Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals
(2021) In Nature Medicine 27(2). p.321-332- Abstract
The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Personalised Responses to Dietary Composition Trial (PREDICT 1) study, whose detailed long-term diet information, as well as hundreds of fasting and same-meal postprandial cardiometabolic blood marker measurements were available. We found many significant associations between microbes and specific nutrients, foods, food groups and general dietary indices, which were driven especially by the presence and diversity of healthy and plant-based foods. Microbial biomarkers of obesity were reproducible... (More)
The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Personalised Responses to Dietary Composition Trial (PREDICT 1) study, whose detailed long-term diet information, as well as hundreds of fasting and same-meal postprandial cardiometabolic blood marker measurements were available. We found many significant associations between microbes and specific nutrients, foods, food groups and general dietary indices, which were driven especially by the presence and diversity of healthy and plant-based foods. Microbial biomarkers of obesity were reproducible across external publicly available cohorts and in agreement with circulating blood metabolites that are indicators of cardiovascular disease risk. While some microbes, such as Prevotella copri and Blastocystis spp., were indicators of favorable postprandial glucose metabolism, overall microbiome composition was predictive for a large panel of cardiometabolic blood markers including fasting and postprandial glycemic, lipemic and inflammatory indices. The panel of intestinal species associated with healthy dietary habits overlapped with those associated with favorable cardiometabolic and postprandial markers, indicating that our large-scale resource can potentially stratify the gut microbiome into generalizable health levels in individuals without clinically manifest disease.
(Less)
- author
- organization
- publishing date
- 2021-01-11
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Medicine
- volume
- 27
- issue
- 2
- pages
- 321 - 332
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85100135155
- pmid:33432175
- ISSN
- 1078-8956
- DOI
- 10.1038/s41591-020-01183-8
- language
- English
- LU publication?
- yes
- id
- 5409314a-6333-4b46-bd89-04c4958c9e95
- date added to LUP
- 2021-02-15 10:50:43
- date last changed
- 2024-06-14 09:48:20
@article{5409314a-6333-4b46-bd89-04c4958c9e95,
abstract = {{<p>The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Personalised Responses to Dietary Composition Trial (PREDICT 1) study, whose detailed long-term diet information, as well as hundreds of fasting and same-meal postprandial cardiometabolic blood marker measurements were available. We found many significant associations between microbes and specific nutrients, foods, food groups and general dietary indices, which were driven especially by the presence and diversity of healthy and plant-based foods. Microbial biomarkers of obesity were reproducible across external publicly available cohorts and in agreement with circulating blood metabolites that are indicators of cardiovascular disease risk. While some microbes, such as Prevotella copri and Blastocystis spp., were indicators of favorable postprandial glucose metabolism, overall microbiome composition was predictive for a large panel of cardiometabolic blood markers including fasting and postprandial glycemic, lipemic and inflammatory indices. The panel of intestinal species associated with healthy dietary habits overlapped with those associated with favorable cardiometabolic and postprandial markers, indicating that our large-scale resource can potentially stratify the gut microbiome into generalizable health levels in individuals without clinically manifest disease.</p>}},
author = {{Asnicar, Francesco and Berry, Sarah E. and Valdes, Ana M. and Nguyen, Long H. and Piccinno, Gianmarco and Drew, David A. and Leeming, Emily and Gibson, Rachel and Le Roy, Caroline and Khatib, Haya Al and Francis, Lucy and Mazidi, Mohsen and Mompeo, Olatz and Valles-Colomer, Mireia and Tett, Adrian and Beghini, Francesco and Dubois, Léonard and Bazzani, Davide and Thomas, Andrew Maltez and Mirzayi, Chloe and Khleborodova, Asya and Oh, Sehyun and Hine, Rachel and Bonnett, Christopher and Capdevila, Joan and Danzanvilliers, Serge and Giordano, Francesca and Geistlinger, Ludwig and Waldron, Levi and Davies, Richard and Hadjigeorgiou, George and Wolf, Jonathan and Ordovás, José M. and Gardner, Christopher and Franks, Paul W. and Chan, Andrew T. and Huttenhower, Curtis and Spector, Tim D. and Segata, Nicola}},
issn = {{1078-8956}},
language = {{eng}},
month = {{01}},
number = {{2}},
pages = {{321--332}},
publisher = {{Nature Publishing Group}},
series = {{Nature Medicine}},
title = {{Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals}},
url = {{http://dx.doi.org/10.1038/s41591-020-01183-8}},
doi = {{10.1038/s41591-020-01183-8}},
volume = {{27}},
year = {{2021}},
}