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Hypothermia Affects Translocation of Numerous Cytoplasmic Proteins Following Global Cerebral Ischemia.

Teilum, Maria LU ; Krogh, Morten LU ; Wieloch, Tadeusz LU and Mattiasson, Gustav LU (2007) In Journal of Proteome Research 6(7). p.2822-2832
Abstract
Using a decapitation ischemia model, we studied translocation of proteins to and from the cytosol in normothermic (NT) and hypothermic (HT) rat brains. 2D gel analysis identified 74 proteins whose cytosolic level changed significantly after 15 min of ischemia. HT preserved the cytosolic levels of several glycolytic enzymes, as well as many plasticity related proteins, otherwise decreased following NT ischemia. The levels of redox-related proteins was lower in HT than in NT. Our results indicate that translocation of proteins to and from the cytosol is an important issue during ischemia.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cytoskeleton, 2D gel cortex, glycolysis, LC-MS/MS, MALDI, plasticity, redox-sensitive
in
Journal of Proteome Research
volume
6
issue
7
pages
2822 - 2832
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000247792300041
  • scopus:34547161332
ISSN
1535-3893
DOI
10.1021/pr070057l
language
English
LU publication?
yes
id
2505caff-bb6f-4d79-b978-10996a667843 (old id 540124)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17536849&dopt=Abstract
date added to LUP
2016-04-01 11:47:59
date last changed
2024-01-07 20:59:09
@article{2505caff-bb6f-4d79-b978-10996a667843,
  abstract     = {{Using a decapitation ischemia model, we studied translocation of proteins to and from the cytosol in normothermic (NT) and hypothermic (HT) rat brains. 2D gel analysis identified 74 proteins whose cytosolic level changed significantly after 15 min of ischemia. HT preserved the cytosolic levels of several glycolytic enzymes, as well as many plasticity related proteins, otherwise decreased following NT ischemia. The levels of redox-related proteins was lower in HT than in NT. Our results indicate that translocation of proteins to and from the cytosol is an important issue during ischemia.}},
  author       = {{Teilum, Maria and Krogh, Morten and Wieloch, Tadeusz and Mattiasson, Gustav}},
  issn         = {{1535-3893}},
  keywords     = {{cytoskeleton; 2D gel cortex; glycolysis; LC-MS/MS; MALDI; plasticity; redox-sensitive}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{2822--2832}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Journal of Proteome Research}},
  title        = {{Hypothermia Affects Translocation of Numerous Cytoplasmic Proteins Following Global Cerebral Ischemia.}},
  url          = {{http://dx.doi.org/10.1021/pr070057l}},
  doi          = {{10.1021/pr070057l}},
  volume       = {{6}},
  year         = {{2007}},
}