The risk for diabetic nephropathy is low in young adults in a 17-year follow-up from the Diabetes Incidence Study in Sweden (DISS). Older age and higher BMI at diabetes onset can be important risk factors
(2015) In Diabetes/Metabolism Research & Reviews 31(2). p.138-146- Abstract
- AimsThe main objective of this study was to estimate the occurrence of diabetic nephropathy in a population-based cohort of patients diagnosed with diabetes as young adults (15-34years). MethodsAll 794 patients registered 1987-1988 in the Diabetes Incidence Study in Sweden (DISS) were invited to a follow-up study 15-19years after diagnosis, and 468 (58%) participated. Analysis of islet antibodies was used to classify type of diabetes. ResultsAfter median 17years of diabetes, 15% of all patients, 14% T1DM and 25% T2DM, were diagnosed with diabetic nephropathy. Ninety-one percent had microalbuminuria and 8.6% macroalbuminuria. Older age at diagnosis (HR 1.05; 95% CI 1.01-1.10 per year) was an independent and a higher BMI at diabetes... (More)
- AimsThe main objective of this study was to estimate the occurrence of diabetic nephropathy in a population-based cohort of patients diagnosed with diabetes as young adults (15-34years). MethodsAll 794 patients registered 1987-1988 in the Diabetes Incidence Study in Sweden (DISS) were invited to a follow-up study 15-19years after diagnosis, and 468 (58%) participated. Analysis of islet antibodies was used to classify type of diabetes. ResultsAfter median 17years of diabetes, 15% of all patients, 14% T1DM and 25% T2DM, were diagnosed with diabetic nephropathy. Ninety-one percent had microalbuminuria and 8.6% macroalbuminuria. Older age at diagnosis (HR 1.05; 95% CI 1.01-1.10 per year) was an independent and a higher BMI at diabetes diagnosis (HR 1.04; 95% CI 1.00-1.09 per 1kg/m(2)), a near-significant predictor of development of diabetic nephropathy. Age at onset of diabetes (p=0.041), BMI (p=0.012) and HbA1c (p<0.001) were significant predictors of developing diabetic nephropathy between 9 and 17years of diabetes. At 17years of diabetes duration, a high HbA1c level (OR 1.06; 95% CI 1.03-1.08 per 1mmol/mol increase) and systolic blood pressure (OR 1.08; 95% CI 1.051.12 per 1mmHg increase) were associated with DN. ConclusionsPatients with T2DM diagnosed as young adults seem to have an increased risk to develop diabetic nephropathy compared with those with T1DM. Older age and higher BMI at diagnosis of diabetes were risk markers for development of diabetic nephropathy. In addition, poor glycaemic control but not systolic blood pressure at 9years of follow-up was a risk marker for later development of diabetic nephropathy. Copyright (c) 2014 John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5305600
- author
- Svensson, M. K. ; Tyrberg, Maria LU ; Nystrom, L. ; Arnqvist, H. J. ; Bolinder, J. ; Ostman, J. ; Gudbjornsdottir, S. ; Landin-Olsson, Mona LU and Eriksson, J. W.
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- diabetic nephropathy, hyperglycaemia, blood pressure, type 1 diabetes, mellitus, type 2 diabetes mellitus, islet antibodies
- in
- Diabetes/Metabolism Research & Reviews
- volume
- 31
- issue
- 2
- pages
- 138 - 146
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000349969600003
- pmid:25044633
- scopus:85027928816
- ISSN
- 1520-7552
- DOI
- 10.1002/dmrr.2574
- language
- English
- LU publication?
- yes
- id
- 2d3a1891-8f02-4064-8c02-a9db4a7bf1be (old id 5305600)
- date added to LUP
- 2016-04-01 10:29:00
- date last changed
- 2024-12-03 12:55:19
@article{2d3a1891-8f02-4064-8c02-a9db4a7bf1be, abstract = {{AimsThe main objective of this study was to estimate the occurrence of diabetic nephropathy in a population-based cohort of patients diagnosed with diabetes as young adults (15-34years). MethodsAll 794 patients registered 1987-1988 in the Diabetes Incidence Study in Sweden (DISS) were invited to a follow-up study 15-19years after diagnosis, and 468 (58%) participated. Analysis of islet antibodies was used to classify type of diabetes. ResultsAfter median 17years of diabetes, 15% of all patients, 14% T1DM and 25% T2DM, were diagnosed with diabetic nephropathy. Ninety-one percent had microalbuminuria and 8.6% macroalbuminuria. Older age at diagnosis (HR 1.05; 95% CI 1.01-1.10 per year) was an independent and a higher BMI at diabetes diagnosis (HR 1.04; 95% CI 1.00-1.09 per 1kg/m(2)), a near-significant predictor of development of diabetic nephropathy. Age at onset of diabetes (p=0.041), BMI (p=0.012) and HbA1c (p<0.001) were significant predictors of developing diabetic nephropathy between 9 and 17years of diabetes. At 17years of diabetes duration, a high HbA1c level (OR 1.06; 95% CI 1.03-1.08 per 1mmol/mol increase) and systolic blood pressure (OR 1.08; 95% CI 1.051.12 per 1mmHg increase) were associated with DN. ConclusionsPatients with T2DM diagnosed as young adults seem to have an increased risk to develop diabetic nephropathy compared with those with T1DM. Older age and higher BMI at diagnosis of diabetes were risk markers for development of diabetic nephropathy. In addition, poor glycaemic control but not systolic blood pressure at 9years of follow-up was a risk marker for later development of diabetic nephropathy. Copyright (c) 2014 John Wiley & Sons, Ltd.}}, author = {{Svensson, M. K. and Tyrberg, Maria and Nystrom, L. and Arnqvist, H. J. and Bolinder, J. and Ostman, J. and Gudbjornsdottir, S. and Landin-Olsson, Mona and Eriksson, J. W.}}, issn = {{1520-7552}}, keywords = {{diabetic nephropathy; hyperglycaemia; blood pressure; type 1 diabetes; mellitus; type 2 diabetes mellitus; islet antibodies}}, language = {{eng}}, number = {{2}}, pages = {{138--146}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Diabetes/Metabolism Research & Reviews}}, title = {{The risk for diabetic nephropathy is low in young adults in a 17-year follow-up from the Diabetes Incidence Study in Sweden (DISS). Older age and higher BMI at diabetes onset can be important risk factors}}, url = {{http://dx.doi.org/10.1002/dmrr.2574}}, doi = {{10.1002/dmrr.2574}}, volume = {{31}}, year = {{2015}}, }