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X-ray phase-contrast tomography with a compact laser-driven synchrotron source.

Eggl, Elena; Schleede, Simone; Bech, Martin LU ; Achterhold, Klaus; Loewen, Roderick; Ruth, Ronald D and Pfeiffer, Franz (2015) In Proceedings of the National Academy of Sciences 112(18). p.5567-5572
Abstract
Between X-ray tubes and large-scale synchrotron sources, a large gap in performance exists with respect to the monochromaticity and brilliance of the X-ray beam. However, due to their size and cost, large-scale synchrotrons are not available for more routine applications in small and medium-sized academic or industrial laboratories. This gap could be closed by laser-driven compact synchrotron light sources (CLS), which use an infrared (IR) laser cavity in combination with a small electron storage ring. Hard X-rays are produced through the process of inverse Compton scattering upon the intersection of the electron bunch with the focused laser beam. The produced X-ray beam is intrinsically monochromatic and highly collimated. This makes a... (More)
Between X-ray tubes and large-scale synchrotron sources, a large gap in performance exists with respect to the monochromaticity and brilliance of the X-ray beam. However, due to their size and cost, large-scale synchrotrons are not available for more routine applications in small and medium-sized academic or industrial laboratories. This gap could be closed by laser-driven compact synchrotron light sources (CLS), which use an infrared (IR) laser cavity in combination with a small electron storage ring. Hard X-rays are produced through the process of inverse Compton scattering upon the intersection of the electron bunch with the focused laser beam. The produced X-ray beam is intrinsically monochromatic and highly collimated. This makes a CLS well-suited for applications of more advanced--and more challenging--X-ray imaging approaches, such as X-ray multimodal tomography. Here we present, to our knowledge, the first results of a first successful demonstration experiment in which a monochromatic X-ray beam from a CLS was used for multimodal, i.e., phase-, dark-field, and attenuation-contrast, X-ray tomography. We show results from a fluid phantom with different liquids and a biomedical application example in the form of a multimodal CT scan of a small animal (mouse, ex vivo). The results highlight particularly that quantitative multimodal CT has become feasible with laser-driven CLS, and that the results outperform more conventional approaches. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Proceedings of the National Academy of Sciences
volume
112
issue
18
pages
5567 - 5572
publisher
National Acad Sciences
external identifiers
  • pmid:25902493
  • wos:000353953800031
  • scopus:84928957996
ISSN
1091-6490
DOI
10.1073/pnas.1500938112
language
English
LU publication?
yes
id
4e226853-c6f0-4aed-a443-f2b27d2b9b41 (old id 5340949)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25902493?dopt=Abstract
date added to LUP
2015-05-02 15:28:09
date last changed
2017-11-19 03:11:07
@article{4e226853-c6f0-4aed-a443-f2b27d2b9b41,
  abstract     = {Between X-ray tubes and large-scale synchrotron sources, a large gap in performance exists with respect to the monochromaticity and brilliance of the X-ray beam. However, due to their size and cost, large-scale synchrotrons are not available for more routine applications in small and medium-sized academic or industrial laboratories. This gap could be closed by laser-driven compact synchrotron light sources (CLS), which use an infrared (IR) laser cavity in combination with a small electron storage ring. Hard X-rays are produced through the process of inverse Compton scattering upon the intersection of the electron bunch with the focused laser beam. The produced X-ray beam is intrinsically monochromatic and highly collimated. This makes a CLS well-suited for applications of more advanced--and more challenging--X-ray imaging approaches, such as X-ray multimodal tomography. Here we present, to our knowledge, the first results of a first successful demonstration experiment in which a monochromatic X-ray beam from a CLS was used for multimodal, i.e., phase-, dark-field, and attenuation-contrast, X-ray tomography. We show results from a fluid phantom with different liquids and a biomedical application example in the form of a multimodal CT scan of a small animal (mouse, ex vivo). The results highlight particularly that quantitative multimodal CT has become feasible with laser-driven CLS, and that the results outperform more conventional approaches.},
  author       = {Eggl, Elena and Schleede, Simone and Bech, Martin and Achterhold, Klaus and Loewen, Roderick and Ruth, Ronald D and Pfeiffer, Franz},
  issn         = {1091-6490},
  language     = {eng},
  number       = {18},
  pages        = {5567--5572},
  publisher    = {National Acad Sciences},
  series       = {Proceedings of the National Academy of Sciences},
  title        = {X-ray phase-contrast tomography with a compact laser-driven synchrotron source.},
  url          = {http://dx.doi.org/10.1073/pnas.1500938112},
  volume       = {112},
  year         = {2015},
}