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Dietary ω-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin.

Fu, Zhongjie; Lofqvist, Chatarina A; Shao, Zhuo; Sun, Ye; Joyal, Jean-Sebastien; Hurst, Christian G; Cui, Ricky Z; Evans, Lucy P; Tian, Katherine and SanGiovanni, John Paul, et al. (2015) In American Journal of Clinical Nutrition 101(4). p.879-888
Abstract
Retinopathy of prematurity (ROP) is a vision-threatening disease in premature infants. Serum adiponectin (APN) concentrations positively correlate with postnatal growth and gestational age, important risk factors for ROP development. Dietary ω-3 (n-3) long-chain polyunsaturated fatty acids (ω-3 LCPUFAs) suppress ROP and oxygen-induced retinopathy (OIR) in a mouse model of human ROP, but the mechanism is not fully understood.
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Contribution to journal
publication status
published
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in
American Journal of Clinical Nutrition
volume
101
issue
4
pages
879 - 888
publisher
American Society for Clinical Nutrition
external identifiers
  • pmid:25833984
  • wos:000352336000023
  • scopus:84929658689
ISSN
1938-3207
DOI
10.3945/ajcn.114.099291
language
English
LU publication?
yes
id
49bd4a8c-386e-4d91-b6e7-8f7bddc174c1 (old id 5360194)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25833984?dopt=Abstract
date added to LUP
2015-05-07 18:03:30
date last changed
2017-10-29 03:13:19
@article{49bd4a8c-386e-4d91-b6e7-8f7bddc174c1,
  abstract     = {Retinopathy of prematurity (ROP) is a vision-threatening disease in premature infants. Serum adiponectin (APN) concentrations positively correlate with postnatal growth and gestational age, important risk factors for ROP development. Dietary ω-3 (n-3) long-chain polyunsaturated fatty acids (ω-3 LCPUFAs) suppress ROP and oxygen-induced retinopathy (OIR) in a mouse model of human ROP, but the mechanism is not fully understood.},
  author       = {Fu, Zhongjie and Lofqvist, Chatarina A and Shao, Zhuo and Sun, Ye and Joyal, Jean-Sebastien and Hurst, Christian G and Cui, Ricky Z and Evans, Lucy P and Tian, Katherine and SanGiovanni, John Paul and Chen, Jing and Ley, David and Pupp, Ingrid and Hellström, Ann and Smith, Lois Eh},
  issn         = {1938-3207},
  language     = {eng},
  number       = {4},
  pages        = {879--888},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {Dietary ω-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin.},
  url          = {http://dx.doi.org/10.3945/ajcn.114.099291},
  volume       = {101},
  year         = {2015},
}