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Linear decline of corrected platelet count increment within 24 hours after platelet transfusion in haematological patients : a prospective observational study

Benediktsson, Sigurdur LU ; Lazarevic, Vladimir LU ; Nilsson, Lars LU ; Kjeldsen-Kragh, Jens LU ; Schött, Ulf LU and Kander, Thomas LU (2017) In European Journal of Haematology1987-01-01+01:00 p.559-568
Abstract

OBJECTIVES: The aim of the present study was to prospectively explore the detailed longitudinal development of platelet increments in patients with chemotherapy-induced bone marrow aplasia during the first 24 hours after platelet transfusion.

METHODS: Patients admitted to the Haematology department during 7 months and fulfilled inclusion criteria were divided into 4 groups: Group 1, patients with acute leukaemia; Group 2, patients after autologous stem cell transplantation (SCT); Group 3, patients after allogeneic SCT; Group 4, patients given platelet transfusion prior to intervention. We used frequent blood sampling within 24 hours after platelet transfusion to investigate the kinetics of platelet counts following... (More)

OBJECTIVES: The aim of the present study was to prospectively explore the detailed longitudinal development of platelet increments in patients with chemotherapy-induced bone marrow aplasia during the first 24 hours after platelet transfusion.

METHODS: Patients admitted to the Haematology department during 7 months and fulfilled inclusion criteria were divided into 4 groups: Group 1, patients with acute leukaemia; Group 2, patients after autologous stem cell transplantation (SCT); Group 3, patients after allogeneic SCT; Group 4, patients given platelet transfusion prior to intervention. We used frequent blood sampling within 24 hours after platelet transfusion to investigate the kinetics of platelet counts following transfusion.

RESULTS AND CONCLUSIONS: 54 platelet transfusion occasions in patients with chemotherapy-induced bone marrow aplasia were included. The decrease of corrected count increment (CCI) 1-24 hours after platelet transfusions in all groups could be described as linear functions. For patients in the aggregated Groups 1-3, the decline was 2.0%± 0.6% (mean± standard deviation) per hour. For patients in Group 4, the decline of CCI was 2.8%± 1.2% per hour. We found no differences between the groups, either in the rate of platelet elimination from the bloodstream or in the mean CCI, in the first 24 hours post-transfusion. This article is protected by copyright. All rights reserved.

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organization
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type
Contribution to journal
publication status
published
subject
in
European Journal of Haematology1987-01-01+01:00
pages
559 - 568
publisher
Wiley-Blackwell
external identifiers
  • scopus:85031430925
  • wos:000416145400013
ISSN
1600-0609
DOI
10.1111/ejh.12974
language
English
LU publication?
yes
id
54377b31-421b-4e58-87e8-1b2d2bee4d16
date added to LUP
2017-10-16 14:14:05
date last changed
2018-05-29 09:49:43
@article{54377b31-421b-4e58-87e8-1b2d2bee4d16,
  abstract     = {<p>OBJECTIVES: The aim of the present study was to prospectively explore the detailed longitudinal development of platelet increments in patients with chemotherapy-induced bone marrow aplasia during the first 24 hours after platelet transfusion.</p><p>METHODS: Patients admitted to the Haematology department during 7 months and fulfilled inclusion criteria were divided into 4 groups: Group 1, patients with acute leukaemia; Group 2, patients after autologous stem cell transplantation (SCT); Group 3, patients after allogeneic SCT; Group 4, patients given platelet transfusion prior to intervention. We used frequent blood sampling within 24 hours after platelet transfusion to investigate the kinetics of platelet counts following transfusion.</p><p>RESULTS AND CONCLUSIONS: 54 platelet transfusion occasions in patients with chemotherapy-induced bone marrow aplasia were included. The decrease of corrected count increment (CCI) 1-24 hours after platelet transfusions in all groups could be described as linear functions. For patients in the aggregated Groups 1-3, the decline was 2.0%± 0.6% (mean± standard deviation) per hour. For patients in Group 4, the decline of CCI was 2.8%± 1.2% per hour. We found no differences between the groups, either in the rate of platelet elimination from the bloodstream or in the mean CCI, in the first 24 hours post-transfusion. This article is protected by copyright. All rights reserved.</p>},
  author       = {Benediktsson, Sigurdur and Lazarevic, Vladimir and Nilsson, Lars and Kjeldsen-Kragh, Jens and Schött, Ulf and Kander, Thomas},
  issn         = {1600-0609},
  language     = {eng},
  pages        = {559--568},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Haematology1987-01-01+01:00},
  title        = {Linear decline of corrected platelet count increment within 24 hours after platelet transfusion in haematological patients : a prospective observational study},
  url          = {http://dx.doi.org/10.1111/ejh.12974},
  year         = {2017},
}