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Isolation and characterization of two verrucarins from Myrothecium roridum

Schoettler, Sylvia ; Bascope, Marcelo LU ; Sterner, Olov LU and Anke, Timm (2006) In Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences 61(5-6). p.309-314
Abstract
In the course of a screening for compounds inhibiting the growth of two human breast cancer cells lines, two highly cytotoxic compounds were isolated from fermentations of Myrothecium roridum. The elucidation of their structures revealed that they are macrocyclic trichothecenes of the verrucarin type, 16-hydroxyverrucarin A (1), reported here as a natural product for the first time, and verrucarin X (2), a new compound. Both 1 and 2 exhibit moderate antifungal activity and pronounced cytotoxic activity, with IC50 values in the nanomolar (1) and micromolar (2) range. Both compounds preferentially inhibit in vivo protein biosynthesis.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Myrothecium roridum, 16-hydroxyverrucarin A, verrucarin X, protein, synthesis inhibitors
in
Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences
volume
61
issue
5-6
pages
309 - 314
publisher
Verlag der Zeitschrift für Naturforschung
external identifiers
  • wos:000239444300001
  • scopus:33746042552
ISSN
0939-5075
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
5336a155-c106-47b6-985f-2c9f3a9dfe55 (old id 398583)
alternative location
http://www.znaturforsch.com/ac/v61c/c61c.htm#No5
date added to LUP
2016-04-01 17:05:17
date last changed
2020-01-30 01:34:49
@article{5336a155-c106-47b6-985f-2c9f3a9dfe55,
  abstract     = {In the course of a screening for compounds inhibiting the growth of two human breast cancer cells lines, two highly cytotoxic compounds were isolated from fermentations of Myrothecium roridum. The elucidation of their structures revealed that they are macrocyclic trichothecenes of the verrucarin type, 16-hydroxyverrucarin A (1), reported here as a natural product for the first time, and verrucarin X (2), a new compound. Both 1 and 2 exhibit moderate antifungal activity and pronounced cytotoxic activity, with IC50 values in the nanomolar (1) and micromolar (2) range. Both compounds preferentially inhibit in vivo protein biosynthesis.},
  author       = {Schoettler, Sylvia and Bascope, Marcelo and Sterner, Olov and Anke, Timm},
  issn         = {0939-5075},
  language     = {eng},
  number       = {5-6},
  pages        = {309--314},
  publisher    = {Verlag der Zeitschrift für Naturforschung},
  series       = {Zeitschrift fuer Naturforschung. Section C: A Journal of Biosciences},
  title        = {Isolation and characterization of two verrucarins from Myrothecium roridum},
  url          = {http://www.znaturforsch.com/ac/v61c/c61c.htm#No5},
  volume       = {61},
  year         = {2006},
}