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Induced tissue displacement in magnetomotive ultrasound imaging - simulations and experiments

Jansson, Tomas LU ; Evertsson, Maria LU ; Atile, Esayas ; Andersson, Roger LU ; Fredriksson, Sarah ; Persson, Hans W LU ; Svensson, Ingrid LU and Cinthio, Magnus LU orcid (2014) IEEE International Ultrasonics Symposium (IUS), 2014 p.639-642
Abstract
Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move the particles lodged in tissue, and ultrasound is used to detect the resulting tissue movement. In phantom studies we have observed opposite phase motion next to regions containing nanoparticles. We hypothesize that this motion is caused by mechanical coupling from regions where nanoparticles are located. The present study compares experimental data to a numerical simulation with identical geometry as the experimental set-up. The magnetic force acting on particles was modeled as emanating from a coil with a cone shaped iron core, and... (More)
Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move the particles lodged in tissue, and ultrasound is used to detect the resulting tissue movement. In phantom studies we have observed opposite phase motion next to regions containing nanoparticles. We hypothesize that this motion is caused by mechanical coupling from regions where nanoparticles are located. The present study compares experimental data to a numerical simulation with identical geometry as the experimental set-up. The magnetic force acting on particles was modeled as emanating from a coil with a cone shaped iron core, and applied as a body load in nanoparticle-laden regions. The simulation showed opposed motion in-between nanoparticle-laden phantom inserts, in a manner similar to the experimental situation. There is a slight mismatch in the extent of vertical movement, which we interpret as a result of the modeled slip condition tangentially to the surface, which in reality presumably is a combination of slip and stick due to friction. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
molecular imaging, contrast agents, superparamagnetic, iron oxide, nanoparticles
host publication
2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)
pages
639 - 642
publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
conference name
IEEE International Ultrasonics Symposium (IUS), 2014
conference location
Chicago, IL, United States
conference dates
2014-09-03 - 2014-09-06
external identifiers
  • wos:000352792500157
  • scopus:84910026944
DOI
10.1109/ULTSYM.2014.0157
language
English
LU publication?
yes
id
f3966dc7-5933-4a60-8cec-11777dac0be5 (old id 5401212)
date added to LUP
2016-04-04 10:40:02
date last changed
2024-10-13 09:09:15
@inproceedings{f3966dc7-5933-4a60-8cec-11777dac0be5,
  abstract     = {{Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move the particles lodged in tissue, and ultrasound is used to detect the resulting tissue movement. In phantom studies we have observed opposite phase motion next to regions containing nanoparticles. We hypothesize that this motion is caused by mechanical coupling from regions where nanoparticles are located. The present study compares experimental data to a numerical simulation with identical geometry as the experimental set-up. The magnetic force acting on particles was modeled as emanating from a coil with a cone shaped iron core, and applied as a body load in nanoparticle-laden regions. The simulation showed opposed motion in-between nanoparticle-laden phantom inserts, in a manner similar to the experimental situation. There is a slight mismatch in the extent of vertical movement, which we interpret as a result of the modeled slip condition tangentially to the surface, which in reality presumably is a combination of slip and stick due to friction.}},
  author       = {{Jansson, Tomas and Evertsson, Maria and Atile, Esayas and Andersson, Roger and Fredriksson, Sarah and Persson, Hans W and Svensson, Ingrid and Cinthio, Magnus}},
  booktitle    = {{2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS)}},
  keywords     = {{molecular imaging; contrast agents; superparamagnetic; iron oxide; nanoparticles}},
  language     = {{eng}},
  pages        = {{639--642}},
  publisher    = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
  title        = {{Induced tissue displacement in magnetomotive ultrasound imaging - simulations and experiments}},
  url          = {{http://dx.doi.org/10.1109/ULTSYM.2014.0157}},
  doi          = {{10.1109/ULTSYM.2014.0157}},
  year         = {{2014}},
}