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Personalised nutrition : status and perspectives

Joost, Hans-Georg; Gibney, Michael J.; Cashman, Kevin D.; Görman, Ulf LU ; Hesketh, John E.; Mueller, Michael; van Ommen, Ben; Williams, Christine M. and Mathers, John C. (2007) In British Journal of Nutrition 98(01). p.26-31
Abstract
Personalised, genotype-based nutrition is a concept that links genotyping with specific nutritional advice in order to improve the prevention of nutrition-associated, chronic diseases. This review describes the current scientific basis of the concept and discusses its problems. There is convincing evidence that variant genes may indeed determine the biological response to nutrients. The effects of single-gene variants on risk or risk factor levels of a complex disease are, however, usually small and sometimes inconsistent. Thus, information on the effects of combinations of relevant gene variants appears to be required in order to improve the predictive precision of the genetic information. Furthermore, very few associations between... (More)
Personalised, genotype-based nutrition is a concept that links genotyping with specific nutritional advice in order to improve the prevention of nutrition-associated, chronic diseases. This review describes the current scientific basis of the concept and discusses its problems. There is convincing evidence that variant genes may indeed determine the biological response to nutrients. The effects of single-gene variants on risk or risk factor levels of a complex disease are, however, usually small and sometimes inconsistent. Thus, information on the effects of combinations of relevant gene variants appears to be required in order to improve the predictive precision of the genetic information. Furthermore, very few associations between genotype and response have been tested for causality in human intervention studies, and little is known about potential adverse effects of a genotype-derived intervention. These issues need to be addressed before genotyping can become an acceptable method to guide nutritional recommendations. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
disease risk, genotype, nutrigenetics, nutritional recommendations, nutrigenomics
in
British Journal of Nutrition
volume
98
issue
01
pages
26 - 31
publisher
Cambridge University Press
external identifiers
  • wos:000248305100004
  • scopus:34547989732
ISSN
1475-2662
DOI
10.1017/S0007114507685195
language
English
LU publication?
yes
id
bfa18647-ae26-4834-80d4-5a710f684a5e (old id 541239)
date added to LUP
2007-11-13 12:05:06
date last changed
2017-10-08 03:31:41
@article{bfa18647-ae26-4834-80d4-5a710f684a5e,
  abstract     = {Personalised, genotype-based nutrition is a concept that links genotyping with specific nutritional advice in order to improve the prevention of nutrition-associated, chronic diseases. This review describes the current scientific basis of the concept and discusses its problems. There is convincing evidence that variant genes may indeed determine the biological response to nutrients. The effects of single-gene variants on risk or risk factor levels of a complex disease are, however, usually small and sometimes inconsistent. Thus, information on the effects of combinations of relevant gene variants appears to be required in order to improve the predictive precision of the genetic information. Furthermore, very few associations between genotype and response have been tested for causality in human intervention studies, and little is known about potential adverse effects of a genotype-derived intervention. These issues need to be addressed before genotyping can become an acceptable method to guide nutritional recommendations.},
  author       = {Joost, Hans-Georg and Gibney, Michael J. and Cashman, Kevin D. and Görman, Ulf and Hesketh, John E. and Mueller, Michael and van Ommen, Ben and Williams, Christine M. and Mathers, John C.},
  issn         = {1475-2662},
  keyword      = {disease risk,genotype,nutrigenetics,nutritional recommendations,nutrigenomics},
  language     = {eng},
  number       = {01},
  pages        = {26--31},
  publisher    = {Cambridge University Press},
  series       = {British Journal of Nutrition},
  title        = {Personalised nutrition : status and perspectives},
  url          = {http://dx.doi.org/10.1017/S0007114507685195},
  volume       = {98},
  year         = {2007},
}