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Modelling of the oxygen level response to feed rate perturbations in an industrial scale fermentation process

Johnsson, Ola LU ; Andersson, Jonas; Lidén, Gunnar LU ; Johnsson, Charlotta LU and Hägglund, Tore LU (2015) In Process Biochemistry 50(4). p.507-516
Abstract
A study of the feasibility of perturbation-based control methods in industrial fed-batch fermentations based on experiments in industrial production scale bioreactors (>100 m(3)) is presented, as well as modelling of the relation between substrate feed rate and dissolved oxygen level in such a process. Several different types of perturbation-based control methods have been suggested for control of this type of process but it has been reported that perturbations in the feed rate may cause decreased productivity in fermentations. The results of this study show that perturbations in the feed rate of production scale fermentations can achieve significant dissolved oxygen level responses without decreased productivity. A model based on data... (More)
A study of the feasibility of perturbation-based control methods in industrial fed-batch fermentations based on experiments in industrial production scale bioreactors (>100 m(3)) is presented, as well as modelling of the relation between substrate feed rate and dissolved oxygen level in such a process. Several different types of perturbation-based control methods have been suggested for control of this type of process but it has been reported that perturbations in the feed rate may cause decreased productivity in fermentations. The results of this study show that perturbations in the feed rate of production scale fermentations can achieve significant dissolved oxygen level responses without decreased productivity. A model based on data for dissolved oxygen responses and a simulation using a simple observer are given, showing that it is possible to model industrial mixing dynamics in a simple way and that this can be used for perturbation-based on-line estimation of the metabolic state of the system in regard to overflow metabolism. A frequency region where the model can be used has been identified, indicating which frequencies would be suitable for perturbation-based control in industrial fermentations. (C) 2015 Elsevier Ltd. All rights reserved. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Process modelling, Process control, Perturbation-based control, Industrial fermentation, Bacillus licheniformis
in
Process Biochemistry
volume
50
issue
4
pages
507 - 516
publisher
Elsevier
external identifiers
  • wos:000353073100003
  • scopus:84925588883
ISSN
1873-3298
DOI
10.1016/j.procbio.2015.01.009
language
English
LU publication?
yes
id
d728b2aa-2836-44e2-947c-d80027b7e741 (old id 5401717)
date added to LUP
2015-05-19 12:41:31
date last changed
2017-10-22 03:01:38
@article{d728b2aa-2836-44e2-947c-d80027b7e741,
  abstract     = {A study of the feasibility of perturbation-based control methods in industrial fed-batch fermentations based on experiments in industrial production scale bioreactors (>100 m(3)) is presented, as well as modelling of the relation between substrate feed rate and dissolved oxygen level in such a process. Several different types of perturbation-based control methods have been suggested for control of this type of process but it has been reported that perturbations in the feed rate may cause decreased productivity in fermentations. The results of this study show that perturbations in the feed rate of production scale fermentations can achieve significant dissolved oxygen level responses without decreased productivity. A model based on data for dissolved oxygen responses and a simulation using a simple observer are given, showing that it is possible to model industrial mixing dynamics in a simple way and that this can be used for perturbation-based on-line estimation of the metabolic state of the system in regard to overflow metabolism. A frequency region where the model can be used has been identified, indicating which frequencies would be suitable for perturbation-based control in industrial fermentations. (C) 2015 Elsevier Ltd. All rights reserved.},
  author       = {Johnsson, Ola and Andersson, Jonas and Lidén, Gunnar and Johnsson, Charlotta and Hägglund, Tore},
  issn         = {1873-3298},
  keyword      = {Process modelling,Process control,Perturbation-based control,Industrial fermentation,Bacillus licheniformis},
  language     = {eng},
  number       = {4},
  pages        = {507--516},
  publisher    = {Elsevier},
  series       = {Process Biochemistry},
  title        = {Modelling of the oxygen level response to feed rate perturbations in an industrial scale fermentation process},
  url          = {http://dx.doi.org/10.1016/j.procbio.2015.01.009},
  volume       = {50},
  year         = {2015},
}