The ratio FEV1/FVC and its association to respiratory symptoms—A Swedish general population study
(2021) In Clinical Physiology and Functional Imaging 41(2). p.181-191- Abstract
Chronic airflow limitation (CAL) can be defined as fixed ratio of forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) < 0.70 after bronchodilation. It is unclear which is the most optimal ratio in relation to respiratory morbidity. The aim was to investigate to what extent different ratios of FEV1/FVC were associated with any respiratory symptom. In a cross-sectional general population study, 15,128 adults (50–64 years of age), 7,120 never-smokers and 8,008 ever-smokers completed a respiratory questionnaire and performed FEV1 and FVC after bronchodilation. We calculated different ratios of FEV1/FVC from 0.40 to 1.0 using 0.70 as reference category. We analysed odds ratios... (More)
Chronic airflow limitation (CAL) can be defined as fixed ratio of forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) < 0.70 after bronchodilation. It is unclear which is the most optimal ratio in relation to respiratory morbidity. The aim was to investigate to what extent different ratios of FEV1/FVC were associated with any respiratory symptom. In a cross-sectional general population study, 15,128 adults (50–64 years of age), 7,120 never-smokers and 8,008 ever-smokers completed a respiratory questionnaire and performed FEV1 and FVC after bronchodilation. We calculated different ratios of FEV1/FVC from 0.40 to 1.0 using 0.70 as reference category. We analysed odds ratios (OR) between different ratios and any respiratory symptom using adjusted multivariable logistic regression. Among all subjects, regardless of smoking habits, the lowest odds for any respiratory symptom was at FEV1/FVC = 0.82, OR 0.48 (95% CI 0.41–0.56). Among never-smokers, the lowest odds for any respiratory symptom was at FEV1/FVC = 0.81, OR 0.53 (95% CI 0.41–0.70). Among ever-smokers, the odds for any respiratory symptom was lowest at FEV1/FVC = 0.81, OR 0.43 (95% CI 0.16–1.19), although the rate of inclining in odds was small in the upper part, that is FEV1/FVC = 0.85 showed similar odds, OR 0.45 (95% CI 0.38–0.55). We concluded that the odds for any respiratory symptoms continuously decreased with higher FEV1/FVC ratios and reached a minimum around 0.80–0.85, with similar results among never-smokers. These results indicate that the optimal threshold associated with respiratory symptoms may be higher than 0.70 and this should be further investigated in prospective longitudinal studies.
(Less)
- author
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- chronic airflow limitation, COPD, cough with phlegm, dyspnoea, GOLD, SCAPIS, wheeze
- in
- Clinical Physiology and Functional Imaging
- volume
- 41
- issue
- 2
- pages
- 181 - 191
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85097904007
- pmid:33284499
- ISSN
- 1475-0961
- DOI
- 10.1111/cpf.12684
- language
- English
- LU publication?
- yes
- id
- 53e790a9-a17e-43e6-a4f1-f7b829247508
- date added to LUP
- 2021-01-11 10:33:49
- date last changed
- 2024-09-19 13:20:15
@article{53e790a9-a17e-43e6-a4f1-f7b829247508, abstract = {{<p>Chronic airflow limitation (CAL) can be defined as fixed ratio of forced expiratory volume in 1 s (FEV<sub>1</sub>)/forced vital capacity (FVC) < 0.70 after bronchodilation. It is unclear which is the most optimal ratio in relation to respiratory morbidity. The aim was to investigate to what extent different ratios of FEV<sub>1</sub>/FVC were associated with any respiratory symptom. In a cross-sectional general population study, 15,128 adults (50–64 years of age), 7,120 never-smokers and 8,008 ever-smokers completed a respiratory questionnaire and performed FEV<sub>1</sub> and FVC after bronchodilation. We calculated different ratios of FEV<sub>1</sub>/FVC from 0.40 to 1.0 using 0.70 as reference category. We analysed odds ratios (OR) between different ratios and any respiratory symptom using adjusted multivariable logistic regression. Among all subjects, regardless of smoking habits, the lowest odds for any respiratory symptom was at FEV<sub>1</sub>/FVC = 0.82, OR 0.48 (95% CI 0.41–0.56). Among never-smokers, the lowest odds for any respiratory symptom was at FEV<sub>1</sub>/FVC = 0.81, OR 0.53 (95% CI 0.41–0.70). Among ever-smokers, the odds for any respiratory symptom was lowest at FEV<sub>1</sub>/FVC = 0.81, OR 0.43 (95% CI 0.16–1.19), although the rate of inclining in odds was small in the upper part, that is FEV<sub>1</sub>/FVC = 0.85 showed similar odds, OR 0.45 (95% CI 0.38–0.55). We concluded that the odds for any respiratory symptoms continuously decreased with higher FEV<sub>1</sub>/FVC ratios and reached a minimum around 0.80–0.85, with similar results among never-smokers. These results indicate that the optimal threshold associated with respiratory symptoms may be higher than 0.70 and this should be further investigated in prospective longitudinal studies.</p>}}, author = {{Torén, Kjell and Schiöler, Linus and Lindberg, Anne and Andersson, Anders and Behndig, Annelie F. and Bergström, Göran and Blomberg, Anders and Caidahl, Kenneth and Engvall, Jan E. and Eriksson, Maria J. and Hamrefors, Viktor and Janson, Christer and Kylhammar, David and Lindberg, Eva and Lindén, Anders and Malinovschi, Andrei and Lennart Persson, Hans and Sandelin, Martin and Eriksson Ström, Jonas and Tanash, Hanan and Vikgren, Jenny and Johan Östgren, Carl and Wollmer, Per and Sköld, C. Magnus}}, issn = {{1475-0961}}, keywords = {{chronic airflow limitation; COPD; cough with phlegm; dyspnoea; GOLD; SCAPIS; wheeze}}, language = {{eng}}, number = {{2}}, pages = {{181--191}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Clinical Physiology and Functional Imaging}}, title = {{The ratio FEV<sub>1</sub>/FVC and its association to respiratory symptoms—A Swedish general population study}}, url = {{http://dx.doi.org/10.1111/cpf.12684}}, doi = {{10.1111/cpf.12684}}, volume = {{41}}, year = {{2021}}, }