Advanced

Importance of Thrombocytes for the Hypertrophy Response after Portal Vein Embolization

Sturesson, Christian LU ; Hoekstra, Lisette; Andersson, Roland LU and van Gulik, Thomas M. (2015) In Hepato-Gastroenterology 62(137). p.98-101
Abstract
Background/Aims: Thrombocytes have proved to be important for liver regeneration after liver resection in the experimental setting. The aim of our study is to examine the effects of thrombocytes on liver hypertrophy after portal vein embolization (PVE). Methodology: This retrospective cohort study comprised 75 patients with liver metastases from colorectal cancer subjected to PVE in preparation for major liver resection. Patients were divided into 2 groups depending On if chemotherapy was given within 6 weeks before PVE or not. Results: The chemotherapy group Showed-lower levels of thrombocytes (p=0.003) and lower degree Of hypertrophy (p=0.030) as Compared to the group without chemotherapy. No correlation within groups between level of... (More)
Background/Aims: Thrombocytes have proved to be important for liver regeneration after liver resection in the experimental setting. The aim of our study is to examine the effects of thrombocytes on liver hypertrophy after portal vein embolization (PVE). Methodology: This retrospective cohort study comprised 75 patients with liver metastases from colorectal cancer subjected to PVE in preparation for major liver resection. Patients were divided into 2 groups depending On if chemotherapy was given within 6 weeks before PVE or not. Results: The chemotherapy group Showed-lower levels of thrombocytes (p=0.003) and lower degree Of hypertrophy (p=0.030) as Compared to the group without chemotherapy. No correlation within groups between level of thrombocytes and degree of hypertrophy was found. However, in the chemotherapy group, a positive linear correlation between the degree of hypertrophy and the difference in thrombocytes between the time points of PVE and 2 months preceding PVE was found (p=0.0006). Discussion: Preprocedural chemotherapy results in decreased hypertrophy of the liver after PVE and lower levels of thrombocytes at the time for PVE. The absolute number of thrombocytes does not influence liver regeneration after PVE. For patients receiving preprocedural chemotherapy, PVE performed at a time when thrombocytes are decreasing is associated with a reduced regeneration. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Platelets, Colorectal liver metastases, Chemotherapy
in
Hepato-Gastroenterology
volume
62
issue
137
pages
98 - 101
publisher
Georg Thieme Verlag
external identifiers
  • wos:000352115700020
  • scopus:84928560409
ISSN
0172-6390
DOI
10.5754/hge12644
language
English
LU publication?
yes
id
c002bf15-f60b-4176-9583-b6eb7467489a (old id 5403182)
date added to LUP
2015-06-01 09:24:54
date last changed
2017-02-26 03:50:55
@article{c002bf15-f60b-4176-9583-b6eb7467489a,
  abstract     = {Background/Aims: Thrombocytes have proved to be important for liver regeneration after liver resection in the experimental setting. The aim of our study is to examine the effects of thrombocytes on liver hypertrophy after portal vein embolization (PVE). Methodology: This retrospective cohort study comprised 75 patients with liver metastases from colorectal cancer subjected to PVE in preparation for major liver resection. Patients were divided into 2 groups depending On if chemotherapy was given within 6 weeks before PVE or not. Results: The chemotherapy group Showed-lower levels of thrombocytes (p=0.003) and lower degree Of hypertrophy (p=0.030) as Compared to the group without chemotherapy. No correlation within groups between level of thrombocytes and degree of hypertrophy was found. However, in the chemotherapy group, a positive linear correlation between the degree of hypertrophy and the difference in thrombocytes between the time points of PVE and 2 months preceding PVE was found (p=0.0006). Discussion: Preprocedural chemotherapy results in decreased hypertrophy of the liver after PVE and lower levels of thrombocytes at the time for PVE. The absolute number of thrombocytes does not influence liver regeneration after PVE. For patients receiving preprocedural chemotherapy, PVE performed at a time when thrombocytes are decreasing is associated with a reduced regeneration.},
  author       = {Sturesson, Christian and Hoekstra, Lisette and Andersson, Roland and van Gulik, Thomas M.},
  issn         = {0172-6390},
  keyword      = {Platelets,Colorectal liver metastases,Chemotherapy},
  language     = {eng},
  number       = {137},
  pages        = {98--101},
  publisher    = {Georg Thieme Verlag},
  series       = {Hepato-Gastroenterology},
  title        = {Importance of Thrombocytes for the Hypertrophy Response after Portal Vein Embolization},
  url          = {http://dx.doi.org/10.5754/hge12644},
  volume       = {62},
  year         = {2015},
}