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Presence of High-Risk HPV mRNA in Relation to Future High-Grade Lesions among High-Risk HPV DNA Positive Women with Minor Cytological Abnormalities.

Johansson, Hanna K LU ; Bjelkenkrantz, Kaj LU ; Darlin, Lotten LU ; Dillner, Joakim LU and Forslund, Ola LU (2015) In PLoS ONE 10(4).
Abstract
Continuous expression of E6- and E7-oncogenes of high-risk human papillomavirus (HPV) types is necessary for the development and maintenance of the dysplastic phenotype. The aim of the study was to determine the sensitivity and specificity of the APTIMA HPV mRNA assay (Hologic) in predicting future development of high-grade cervical intraepithelial neoplasia (CIN) among high-risk HPV-DNA-positive women with atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous epithelial lesion (LSIL) cytology.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
10
issue
4
publisher
Public Library of Science
external identifiers
  • pmid:25893988
  • wos:000353211700096
  • scopus:84929485283
ISSN
1932-6203
DOI
10.1371/journal.pone.0124460
language
English
LU publication?
yes
id
6cda242e-2841-487f-83af-3e001820c58a (old id 5341218)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25893988?dopt=Abstract
date added to LUP
2015-05-04 17:58:45
date last changed
2017-10-01 04:03:51
@article{6cda242e-2841-487f-83af-3e001820c58a,
  abstract     = {Continuous expression of E6- and E7-oncogenes of high-risk human papillomavirus (HPV) types is necessary for the development and maintenance of the dysplastic phenotype. The aim of the study was to determine the sensitivity and specificity of the APTIMA HPV mRNA assay (Hologic) in predicting future development of high-grade cervical intraepithelial neoplasia (CIN) among high-risk HPV-DNA-positive women with atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous epithelial lesion (LSIL) cytology.},
  articleno    = {e0124460},
  author       = {Johansson, Hanna K and Bjelkenkrantz, Kaj and Darlin, Lotten and Dillner, Joakim and Forslund, Ola},
  issn         = {1932-6203},
  language     = {eng},
  number       = {4},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Presence of High-Risk HPV mRNA in Relation to Future High-Grade Lesions among High-Risk HPV DNA Positive Women with Minor Cytological Abnormalities.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0124460},
  volume       = {10},
  year         = {2015},
}