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Regulation of vascular endothelial growth factor (VEGF) in prostate cancer.

de Brot, Simone; Ntekim, Atara; Cardenas, Ryan; James, Victoria; Allegrucci, Cinzia; Heery, David; Bates, David O; Odum, Niels; Persson, Jenny L LU and Mongan, Nigel P (2015) In Endocrine-Related Cancer 22(3). p.107-123
Abstract
Prostate cancer (PCa) is the most common malignancy affecting men in the western world. While radical prostatectomy and radiation therapy can successfully treat a majority of patients, up to ~30% will experience local recurrence or metastatic disease. Prostate carcinogenesis and progression is typically an androgen dependent process. For this reason, therapies for recurrent PCa target androgen biosynthesis and androgen receptor function. Whilst such androgen deprivation therapies (ADT) are effective initially, the duration of response is typically ≤24 months. While ADT and taxane based chemotherapy have delivered survival benefits, metastatic prostate cancer remains incurable. Therefore it is essential to establish the cellular and... (More)
Prostate cancer (PCa) is the most common malignancy affecting men in the western world. While radical prostatectomy and radiation therapy can successfully treat a majority of patients, up to ~30% will experience local recurrence or metastatic disease. Prostate carcinogenesis and progression is typically an androgen dependent process. For this reason, therapies for recurrent PCa target androgen biosynthesis and androgen receptor function. Whilst such androgen deprivation therapies (ADT) are effective initially, the duration of response is typically ≤24 months. While ADT and taxane based chemotherapy have delivered survival benefits, metastatic prostate cancer remains incurable. Therefore it is essential to establish the cellular and molecular mechanisms which enable localized prostate cancers to invade and disseminate. It has long been accepted that metastases requires angiogenesis. In this review we will examine the essential role for angiogenesis in PCa metastases and in particular we will focus on current understanding of the regulation of vascular endothelial growth factor (VEGF) in localized and metastatic PCa. We will highlight recent advances in understanding the role of VEGF in regulating interaction of cancer cells with tumor-associated immune cells during metastatic process of PCa. We will summarize the established mechanisms of transcriptional and post-transcriptional regulation of VEGF in prostate cancer cells and will outline the molecular insights obtained from pre-clinical animal models of prostate cancer. Finally we will summarize the current state of anti-angiogenesis therapies for PCa and how existing therapies impact on VEGF signalling. . (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Endocrine-Related Cancer
volume
22
issue
3
pages
107 - 123
publisher
Society for Endocrinology
external identifiers
  • pmid:25870249
  • wos:000359003500006
  • scopus:84937040234
ISSN
1479-6821
DOI
10.1530/ERC-15-0123
language
English
LU publication?
yes
id
f8525755-5d7c-4d6c-aa96-d14419e49e0e (old id 5341959)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25870249?dopt=Abstract
date added to LUP
2015-05-05 20:19:10
date last changed
2017-08-27 03:30:58
@article{f8525755-5d7c-4d6c-aa96-d14419e49e0e,
  abstract     = {Prostate cancer (PCa) is the most common malignancy affecting men in the western world. While radical prostatectomy and radiation therapy can successfully treat a majority of patients, up to ~30% will experience local recurrence or metastatic disease. Prostate carcinogenesis and progression is typically an androgen dependent process. For this reason, therapies for recurrent PCa target androgen biosynthesis and androgen receptor function. Whilst such androgen deprivation therapies (ADT) are effective initially, the duration of response is typically ≤24 months. While ADT and taxane based chemotherapy have delivered survival benefits, metastatic prostate cancer remains incurable. Therefore it is essential to establish the cellular and molecular mechanisms which enable localized prostate cancers to invade and disseminate. It has long been accepted that metastases requires angiogenesis. In this review we will examine the essential role for angiogenesis in PCa metastases and in particular we will focus on current understanding of the regulation of vascular endothelial growth factor (VEGF) in localized and metastatic PCa. We will highlight recent advances in understanding the role of VEGF in regulating interaction of cancer cells with tumor-associated immune cells during metastatic process of PCa. We will summarize the established mechanisms of transcriptional and post-transcriptional regulation of VEGF in prostate cancer cells and will outline the molecular insights obtained from pre-clinical animal models of prostate cancer. Finally we will summarize the current state of anti-angiogenesis therapies for PCa and how existing therapies impact on VEGF signalling. .},
  author       = {de Brot, Simone and Ntekim, Atara and Cardenas, Ryan and James, Victoria and Allegrucci, Cinzia and Heery, David and Bates, David O and Odum, Niels and Persson, Jenny L and Mongan, Nigel P},
  issn         = {1479-6821},
  language     = {eng},
  number       = {3},
  pages        = {107--123},
  publisher    = {Society for Endocrinology},
  series       = {Endocrine-Related Cancer},
  title        = {Regulation of vascular endothelial growth factor (VEGF) in prostate cancer.},
  url          = {http://dx.doi.org/10.1530/ERC-15-0123},
  volume       = {22},
  year         = {2015},
}