertension, diabetes mellitus, and hyperlipidemia than patients without CRDS (hypertension: 58.0 vs. 47.1%, p = 0.017; diabetes mellitus: 17.9 vs. 8.9%, p < 0.001; hyperlipidemia: 40.5 vs. 32.3%, p = 0.012). In the subgroup of patients with ischemic stroke or TIA (n = 1,832) no significant associations between CRDS and cerebral MRI findings such as the presence of acute infarcts (68.1 vs. 65.8%, p = 0.666), old infarctions (63.4 vs. 62.1%, p = 0.725) or white matter hyper-intensities (51.6 vs. 53.7%, p = 0.520) were found. Conclusion: Depressive symptoms were present in 10.1% of young stroke patients in the acute phase, and were related to riskfactors but not to imaging findings. (C) 2015 S. Karger AG, Basel (Less)
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Contribution to journal
publication status
published
subject
keywords
Young stroke, Depression, Acute cerebral ischemia, sifap1, Risk factors
in
Neuroepidemiology
volume
44
issue
1
pages
30 - 38
publisher
Karger
external identifiers
  • wos:000350940200005
  • scopus:84923084722
ISSN
1423-0208
DOI
10.1159/000371389
language
English
LU publication?
yes
id
35e65924-3796-4e67-88ea-98cf8951dd5b (old id 5300307)
date added to LUP
2015-05-04 08:35:25
date last changed
2017-10-08 03:09:45
@article{35e65924-3796-4e67-88ea-98cf8951dd5b,
  abstract     = {Background: Although post-stroke depression is widely recognized, less is known about depressive symptoms in the acute stage of stroke and especially in young stroke patients. We thus investigated depressive symptoms and their determinants in such a cohort. Methods:The Stroke in Young Fabry Patients study (sifap1) prospectively recruited a large multinational European cohort (n = 5,023) of patients with a cerebrovascular event aged 18-55. For assessing clinically relevant depressive symptoms (CRDS, defined by a BDI-score &gt;= 18) the self-reporting Beck Depression Inventory (BDI) was obtained on inclusion in the study. Associations with baseline parameters, stroke severity (National Institutes of Health Stroke Scale, NIHSS), and brain MRI findings were analyzed. Results: From the 2007 patients with BDI documentation, 202 (10.1%) had CRDS. CRDS were observed more frequently in women (12.6 vs. 8.2% in men, p &lt; 0.001). Patients with CRDS more often had arterial hypertension, diabetes mellitus, and hyperlipidemia than patients without CRDS (hypertension: 58.0 vs. 47.1%, p = 0.017; diabetes mellitus: 17.9 vs. 8.9%, p &lt; 0.001; hyperlipidemia: 40.5 vs. 32.3%, p = 0.012). In the subgroup of patients with ischemic stroke or TIA (n = 1,832) no significant associations between CRDS and cerebral MRI findings such as the presence of acute infarcts (68.1 vs. 65.8%, p = 0.666), old infarctions (63.4 vs. 62.1%, p = 0.725) or white matter hyper-intensities (51.6 vs. 53.7%, p = 0.520) were found. Conclusion: Depressive symptoms were present in 10.1% of young stroke patients in the acute phase, and were related to riskfactors but not to imaging findings. (C) 2015 S. Karger AG, Basel},
  author       = {Tanislav, Christian and Kropp, Peter and Grittner, Ulrike and Holzhausen, Martin and Fazekas, Franz and Jungehuelsing, Gerhard Jan and Tatlisumak, Turgut and von Sarnowski, Bettina and Putaala, Jukka and Huber, Roman and Thijs, Vincent and Schmidt, Reinhold and Kaps, Manfred and Enzinger, Christian and Dichgans, Martin and Norrving, Bo and Rolfs, Arndt},
  issn         = {1423-0208},
  keyword      = {Young stroke,Depression,Acute cerebral ischemia,sifap1,Risk factors},
  language     = {eng},
  number       = {1},
  pages        = {30--38},
  publisher    = {Karger},
  series       = {Neuroepidemiology},
  title        = {Clinically Relevant Depressive Symptoms in Young Stroke Patients - Results of the sifap1 Study},
  url          = {http://dx.doi.org/10.1159/000371389},
  volume       = {44},
  year         = {2015},
}