X-ray phase-contrast tomography with a compact laser-driven synchrotron source.
Eggl, Elena ; Schleede, Simone ; Bech, Martin LU
; Achterhold, Klaus
; Loewen, Roderick
; Ruth, Ronald D
and Pfeiffer, Franz
(2015)
In Proceedings of the National Academy of Sciences
112(18).
p.5567-5572
- Abstract
- Between X-ray tubes and large-scale synchrotron sources, a large gap in performance exists with respect to the monochromaticity and brilliance of the X-ray beam. However, due to their size and cost, large-scale synchrotrons are not available for more routine applications in small and medium-sized academic or industrial laboratories. This gap could be closed by laser-driven compact synchrotron light sources (CLS), which use an infrared (IR) laser cavity in combination with a small electron storage ring. Hard X-rays are produced through the process of inverse Compton scattering upon the intersection of the electron bunch with the focused laser beam. The produced X-ray beam is intrinsically monochromatic and highly collimated. This makes a... (More)
- Between X-ray tubes and large-scale synchrotron sources, a large gap in performance exists with respect to the monochromaticity and brilliance of the X-ray beam. However, due to their size and cost, large-scale synchrotrons are not available for more routine applications in small and medium-sized academic or industrial laboratories. This gap could be closed by laser-driven compact synchrotron light sources (CLS), which use an infrared (IR) laser cavity in combination with a small electron storage ring. Hard X-rays are produced through the process of inverse Compton scattering upon the intersection of the electron bunch with the focused laser beam. The produced X-ray beam is intrinsically monochromatic and highly collimated. This makes a CLS well-suited for applications of more advanced--and more challenging--X-ray imaging approaches, such as X-ray multimodal tomography. Here we present, to our knowledge, the first results of a first successful demonstration experiment in which a monochromatic X-ray beam from a CLS was used for multimodal, i.e., phase-, dark-field, and attenuation-contrast, X-ray tomography. We show results from a fluid phantom with different liquids and a biomedical application example in the form of a multimodal CT scan of a small animal (mouse, ex vivo). The results highlight particularly that quantitative multimodal CT has become feasible with laser-driven CLS, and that the results outperform more conventional approaches. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5340949
- author
- Eggl, Elena
; Schleede, Simone
; Bech, Martin
LU
; Achterhold, Klaus
; Loewen, Roderick
; Ruth, Ronald D
and Pfeiffer, Franz
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Proceedings of the National Academy of Sciences
- volume
- 112
- issue
- 18
- pages
- 5567 - 5572
- publisher
- National Academy of Sciences
- external identifiers
-
- pmid:25902493
- wos:000353953800031
- scopus:84928957996
- pmid:25902493
- ISSN
- 1091-6490
- DOI
- 10.1073/pnas.1500938112
- language
- English
- LU publication?
- yes
- id
- 4e226853-c6f0-4aed-a443-f2b27d2b9b41 (old id 5340949)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25902493?dopt=Abstract
- date added to LUP
- 2016-04-01 10:27:59
- date last changed
- 2025-04-04 14:53:39
@article{4e226853-c6f0-4aed-a443-f2b27d2b9b41,
abstract = {{Between X-ray tubes and large-scale synchrotron sources, a large gap in performance exists with respect to the monochromaticity and brilliance of the X-ray beam. However, due to their size and cost, large-scale synchrotrons are not available for more routine applications in small and medium-sized academic or industrial laboratories. This gap could be closed by laser-driven compact synchrotron light sources (CLS), which use an infrared (IR) laser cavity in combination with a small electron storage ring. Hard X-rays are produced through the process of inverse Compton scattering upon the intersection of the electron bunch with the focused laser beam. The produced X-ray beam is intrinsically monochromatic and highly collimated. This makes a CLS well-suited for applications of more advanced--and more challenging--X-ray imaging approaches, such as X-ray multimodal tomography. Here we present, to our knowledge, the first results of a first successful demonstration experiment in which a monochromatic X-ray beam from a CLS was used for multimodal, i.e., phase-, dark-field, and attenuation-contrast, X-ray tomography. We show results from a fluid phantom with different liquids and a biomedical application example in the form of a multimodal CT scan of a small animal (mouse, ex vivo). The results highlight particularly that quantitative multimodal CT has become feasible with laser-driven CLS, and that the results outperform more conventional approaches.}},
author = {{Eggl, Elena and Schleede, Simone and Bech, Martin and Achterhold, Klaus and Loewen, Roderick and Ruth, Ronald D and Pfeiffer, Franz}},
issn = {{1091-6490}},
language = {{eng}},
number = {{18}},
pages = {{5567--5572}},
publisher = {{National Academy of Sciences}},
series = {{Proceedings of the National Academy of Sciences}},
title = {{X-ray phase-contrast tomography with a compact laser-driven synchrotron source.}},
url = {{https://lup.lub.lu.se/search/files/1868613/8170637.pdf}},
doi = {{10.1073/pnas.1500938112}},
volume = {{112}},
year = {{2015}},
}