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Drug delivery to retinal photoreceptors

Himawan, Erico ; Ekström, Per LU ; Buzgo, Matej ; Gaillard, Pieter ; Stefánsson, Einar ; Marigo, Valeria ; Loftsson, Thorsteinn and Paquet-Durand, François LU (2019) In Drug Discovery Today 24(8). p.1637-1643
Abstract

The photoreceptors of the retina are afflicted by diseases that still often lack satisfactory treatment options. Although suitable drugs might be available in some cases, the delivery of these compounds into the eye and across the blood–retinal barrier remains a significant challenge for therapy development. Here, we review the routes of drug administration to the retina and highlight different options for drug delivery to the photoreceptor cells.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Drug Discovery Today
volume
24
issue
8
pages
1637 - 1643
publisher
Elsevier
external identifiers
  • scopus:85063296590
  • pmid:30877076
ISSN
1359-6446
DOI
10.1016/j.drudis.2019.03.004
language
English
LU publication?
yes
id
532c8f82-77c5-459b-b742-4852073780bc
date added to LUP
2019-04-08 13:16:51
date last changed
2024-06-11 08:03:44
@article{532c8f82-77c5-459b-b742-4852073780bc,
  abstract     = {{<p>The photoreceptors of the retina are afflicted by diseases that still often lack satisfactory treatment options. Although suitable drugs might be available in some cases, the delivery of these compounds into the eye and across the blood–retinal barrier remains a significant challenge for therapy development. Here, we review the routes of drug administration to the retina and highlight different options for drug delivery to the photoreceptor cells.</p>}},
  author       = {{Himawan, Erico and Ekström, Per and Buzgo, Matej and Gaillard, Pieter and Stefánsson, Einar and Marigo, Valeria and Loftsson, Thorsteinn and Paquet-Durand, François}},
  issn         = {{1359-6446}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1637--1643}},
  publisher    = {{Elsevier}},
  series       = {{Drug Discovery Today}},
  title        = {{Drug delivery to retinal photoreceptors}},
  url          = {{http://dx.doi.org/10.1016/j.drudis.2019.03.004}},
  doi          = {{10.1016/j.drudis.2019.03.004}},
  volume       = {{24}},
  year         = {{2019}},
}